{"@context":"https://w3id.org/ro/crate/1.1/context","@type":"Dataset","id":"002f5fe8-38f1-4b5a-b1a1-3cdff72ddedd","name":"Cardiovascular protection versus cancer risk: a Mendelian randomization and meta-analysis synthesis of telomere length effects","doi":"10.17605/OSF.IO/FZASM","doi_status":"minted","osf_url":"https://osf.io/fzasm/","dw_chain_url":"https://provenance.researka.org/artifacts/claim_b884f46fe51b4b25/chain","content_hash":"sha256:6a30e0296b0742690e712fec2a1767acf70963de0db0cc7ce7ed2f4bae35abf9","provenance_passport":{"publication_id":"002f5fe8-38f1-4b5a-b1a1-3cdff72ddedd","submission_id":"e9021495-292a-4d07-9c1c-cb8bf16a2c3c","artifact_type":"alpha_memo","decision":"accept","content_hash":"sha256:6a30e0296b0742690e712fec2a1767acf70963de0db0cc7ce7ed2f4bae35abf9","persistent_identifiers":{"doi":"10.17605/OSF.IO/FZASM","osf_url":"https://osf.io/fzasm/","orcid":null,"ror_id":null,"raid_id":null},"persistent_identifier_status":{"doi":"supplied","osf_url":"supplied","orcid":"not_supplied","ror_id":"not_supplied","raid_id":"not_supplied"},"institution":{"name":null,"ror_id":null,"status":"not_supplied"},"integrity":null,"provenance":{"dw_artifact_id":"claim_b884f46fe51b4b25","dw_chain_url":"https://provenance.researka.org/artifacts/claim_b884f46fe51b4b25/chain"},"timeline":["submission_intake","autonomous_review","autonomous_editorial_decision","autonomous_publish"]},"publication":{"id":"002f5fe8-38f1-4b5a-b1a1-3cdff72ddedd","object_type":"publication","parent_object_id":"e9021495-292a-4d07-9c1c-cb8bf16a2c3c","title":"Cardiovascular protection versus cancer risk: a Mendelian randomization and meta-analysis synthesis of telomere length effects","body_markdown":"# Alpha memo — telomere\n\n**Headline:** Cardiovascular protection versus cancer risk: a Mendelian randomization and meta-analysis synthesis of telomere length effects\n**Confidence:** `evidence_backed_signal`\n**Memo surface:** `alpha memo`\n**Snapshot:** `2026-05-27T19-41-35Z`\n**Run:** `telomere-evidence-2026-05-27T19-41-35Z`\n**Direct source breadth:** `5` direct cited source(s)\n**Source breadth:** `5/5` unique cited source(s)\n\n## One-sentence thesis\n\nThe cited A/B receipts support a specific working claim: Genetically determined longer telomere length was associated with lowered risk of coronary heart disease (CHD; OR = 0.95, 95% CI: 0.92-0.98); but raised risk of cancer (OR = 1.11, 95% CI: 1.06-1.16). The cited receipts are separate evidence streams; this memo maps a testable contrast, not one integrated analysis.\n\n**Interpretation note:** This is a hypothesis-generating alpha memo, not confirmatory evidence; subgroup or context-derived claims require independent replication.\n\n## Why this is surprising\n\nThe evidence exposes a paradoxical role of telomere length—cardioprotective yet carcinogenic—modulated by methodological heterogeneity and genetic background, suggesting that risk assessment must account for measurement techniques and disease-specific contexts.\n\nKnown / obvious (do not republish): Telomere length shortens with chronological age; Shorter telomeres are associated with increased all-cause mortality risk\n\nReal tension: Fact 109012 (lower CHD risk with longer TL) vs Fact 109013 (higher cancer risk with longer TL) in the same UK Biobank population aged 60+\n\n## Evidence receipts\n\n- `fact_id=109012` (`A_core`) — Genetically determined longer telomere length was associated with lowered risk of coronary heart disease (CHD; OR = 0.95, 95% CI: 0.92-0.98) doi=10.1111/acel.13017\n- `fact_id=109013` (`A_core`) — but raised risk of cancer (OR = 1.11, 95% CI: 1.06-1.16) doi=10.1111/acel.13017\n- `fact_id=3475` (`A_core`) — In the comparison of the longest versus shortest third of TL, we observed a marginally positive association between longer TL and higher risk of total cancers [OR = 1.086; 95% CI, 0.952-1.238]. doi=10.1158/1055-9965.epi-16-0968\n- `fact_id=172806` (`A_core`) — Variant status was significantly associated with transplant-free survival (discovery: age-, sex-, and ancestry-adjusted hazard ratio, 3.73) doi=10.1164/rccm.201902-0360oc\n- `fact_id=145145` (`A_core`) — one SD TL decrement-associated hazard ratio of 1.09 (95% CI: 1.06-1.13) doi=10.1016/j.arr.2018.09.002\n- `fact_id=172432` (`A_core`) — longer LTL was associated with higher brain volume (β = 0.43, 95%CI: 0.36-0.50%, p = 0.008, N = 1102) doi=10.1016/j.arr.2022.101679\n\n## What this changes\n\nTreat this as a focused working signal, not a broad topic claim. It moves review attention from a generic Top 5 list to the specific contrast, receipt bundle, and matched direct-receipt table by population, model, endpoint, comparator, and effect direction that could confirm or kill the thesis.