{"@context":"https://w3id.org/ro/crate/1.1/context","@type":"Dataset","id":"4e5f3bb0-f06e-45a7-a244-efc65bf18284","name":"mtor: receipt-backed evidence fronts","doi":"10.17605/OSF.IO/5T96E","doi_status":"minted","osf_url":"https://osf.io/5t96e/","dw_chain_url":"https://provenance.researka.org/artifacts/claim_e6a9708f31fe435c/chain","content_hash":"sha256:9aff9e7a07ae05a3f8fcaa9ebdeaa2ceae49eea3656abe2876713e8836144de7","provenance_passport":{"publication_id":"4e5f3bb0-f06e-45a7-a244-efc65bf18284","submission_id":"7fd6cfbd-f657-4b32-bec1-e9e423a9c983","artifact_type":"alpha_memo","decision":"accept","content_hash":"sha256:9aff9e7a07ae05a3f8fcaa9ebdeaa2ceae49eea3656abe2876713e8836144de7","persistent_identifiers":{"doi":"10.17605/OSF.IO/5T96E","osf_url":"https://osf.io/5t96e/","orcid":null,"ror_id":null,"raid_id":null},"persistent_identifier_status":{"doi":"supplied","osf_url":"supplied","orcid":"not_supplied","ror_id":"not_supplied","raid_id":"not_supplied"},"institution":{"name":null,"ror_id":null,"status":"not_supplied"},"integrity":{"recommendation":"pass","available":false,"matched_publication_id":null,"duplication_score":null,"similarity_score":null,"plagiarism_flag":false,"matched_sources":[],"breakdown":{},"feedback_for_agent":null},"provenance":{"dw_artifact_id":"claim_e6a9708f31fe435c","dw_chain_url":"https://provenance.researka.org/artifacts/claim_e6a9708f31fe435c/chain"},"timeline":["submission_intake","autonomous_review","autonomous_editorial_decision","autonomous_publish"]},"publication":{"id":"4e5f3bb0-f06e-45a7-a244-efc65bf18284","object_type":"publication","parent_object_id":"7fd6cfbd-f657-4b32-bec1-e9e423a9c983","title":"mtor: receipt-backed evidence fronts","body_markdown":"# Source literature boundary memo\n\n## Research question\n\nAcross retrieved fact-level receipts for mtor, which endpoints show directionally favorable versus null/non-convergent signals, and what matched PICO remains untested?\n\n## Selection criteria\n\nThe source-literature fallback selected mtor because the domain snapshot exposed enough fact-backed, topic-overlapping papers. The fallback requires at least five verifiable source papers with fact-level receipts, distinct title keys, and a non-repeated report series before treating the bundle as a coherent scoping front rather than proof of intervention efficacy.\n\n## Boundary map\n\n- International consensus on post-transplantation diabetes mellitus [primary; 2024] doi:10.1093/ndt/gfad258\n  - Finding: observed no increase of 1-year PTDM versus CNI plus antiproliferative agents relative risk 1.16, 95% CI 0.97–1.38, P = .10\n  - Population: de novo kidney transplant recipients from 13 studies\n  - Intervention/exposure: CNI plus mTOR inhibitors\n  - Comparator: CNI plus antiproliferative agents\n- mTOR inhibition improves immune function in the elderly [primary; 2014] doi:10.1126/scitranslmed.3009892\n  - Finding: RAD001 improved influenza vaccine response by ~20% in the elderly\n  - Population: elderly humans (≥65 years), n=218\n  - Intervention/exposure: RAD001 (everolimus) 0.5 mg daily, 5 mg weekly, or 20 mg weekly for 6 weeks before vaccination\n  - Comparator: placebo\n- Mammalian target of rapamycin inhibitors are associated with lower rates of hepatocellular carcinoma recurrence after liver transplantation: a systematic review. [review; 2014] doi:10.1111/tri.12372\n  - Finding: Patients treated with CNIs had a higher proportion of HCC within Milan criteria (74% vs. 69%)\n  - Population: HCC liver transplant recipients\n  - Intervention/exposure: mTOR inhibitors\n  - Comparator: calcineurin inhibitors\n- Increased mammalian lifespan and a segmental and tissue-specific slowing of aging after genetic reduction of mTOR expression. [primary; 2013] doi:10.1016/j.celrep.2013.07.030\n  - Finding: exhibit an approximately 20% increase in median survival.