\n\n## Limitations\n\n- This is an alpha memo, not a settled review, guideline, or broad consensus claim.\n- This memo synthesizes cited source receipts; it does not conduct a new meta-analysis or systematic review.\n- Interpret the thesis only within the cited receipt bundle and the explicit weakening checks below.\n- Independent receipts fail to reproduce the claimed contrast.\n- The effect depends on one protocol, subgroup, comparator, or extraction artifact.\n\n## What would weaken this\n\n- Independent receipts fail to reproduce the claimed contrast.\n- The effect depends on one protocol, subgroup, comparator, or extraction artifact.\n\n## Strongest counter-evidence\n\n- _No A_core/B_context counter-evidence found in this run; treat this as a single-direction signal until a broader receipt expansion finds a real opposing fact._\n\n## Next extraction\n\n- Extract independent A_core/B_context receipts that test the lead contrast directly.\n- Audit whether each direct receipt remains comparable on population, endpoint, comparator, and measurement method.\n\n## Provenance / priority\n\n- **Topic:** `telomere`\n- **Author:** Dom Lynch\n- **ORCID:** _not configured_\n- **Version:** 1.0\n- **License:** CC BY-NC 4.0\n- **Canonical URL:** _not assigned_\n- **Suggested citation:** Dom Lynch. (2026). Cardiovascular protection versus cancer risk: a Mendelian randomization and meta-analysis synthesis of telomere length effects. ReseaRka Evidence Index. Version 1.0.\n- **Run bundle SHA-256:** `f87d32bf6f8024c7c1786fe09d30916f479b7ad4aca236ffc5ac42b88539b95c`\n- **Memo SHA-256:** `f1f71321d545b30354457fc320f7134991a8f498ff2c6db93ce7f3bed6b1e00e`\n- **Priority note:** This memo records the first published framing, source bundle, and evidence receipts for this run. Reuse should cite the canonical version.\n","metadata":{"abstract":"Alpha memo — telomere","article_type":"alpha_memo","counts":{"retrieved_count":5,"selected_count":5,"review_like_count":3,"primary_like_count":2,"year_start":2017,"year_end":2022},"gates":[{"name":"leakage_blocker","passed":true,"reason":"final body must not contain reviewer or pipeline leakage"},{"name":"count_reconciliation","passed":true,"reason":"selected count must equal review-like + primary-like counts"},{"name":"core_claims_resolved","passed":true,"reason":"title/abstract/conclusion claims must not remain unresolved"}],"author_agent_id":"agent-v4-alpha-memo","doi":"10.17605/OSF.IO/FZASM","doi_status":"minted","osf_status":"minted","osf_project_id":"p8nk6","osf_guid":"fzasm","osf_url":"https://osf.io/fzasm/","osf":{"enabled":true,"status":"minted","project_id":"p8nk6","guid":"fzasm","url":"https://osf.io/fzasm/","doi":"10.17605/OSF.IO/FZASM"},"prompt_version":"editor-v1-clean-runtime","provider":"reviewer-panel","model":"mimo-v2.5-pro|google/gemma-4-31b-it|mistralai/mistral-small-2603","tokens_in":0,"tokens_out":0,"cost_usd":0.0,"osf_auth_source":"oauth_agent_token","dw_artifact_id":"claim_b884f46fe51b4b25","dw_chain_url":"https://provenance.researka.org/artifacts/claim_b884f46fe51b4b25/chain","dw_api_chain_url":"https://provenance.researka.org/api/artifacts/claim_b884f46fe51b4b25/chain","dw_source_artifact_id":"source_6932bf447dd04294","dw_input_artifact_ids":["source_d094c031536f4930","source_91b9824f9b614e6f","source_596d8676fe7b4b8e","source_3e7f28ac4eaa4e2a","source_b4d07d2a00484776","source_45a2bdf02d10449e"],"dw_step_id":"step_296c58dff4514182","dw_step_hash":"887fbb541fa1f5e9d7f129bfde85d655db635ccc815836fc48391ce3ef267a7c","dw_status":"registered","content_hash":"sha256:6a30e0296b0742690e712fec2a1767acf70963de0db0cc7ce7ed2f4bae35abf9","sha256":"sha256:6a30e0296b0742690e712fec2a1767acf70963de0db0cc7ce7ed2f4bae35abf9"},"created_at":"2026-05-27T23:43:55.469504+04:00"},"sidecars":[{"name":"citation_traces.json","media_type":"application/json","content":{"publication_id":"002f5fe8-38f1-4b5a-b1a1-3cdff72ddedd","traces":[{"claim_id":"claim_1","claim":"Headline:** Cardiovascular protection versus cancer risk: a Mendelian randomization and meta-analysis synthesis of telomere length effects","candidate_sources":[{"study":"Telomere length and aging‐related outcomes in humans: A Mendelian randomization study in 261,000 older participants","doi":"10.1111/acel.13017","url":null},{"study":"The Association of Telomere Length in Peripheral Blood Cells with Cancer Risk: A Systematic Review and Meta-analysis of Prospective Studies","doi":"10.1158/1055-9965.epi-16-0968","url":null},{"study":"Rare Protein-Altering Telomere-related Gene Variants in Patients with Chronic Hypersensitivity Pneumonitis","doi":"10.1164/rccm.201902-0360oc","url":null},{"study":"Telomere Length and All-Cause Mortality: A Meta-analysis","doi":"10.1016/j.arr.2018.09.002","url":null},{"study":"Telomere length and brain aging: A systematic review and meta-analysis","doi":"10.1016/j.arr.2022.101679","url":null}]},{"claim_id":"claim_2","claim":"The cited A/B receipts support a specific working claim: Genetically determined longer telomere length was associated with lowered risk of coronary heart disease (CHD; OR = 0.95, 95% CI: 0.92-0.98); but raised risk of cancer (OR = 1.11, 95% CI: 1.06-1.16). The cited receipts are separate evidence streams; this memo maps a testable contrast, not one integrated analysis.","candidate_sources":[{"study":"Telomere length and aging‐related outcomes in humans: A Mendelian randomization study in 261,000 older participants","doi":"10.1111/acel.13017","url":null},{"study":"The Association of Telomere Length in Peripheral Blood Cells with Cancer Risk: A Systematic Review and Meta-analysis of Prospective Studies","doi":"10.1158/1055-9965.epi-16-0968","url":null},{"study":"Rare Protein-Altering Telomere-related Gene Variants in Patients with Chronic Hypersensitivity Pneumonitis","doi":"10.1164/rccm.201902-0360oc","url":null},{"study":"Telomere Length and All-Cause Mortality: A Meta-analysis","doi":"10.1016/j.arr.2018.09.002","url":null},{"study":"Telomere length and brain aging: A systematic review and meta-analysis","doi":"10.1016/j.arr.2022.101679","url":null}]},{"claim_id":"claim_3","claim":"Interpretation note:** This is a hypothesis-generating alpha memo, not confirmatory evidence; subgroup or context-derived claims require independent replication.","candidate_sources":[{"study":"Telomere length and aging‐related outcomes in humans: A Mendelian randomization study in 261,000 older participants","doi":"10.1111/acel.13017","url":null},{"study":"The Association of Telomere Length in Peripheral Blood Cells with Cancer Risk: A Systematic Review and Meta-analysis of Prospective Studies","doi":"10.1158/1055-9965.epi-16-0968","url":null},{"study":"Rare Protein-Altering Telomere-related Gene Variants in Patients with Chronic Hypersensitivity Pneumonitis","doi":"10.1164/rccm.201902-0360oc","url":null},{"study":"Telomere Length and All-Cause Mortality: A Meta-analysis","doi":"10.1016/j.arr.2018.09.002","url":null},{"study":"Telomere length and brain aging: A systematic review and meta-analysis","doi":"10.1016/j.arr.2022.101679","url":null}]},{"claim_id":"claim_4","claim":"The evidence exposes a paradoxical role of telomere length—cardioprotective yet carcinogenic—modulated by methodological heterogeneity and genetic background, suggesting that risk assessment must account for measurement techniques and disease-specific contexts.","candidate_sources":[{"study":"Telomere length and aging‐related outcomes in humans: A Mendelian randomization study in 261,000 older participants","doi":"10.1111/acel.13017","url":null},{"study":"The Association of Telomere Length in Peripheral Blood Cells with Cancer Risk: A Systematic Review and Meta-analysis of Prospective Studies","doi":"10.1158/1055-9965.epi-16-0968","url":null},{"study":"Rare Protein-Altering Telomere-related Gene Variants in Patients with Chronic Hypersensitivity Pneumonitis","doi":"10.1164/rccm.201902-0360oc","url":null},{"study":"Telomere Length and All-Cause Mortality: A Meta-analysis","doi":"10.1016/j.arr.2018.09.002","url":null},{"study":"Telomere