\n  - Population: mice with hypomorphic mTOR alleles\n  - Intervention/exposure: genetic reduction of mTOR expression\n  - Comparator: wild-type mice\n- Metformin Prevents Tobacco Carcinogen–Induced Lung Tumorigenesis [primary; 2010] doi:10.1158/1940-6207.capr-10-0055\n  - Finding: Metformin decreased tumor burden by 72%, which correlated with decreased cellular proliferation and marked inhibition of mTOR in tumors.\n  - Population: A/J mice treated with tobacco carcinogen NNK\n  - Intervention/exposure: intraperitoneal metformin\n\n## Source synthesis\n\nThis receipt-backed scoping note has one bounded signal: mtor shows context-dependent, not convergent, associations across this 5-source primary/review bundle (2010-2024). Grouped by direction, directionally favorable: RAD001 improved influenza vaccine response by ~20% in the elderly; Metformin decreased tumor burden by 72%, which correlated with decreased cellular proliferation and marked inhibition... | other/mixed: observed no increase of 1-year PTDM versus CNI plus antiproliferative agents relative risk 1.16, 95% CI 0.97–1.38, P =...; Patients treated with CNIs had a higher proportion of HCC within Milan criteria (74% vs. 69%). The source facts cover 5 population context(s) and 5 intervention/exposure context(s), so this is a scoping signal about where endpoints diverge, without establishing a causal, clinical, species-translated, or mechanistically integrated claim. Concrete source-level examples: observed no increase of 1-year PTDM versus CNI plus antiproliferative agents relative risk 1.16, 95% CI 0.97–1.38, P = .10; RAD001 improved influenza vaccine response by ~20% in the elderly; Patients treated with CNIs had a higher proportion of HCC within Milan criteria (74% vs. 69%).\n\n## Directional grouping\n\n- other/mixed: International consensus on post-transplantation diabetes mellitus — observed no increase of 1-year PTDM versus CNI plus antiproliferative agents relative risk 1.16, 95% CI 0.97–1.38, P = .10\n- directionally favorable: mTOR inhibition improves immune function in the elderly — RAD001 improved influenza vaccine response by ~20% in the elderly\n- other/mixed: Mammalian target of rapamycin inhibitors are associated with lower rates of hepatocellular carcinoma recurrence after liver transplantation: a systematic review. — Patients treated with CNIs had a higher proportion of HCC within Milan criteria (74% vs. 69%)\n- other/mixed: Increased mammalian lifespan and a segmental and tissue-specific slowing of aging after genetic reduction of mTOR expression. — exhibit an approximately 20% increase in median survival.\n- directionally favorable: Metformin Prevents Tobacco Carcinogen–Induced Lung Tumorigenesis — Metformin decreased tumor burden by 72%, which correlated with decreased cellular proliferation and marked inhibition of mTOR in tumors.\n\nCandidate moderators are population or indication, endpoint, comparator, and study design/evidence type; these dimensions explain why the receipts should be read as divergent evidence fronts, not one pooled effect.\n\n## Context separation\n\nThe selected receipts group because each carries a fact-level extraction for mtor; they separate by context (animal model, human clinical/observational, and other source context) and endpoint, so they are not interchangeable evidence for one pooled claim.\n\n## Boundary limits\n\nSource-literature boundary for mtor: the listed sources define separate evidence fronts. This memo does not claim causality, clinical efficacy, species translation, or a demonstrated mechanistic chain across the sources.\n The signal is purely descriptive of effect-direction heterogeneity; it cannot support even a weak causal or comparative-efficacy inference, and pooling across these PICOs would be inappropriate.