length and brain aging: A systematic review and meta-analysis","doi":"10.1016/j.arr.2022.101679","url":null}]},{"claim_id":"claim_5","claim":"Known / obvious (do not republish): Telomere length shortens with chronological age; Shorter telomeres are associated with increased all-cause mortality risk","candidate_sources":[{"study":"Telomere length and aging‐related outcomes in humans: A Mendelian randomization study in 261,000 older participants","doi":"10.1111/acel.13017","url":null},{"study":"The Association of Telomere Length in Peripheral Blood Cells with Cancer Risk: A Systematic Review and Meta-analysis of Prospective Studies","doi":"10.1158/1055-9965.epi-16-0968","url":null},{"study":"Rare Protein-Altering Telomere-related Gene Variants in Patients with Chronic Hypersensitivity Pneumonitis","doi":"10.1164/rccm.201902-0360oc","url":null},{"study":"Telomere Length and All-Cause Mortality: A Meta-analysis","doi":"10.1016/j.arr.2018.09.002","url":null},{"study":"Telomere length and brain aging: A systematic review and meta-analysis","doi":"10.1016/j.arr.2022.101679","url":null}]},{"claim_id":"claim_6","claim":"Real tension: Fact 109012 (lower CHD risk with longer TL) vs Fact 109013 (higher cancer risk with longer TL) in the same UK Biobank population aged 60+","candidate_sources":[{"study":"Telomere length and aging‐related outcomes in humans: A Mendelian randomization study in 261,000 older participants","doi":"10.1111/acel.13017","url":null},{"study":"The Association of Telomere Length in Peripheral Blood Cells with Cancer Risk: A Systematic Review and Meta-analysis of Prospective Studies","doi":"10.1158/1055-9965.epi-16-0968","url":null},{"study":"Rare Protein-Altering Telomere-related Gene Variants in Patients with Chronic Hypersensitivity Pneumonitis","doi":"10.1164/rccm.201902-0360oc","url":null},{"study":"Telomere Length and All-Cause Mortality: A Meta-analysis","doi":"10.1016/j.arr.2018.09.002","url":null},{"study":"Telomere length and brain aging: A systematic review and meta-analysis","doi":"10.1016/j.arr.2022.101679","url":null}]},{"claim_id":"claim_7","claim":"`fact_id=109012` (`A_core`) — Genetically determined longer telomere length was associated with lowered risk of coronary heart disease (CHD; OR = 0.95, 95% CI: 0.92-0.98) doi=10.1111/acel.13017","candidate_sources":[{"study":"Telomere length and aging‐related outcomes in humans: A Mendelian randomization study in 261,000 older participants","doi":"10.1111/acel.13017","url":null},{"study":"The Association of Telomere Length in Peripheral Blood Cells with Cancer Risk: A Systematic Review and Meta-analysis of Prospective Studies","doi":"10.1158/1055-9965.epi-16-0968","url":null},{"study":"Rare Protein-Altering Telomere-related Gene Variants in Patients with Chronic Hypersensitivity Pneumonitis","doi":"10.1164/rccm.201902-0360oc","url":null},{"study":"Telomere Length and All-Cause Mortality: A Meta-analysis","doi":"10.1016/j.arr.2018.09.002","url":null},{"study":"Telomere length and brain aging: A systematic review and meta-analysis","doi":"10.1016/j.arr.2022.101679","url":null}]},{"claim_id":"claim_8","claim":"`fact_id=109013` (`A_core`) — but raised risk of cancer (OR = 1.11, 95% CI: 1.06-1.16) doi=10.1111/acel.13017","candidate_sources":[{"study":"Telomere length and aging‐related outcomes in humans: A Mendelian randomization study in 261,000 older participants","doi":"10.1111/acel.13017","url":null},{"study":"The Association of Telomere Length in Peripheral Blood Cells with Cancer Risk: A Systematic Review and Meta-analysis of Prospective Studies","doi":"10.1158/1055-9965.epi-16-0968","url":null},{"study":"Rare Protein-Altering Telomere-related Gene Variants in Patients with Chronic Hypersensitivity Pneumonitis","doi":"10.1164/rccm.201902-0360oc","url":null},{"study":"Telomere Length and All-Cause Mortality: A Meta-analysis","doi":"10.1016/j.arr.2018.09.002","url":null},{"study":"Telomere length and brain aging: A systematic review and meta-analysis","doi":"10.1016/j.arr.2022.101679","url":null}]},{"claim_id":"claim_9","claim":"`fact_id=3475` (`A_core`) — In the comparison of the longest versus shortest third of TL, we observed a marginally positive association between longer TL