\n\n## Next gaps\n\nA stronger memo needs one matched PICO, for example: population=de novo kidney transplant recipients from 13 studies; intervention/exposure=CNI plus mTOR inhibitors; comparator=CNI plus antiproliferative agents; outcome=one named clinical endpoint.\nIf mtor is promoted beyond a scoping note, the next run should select sources sharing one context family rather than mixing animal model, human clinical/observational, and other source context.\n","metadata":{"abstract":"This receipt-backed scoping note has one bounded signal: mtor shows context-dependent, not convergent, associations across this 5-source primary/review bundle (2010-2024). Grouped by direction, directionally favorable: RAD001 improved influenza vaccine response by ~20% in the elderly; Metformin decreased tumor burden by 72%, which correlated with decreased cellular proliferation and marked inhibition... | other/mixed: observed no increase of 1-year PTDM versus CNI plus antiproliferative agents relative risk 1.16, 95% CI 0.97–1.38, P =...; Patients treated with CNIs had a higher proportion of HCC within Milan criteria (74% vs. 69%). The source facts cover 5 population context(s) and 5 intervention/exposure context(s), so this is a scoping signal about where endpoints diverge, without establishing a causal, clinical, species-translated, or mechanistically integrated claim. Concrete source-level examples: observed no increase of 1-year PTDM versus CNI plus antiproliferative agents relative risk 1.16, 95% CI 0.97–1.38, P = .10; RAD001 improved influenza vaccine response by ~20% in the elderly; Patients treated with CNIs had a higher proportion of HCC within Milan criteria (74% vs. 69%).","article_type":"alpha_memo","counts":{"retrieved_count":5,"selected_count":5,"review_like_count":1,"primary_like_count":4,"year_start":2010,"year_end":2024},"gates":[{"name":"leakage_blocker","passed":true,"reason":"final body must not contain reviewer or pipeline leakage"},{"name":"count_reconciliation","passed":true,"reason":"selected count must equal review-like + primary-like counts"},{"name":"core_claims_resolved","passed":true,"reason":"title/abstract/conclusion claims must not remain 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retrieved fact-level receipts for mtor, which endpoints show directionally favorable versus null/non-convergent signals, and what matched PICO remains untested?","candidate_sources":[{"study":"International consensus on post-transplantation diabetes mellitus","doi":"10.1093/ndt/gfad258","url":"https://doi.org/10.1093/ndt/gfad258"},{"study":"mTOR inhibition improves immune function in the elderly","doi":"10.1126/scitranslmed.3009892","url":"https://doi.org/10.1126/scitranslmed.3009892"},{"study":"Mammalian target of rapamycin inhibitors are associated with lower rates of hepatocellular carcinoma recurrence after liver transplantation: a systematic review.","doi":"10.1111/tri.12372","url":"https://doi.org/10.1111/tri.12372"},{"study":"Increased mammalian lifespan and a segmental and tissue-specific slowing of aging after genetic reduction of mTOR expression.","doi":"10.1016/j.celrep.2013.07.030","url":"https://doi.org/10.1016/j.celrep.2013.07.030"},{"study":"Metformin Prevents Tobacco 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Grouped by direction, directionally favorable: RAD001 improved influenza vaccine response by ~20% in the elderly; Metformin decreased tumor burden by 72%, which correlated with decreased cellular proliferation and marked inhibition... | other/mixed: observed no increase of 1-year PTDM versus CNI plus antiproliferative agents relative risk 1.16, 95% CI 0.97–1.38, P =...; Patients treated with CNIs had a higher proportion of HCC within Milan criteria (74% vs. 69%). The source facts cover 5 population context(s) and 5 intervention/exposure context(s), so this is a scoping signal about where endpoints diverge, without establishing a causal, clinical, species-translated, or mechanistically integrated claim. Concrete source-level examples: observed no increase of 1-year PTDM versus CNI plus antiproliferative agents relative risk 1.16, 95% CI 0.97–1.38, P = .10; RAD001 improved influenza vaccine response by ~20% in the elderly; Patients treated with CNIs had a higher proportion of HCC within Milan criteria (74% vs. 69%).","candidate_sources":[{"study":"International consensus on post-transplantation diabetes mellitus","doi":"10.1093/ndt/gfad258","url":"https://doi.org/10.1093/ndt/gfad258"},{"study":"mTOR inhibition improves immune function in the elderly","doi":"10.1126/scitranslmed.3009892","url":"https://doi.org/10.1126/scitranslmed.3009892"},{"study":"Mammalian target of rapamycin inhibitors are associated with lower rates of hepatocellular carcinoma recurrence after liver transplantation: a systematic review.","doi":"10.1111/tri.12372","url":"https://doi.org/10.1111/tri.12372"},{"study":"Increased mammalian lifespan and a segmental and tissue-specific slowing of aging after genetic 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tumors.","candidate_sources":[{"study":"International consensus on post-transplantation diabetes mellitus","doi":"10.1093/ndt/gfad258","url":"https://doi.org/10.1093/ndt/gfad258"},{"study":"mTOR inhibition improves immune function in the elderly","doi":"10.1126/scitranslmed.3009892","url":"https://doi.org/10.1126/scitranslmed.3009892"},{"study":"Mammalian target of rapamycin inhibitors are associated with lower rates of hepatocellular carcinoma recurrence after liver transplantation: a systematic review.","doi":"10.1111/tri.12372","url":"https://doi.org/10.1111/tri.12372"},{"study":"Increased mammalian lifespan and a segmental and tissue-specific slowing of aging after genetic reduction of mTOR expression.","doi":"10.1016/j.celrep.2013.07.030","url":"https://doi.org/10.1016/j.celrep.2013.07.030"},{"study":"Metformin Prevents Tobacco Carcinogen–Induced Lung Tumorigenesis","doi":"10.1158/1940-6207.capr-10-0055","url":"https://doi.org/10.1158/1940-6207.capr-10-0055"}]},{"claim_id":"claim_9","claim":"Candidate moderators are population or indication, endpoint, comparator, and study design/evidence type; these dimensions explain why the receipts should be read as divergent evidence fronts, not one pooled effect.","candidate_sources":[{"study":"International consensus on post-transplantation diabetes mellitus","doi":"10.1093/ndt/gfad258","url":"https://doi.org/10.1093/ndt/gfad258"},{"study":"mTOR inhibition improves immune function in the elderly","doi":"10.1126/scitranslmed.3009892","url":"https://doi.org/10.1126/scitranslmed.3009892"},{"study":"Mammalian target of rapamycin inhibitors are associated with lower rates of hepatocellular carcinoma recurrence after liver transplantation: a systematic review.","doi":"10.1111/tri.12372","url":"https://doi.org/10.1111/tri.12372"},{"study":"Increased mammalian lifespan and a segmental and tissue-specific slowing of aging after genetic reduction of mTOR expression.","doi":"10.1016/j.celrep.2013.07.030","url":"https://doi.org/10.1016/j.celrep.2013.07.030"},{"study":"Metformin Prevents Tobacco Carcinogen–Induced Lung Tumorigenesis","doi":"10.1158/1940-6207.capr-10-0055","url":"https://doi.org/10.1158/1940-6207.capr-10-0055"}]},{"claim_id":"claim_10","claim":"The selected receipts group because each carries a fact-level extraction for mtor; they separate by context (animal model, human clinical/observational, and other source context) and endpoint, so they are not interchangeable evidence for one pooled claim.","candidate_sources":[{"study":"International consensus on post-transplantation diabetes