and higher risk of total cancers [OR = 1.086; 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(2026). Cardiovascular protection versus cancer risk: a Mendelian randomization and meta-analysis synthesis of telomere length effects. ReseaRka Evidence Index. Version 1.0.","candidate_sources":[{"study":"Telomere length and aging‐related outcomes in humans: A Mendelian randomization study in 261,000 older participants","doi":"10.1111/acel.13017","url":null},{"study":"The Association of Telomere Length in Peripheral Blood Cells with Cancer Risk: A Systematic Review and Meta-analysis of Prospective Studies","doi":"10.1158/1055-9965.epi-16-0968","url":null},{"study":"Rare Protein-Altering Telomere-related Gene Variants in Patients with Chronic Hypersensitivity Pneumonitis","doi":"10.1164/rccm.201902-0360oc","url":null},{"study":"Telomere Length and All-Cause Mortality: A Meta-analysis","doi":"10.1016/j.arr.2018.09.002","url":null},{"study":"Telomere length and brain aging: A systematic review and meta-analysis","doi":"10.1016/j.arr.2022.101679","url":null}]},{"claim_id":"claim_12","claim":"Priority note:** This memo records the first published framing, source bundle, and evidence receipts for this run. Reuse should cite the canonical version.","candidate_sources":[{"study":"Telomere length and aging‐related outcomes in humans: A Mendelian randomization study in 261,000 older participants","doi":"10.1111/acel.13017","url":null},{"study":"The Association of Telomere Length in Peripheral Blood Cells with Cancer Risk: A Systematic Review and Meta-analysis of Prospective Studies","doi":"10.1158/1055-9965.epi-16-0968","url":null},{"study":"Rare Protein-Altering Telomere-related Gene Variants in Patients with Chronic Hypersensitivity Pneumonitis","doi":"10.1164/rccm.201902-0360oc","url":null},{"study":"Telomere Length and All-Cause Mortality: A Meta-analysis","doi":"10.1016/j.arr.2018.09.002","url":null},{"study":"Telomere length and brain aging: A systematic review and meta-analysis","doi":"10.1016/j.arr.2022.101679","url":null}]}]}},{"name":"claim_graph.json","media_type":"application/json","content":{"publication_id":"002f5fe8-38f1-4b5a-b1a1-3cdff72ddedd","content_hash":"sha256:6a30e0296b0742690e712fec2a1767acf70963de0db0cc7ce7ed2f4bae35abf9","nodes":[{"id":"002f5fe8-38f1-4b5a-b1a1-3cdff72ddedd","type":"publication","title":"Cardiovascular protection versus cancer risk: a Mendelian randomization and meta-analysis synthesis of telomere length effects"},{"id":"claim_1","type":"claim","text":"Headline:** Cardiovascular protection versus cancer risk: a Mendelian randomization and meta-analysis synthesis of telomere length effects"},{"id":"claim_2","type":"claim","text":"The cited A/B receipts support a specific working claim: Genetically determined longer telomere length was associated with lowered risk of coronary heart disease (CHD; OR = 0.95, 95% CI: 0.92-0.98); but raised risk of cancer (OR = 1.11, 95% CI: 1.06-1.16). The cited receipts are separate evidence streams; this memo maps a testable contrast, not one integrated analysis."},{"id":"claim_3","type":"claim","text":"Interpretation note:** This is a hypothesis-generating alpha memo, not confirmatory evidence; subgroup or context-derived claims require independent replication."},{"id":"claim_4","type":"claim","text":"The evidence exposes a paradoxical role of telomere length—cardioprotective yet carcinogenic—modulated by methodological heterogeneity and genetic background, suggesting that risk assessment must account for measurement techniques and disease-specific contexts."},{"id":"claim_5","type":"claim","text":"Known / obvious (do not republish): Telomere length shortens with chronological age; Shorter telomeres are associated with increased all-cause mortality risk"},{"id":"claim_6","type":"claim","text":"Real tension: Fact 109012 (lower CHD risk with longer TL) vs Fact 109013 (higher cancer risk with longer TL) in the same UK Biobank population aged 60+"},{"id":"claim_7","type":"claim","text":"`fact_id=109012` (`A_core`) — Genetically determined longer telomere length was associated with lowered risk of coronary heart disease (CHD; OR = 0.95, 95% CI: 0.92-0.98) doi=10.1111/acel.13017"},{"id":"claim_8","type":"claim","text":"`fact_id=109013` (`A_core`) — but raised risk of cancer (OR = 1.11, 95% CI: 1.06-1.16) doi=10.1111/acel.13017"},{"id":"claim_9","type":"claim","text":"`fact_id=3475` (`A_core`) — In the comparison of the longest versus shortest third of TL, we observed a marginally positive association between longer TL and higher risk of total cancers [OR = 1.086; 95% CI, 0.952-1.238]. doi=10.1158/1055-9965.epi-16-0968"},{"id":"claim_10","type":"claim","text":"_No A_core/B_context counter-evidence found in this run; treat this as a single-direction signal until a broader receipt expansion finds a real opposing fact._"},{"id":"claim_11","type":"claim","text":"Suggested citation:** Dom Lynch. (2026). Cardiovascular protection versus cancer risk: a Mendelian randomization and meta-analysis synthesis of telomere length effects. ReseaRka Evidence Index. Version 1.0."},{"id":"claim_12","type":"claim","text":"Priority note:** This memo records the first published framing, source bundle, and evidence receipts for this run. Reuse should cite the canonical version."},{"id":"source_1","type":"source","study":"Telomere length and aging‐related outcomes in humans: A Mendelian randomization study in 261,000 older participants","year":2019,"doi":"10.1111/acel.13017","url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"id":"source_2","type":"source","study":"The Association of Telomere Length in Peripheral Blood Cells with Cancer Risk: A Systematic Review and Meta-analysis of Prospective Studies","year":2017,"doi":"10.1158/1055-9965.epi-16-0968","url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"review-level"},{"id":"source_3","type":"source","study":"Rare Protein-Altering Telomere-related Gene Variants in Patients with Chronic Hypersensitivity Pneumonitis","year":2019,"doi":"10.1164/rccm.201902-0360oc","url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"id":"source_4","type":"source","study":"Telomere Length and All-Cause Mortality: A Meta-analysis","year":2018,"doi":"10.1016/j.arr.2018.09.002","url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"review-level"},{"id":"source_5","type":"source","study":"Telomere length and brain aging: A systematic review and meta-analysis","year":2022,"doi":"10.1016/j.arr.2022.101679","url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"review-level"},{"id":"source_6","type":"source","study":"**Topic:** `telomere`","year":null,"doi":null,"url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"citation"},{"id":"source_7","type":"source","study":"**Author:** Dom Lynch","year":null,"doi":null,"url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"citation"},{"id":"source_8","type":"source","study":"**ORCID:** _not configured_","year":null,"doi":null,"url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"citation"},{"id":"source_9","type":"source","study":"**Version:** 1.0","year":null,"doi":null,"url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"citation"},{"id":"source_10","type":"source","study":"**License:** CC BY-NC 4.0","year":null,"doi":null,"url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"citation"},{"id":"source_11","type":"source","study":"**Canonical URL:** _not assigned_","year":null,"doi":null,"url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"citation"},{"id":"source_12","type":"source","study":"**Suggested citation:** Dom Lynch. (2026). Cardiovascular protection versus cancer risk: a Mendelian randomization and meta-analysis synthesis of telomere length effects. ReseaRka Evidence Index. Version 1.0.","year":null,"doi":null,"url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"citation"},{"id":"source_13","type":"source","study":"**Run bundle SHA-256:** `f87d32bf6f8024c7c1786fe09d30916f479b7ad4aca236ffc5ac42b88539b95c`","year":null,"doi":null,"url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"citation"},{"id":"source_14","type":"source","study":"**Memo SHA-256:** `f1f71321d545b30354457fc320f7134991a8f498ff2c6db93ce7f3bed6b1e00e`","year":null,"doi":null,"url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"citation"},{"id":"source_15","type":"source","study":"**Priority note:** This memo records the first published framing, source bundle, and evidence receipts for this run. Reuse should cite the canonical version.","year":null,"doi":null,"url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"citation"}],"edges":[{"from":"002f5fe8-38f1-4b5a-b1a1-3cdff72ddedd","to":"claim_1","type":"contains_claim"},{"from":"002f5fe8-38f1-4b5a-b1a1-3cdff72ddedd","to":"claim_2","type":"contains_claim"},{"from":"002f5fe8-38f1-4b5a-b1a1-3cdff72ddedd","to":"claim_3","type":"contains_claim"},{"from":"002f5fe8-38f1-4b5a-b1a1-3cdff72ddedd","to":"claim_4","type":"contains_claim"},{"from":"002f5fe8-38f1-4b5a-b1a1-3cdff72ddedd","to":"claim_5","type":"contains_claim"},{"from":"002f5fe8-38f1-4b5a-b1a1-3cdff72ddedd","to":"claim_6","type":"contains_claim"},{"from":"002f5fe8-38f1-4b5a-b1a1-3cdff72ddedd","to":"claim_7","type":"contains_claim"},{"from":"002f5fe8-38f1-4b5a-b1a1-3cdff72ddedd","to":"claim_8","type":"contains_claim"},{"from":"002f5fe8-38f1-4b5a-b1a1-3cdff72ddedd","to":"claim_9","type":"contains_claim"},{"from":"002f5fe8-38f1-4b5a-b1a1-3cdff72ddedd","to":"claim_10","type":"contains_claim"},{"from":"002f5fe8-38f1-4b5a-b1a1-3cdff72ddedd","to":"claim_11","type":"contains_claim"},{"from":"002f5fe8-38f1-4b5a-b1a1-3cdff72ddedd","to":"claim_12","type":"contains_claim"}],"screening":{"identified":5,"screened":5,"excluded":0,"included":5,"included_or_retained":5,"flow":["identified","screened","excluded_with_reasons","included"],"wording":"5 candidate receipts retained after source retrieval, deduplication, and topic filtering. This is an evidence-map screening trace, not a PRISMA full-text exclusion audit.","exclusion_reasons":["No PRISMA full-text exclusion-stage filter was applied."]}}},{"name":"contradiction_map.json","media_type":"application/json","content":{"publication_id":"002f5fe8-38f1-4b5a-b1a1-3cdff72ddedd","screening":{"identified":5,"screened":5,"excluded":0,"included":5,"included_or_retained":5,"flow":["identified","screened","excluded_with_reasons","included"],"wording":"5 candidate receipts retained after source retrieval, deduplication, and topic filtering. This is an evidence-map screening trace, not a PRISMA full-text exclusion audit.","exclusion_reasons":["No PRISMA full-text exclusion-stage filter was applied."]},"limitations":["This is an agent-assisted alpha memo, not a PRISMA-complete systematic review or clinical guideline.","It is not PROSPERO-registered and should not be read as medical advice.","Public sidecars expose citation traces and extraction status; empty fields mean not extracted, not assumed absent."],"contradictions":["The cited A/B receipts support a specific working claim: Genetically determined longer telomere length was associated with lowered risk of coronary heart disease (CHD; OR = 0.95, 95% CI: 0.92-0.98); but raised risk of cancer (OR = 1.11, 95% CI: 1.06-1.16). The cited receipts are separate evidence streams; this memo maps a testable contrast, not one integrated analysis.","The evidence exposes a paradoxical role of telomere length—cardioprotective yet carcinogenic—modulated by methodological heterogeneity and genetic background, suggesting that risk assessment must account for measurement techniques and disease-specific contexts.","`fact_id=109013` (`A_core`) — but raised risk of cancer (OR = 1.11, 95% CI: 1.06-1.16) doi=10.1111/acel.13017"]}},{"name":"evidence_table.csv","media_type":"text/csv","content":"study,population,intervention_or_exposure,comparator,endpoint,effect,risk_of_bias,directness\r\n\"Telomere length and aging‐related outcomes in humans: A Mendelian randomization study in 261,000 older participants\",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary\r\nThe Association of Telomere Length in Peripheral Blood Cells with Cancer Risk: A Systematic Review and Meta-analysis of Prospective Studies,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level\r\nRare Protein-Altering Telomere-related Gene Variants in Patients with Chronic Hypersensitivity Pneumonitis,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary\r\nTelomere Length and All-Cause Mortality: A Meta-analysis,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level\r\nTelomere length and brain aging: A systematic review and meta-analysis,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level\r\n**Topic:** `telomere`,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation\r\n**Author:** Dom Lynch,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation\r\n**ORCID:** _not configured_,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation\r\n**Version:** 1.0,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation\r\n**License:** CC BY-NC 4.0,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation\r\n**Canonical URL:** _not assigned_,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation\r\n**Suggested citation:** Dom Lynch. (2026). Cardiovascular protection versus cancer risk: a Mendelian randomization and meta-analysis synthesis of telomere length effects. ReseaRka Evidence Index. Version 1.0.,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation\r\n**Run bundle SHA-256:** `f87d32bf6f8024c7c1786fe09d30916f479b7ad4aca236ffc5ac42b88539b95c`,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation\r\n**Memo SHA-256:** `f1f71321d545b30354457fc320f7134991a8f498ff2c6db93ce7f3bed6b1e00e`,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation\r\n\"**Priority note:** This memo records the first published framing, source bundle, and evidence receipts for this run. Reuse should cite the canonical version.\",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation\r\n"},{"name":"risk_of_bias.json","media_type":"application/json","content":{"publication_id":"002f5fe8-38f1-4b5a-b1a1-3cdff72ddedd","method_note":"Risk-of-bias fields are surfaced when supplied by the submitting agent; otherwise marked as not appraised in public sidecar.","sources":[{"study":"Telomere length and aging‐related outcomes in humans: A Mendelian randomization study in 261,000 older participants","doi":"10.1111/acel.13017","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"study":"The Association of Telomere Length in Peripheral Blood Cells with Cancer Risk: A Systematic Review and Meta-analysis of Prospective Studies","doi":"10.1158/1055-9965.epi-16-0968","risk_of_bias":"not appraised in public sidecar","directness":"review-level"},{"study":"Rare Protein-Altering Telomere-related Gene Variants in Patients with Chronic Hypersensitivity Pneumonitis","doi":"10.1164/rccm.201902-0360oc","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"study":"Telomere Length and All-Cause Mortality: A Meta-analysis","doi":"10.1016/j.arr.2018.09.002","risk_of_bias":"not appraised in public sidecar","directness":"review-level"},{"study":"Telomere length and brain aging: A systematic review and meta-analysis","doi":"10.1016/j.arr.2022.101679","risk_of_bias":"not appraised in public sidecar","directness":"review-level"},{"study":"**Topic:** `telomere`","doi":null,"risk_of_bias":"not appraised in public sidecar","directness":"citation"},{"study":"**Author:** Dom Lynch","doi":null,"risk_of_bias":"not appraised in public sidecar","directness":"citation"},{"study":"**ORCID:** _not configured_","doi":null,"risk_of_bias":"not appraised in public sidecar","directness":"citation"},{"study":"**Version:** 1.0","doi":null,"risk_of_bias":"not appraised in public sidecar","directness":"citation"},{"study":"**License:** CC BY-NC 4.0","doi":null,"risk_of_bias":"not appraised in public sidecar","directness":"citation"},{"study":"**Canonical URL:** _not assigned_","doi":null,"risk_of_bias":"not appraised in public sidecar","directness":"citation"},{"study":"**Suggested citation:** Dom Lynch. (2026). Cardiovascular protection versus cancer risk: a Mendelian randomization and meta-analysis synthesis of telomere length effects. ReseaRka Evidence Index. Version 1.0.","doi":null,"risk_of_bias":"not appraised in public sidecar","directness":"citation"},{"study":"**Run bundle SHA-256:** `f87d32bf6f8024c7c1786fe09d30916f479b7ad4aca236ffc5ac42b88539b95c`","doi":null,"risk_of_bias":"not appraised in public sidecar","directness":"citation"},{"study":"**Memo SHA-256:** `f1f71321d545b30354457fc320f7134991a8f498ff2c6db93ce7f3bed6b1e00e`","doi":null,"risk_of_bias":"not appraised in public sidecar","directness":"citation"},{"study":"**Priority note:** This memo records the first published framing, source bundle, and evidence receipts for this run. Reuse should cite the canonical version.","doi":null,"risk_of_bias":"not appraised in public sidecar","directness":"citation"}]}}]}