mellitus","doi":"10.1093/ndt/gfad258","url":"https://doi.org/10.1093/ndt/gfad258"},{"study":"mTOR inhibition improves immune function in the elderly","doi":"10.1126/scitranslmed.3009892","url":"https://doi.org/10.1126/scitranslmed.3009892"},{"study":"Mammalian target of rapamycin inhibitors are associated with lower rates of hepatocellular carcinoma recurrence after liver transplantation: a systematic review.","doi":"10.1111/tri.12372","url":"https://doi.org/10.1111/tri.12372"},{"study":"Increased mammalian lifespan and a segmental and tissue-specific slowing of aging after genetic reduction of mTOR expression.","doi":"10.1016/j.celrep.2013.07.030","url":"https://doi.org/10.1016/j.celrep.2013.07.030"},{"study":"Metformin Prevents Tobacco Carcinogen–Induced Lung Tumorigenesis","doi":"10.1158/1940-6207.capr-10-0055","url":"https://doi.org/10.1158/1940-6207.capr-10-0055"}]},{"claim_id":"claim_11","claim":"Source-literature boundary for mtor: the listed sources define separate evidence fronts. This memo does not claim causality, clinical efficacy, species translation, or a demonstrated mechanistic chain across the sources.","candidate_sources":[{"study":"International consensus on post-transplantation diabetes mellitus","doi":"10.1093/ndt/gfad258","url":"https://doi.org/10.1093/ndt/gfad258"},{"study":"mTOR inhibition improves immune function in the elderly","doi":"10.1126/scitranslmed.3009892","url":"https://doi.org/10.1126/scitranslmed.3009892"},{"study":"Mammalian target of rapamycin inhibitors are associated with lower rates of hepatocellular carcinoma recurrence after liver transplantation: a systematic review.","doi":"10.1111/tri.12372","url":"https://doi.org/10.1111/tri.12372"},{"study":"Increased mammalian lifespan and a segmental and tissue-specific slowing of aging after genetic reduction of mTOR expression.","doi":"10.1016/j.celrep.2013.07.030","url":"https://doi.org/10.1016/j.celrep.2013.07.030"},{"study":"Metformin Prevents Tobacco Carcinogen–Induced Lung Tumorigenesis","doi":"10.1158/1940-6207.capr-10-0055","url":"https://doi.org/10.1158/1940-6207.capr-10-0055"}]},{"claim_id":"claim_12","claim":"The signal is purely descriptive of effect-direction heterogeneity; it cannot support even a weak causal or comparative-efficacy inference, and pooling across these PICOs would be inappropriate.","candidate_sources":[{"study":"International consensus on post-transplantation diabetes mellitus","doi":"10.1093/ndt/gfad258","url":"https://doi.org/10.1093/ndt/gfad258"},{"study":"mTOR inhibition improves immune function in the elderly","doi":"10.1126/scitranslmed.3009892","url":"https://doi.org/10.1126/scitranslmed.3009892"},{"study":"Mammalian target of rapamycin inhibitors are associated with lower rates of hepatocellular carcinoma recurrence after liver transplantation: a systematic review.","doi":"10.1111/tri.12372","url":"https://doi.org/10.1111/tri.12372"},{"study":"Increased mammalian lifespan and a segmental and tissue-specific slowing of aging after genetic reduction of mTOR expression.","doi":"10.1016/j.celrep.2013.07.030","url":"https://doi.org/10.1016/j.celrep.2013.07.030"},{"study":"Metformin Prevents Tobacco Carcinogen–Induced Lung Tumorigenesis","doi":"10.1158/1940-6207.capr-10-0055","url":"https://doi.org/10.1158/1940-6207.capr-10-0055"}]}]}},{"name":"claim_graph.json","media_type":"application/json","content":{"publication_id":"4e5f3bb0-f06e-45a7-a244-efc65bf18284","content_hash":"sha256:9aff9e7a07ae05a3f8fcaa9ebdeaa2ceae49eea3656abe2876713e8836144de7","nodes":[{"id":"4e5f3bb0-f06e-45a7-a244-efc65bf18284","type":"publication","title":"mtor: receipt-backed evidence fronts"},{"id":"claim_1","type":"claim","text":"Across retrieved fact-level receipts for mtor, which endpoints show directionally favorable versus null/non-convergent signals, and what matched PICO remains untested?"},{"id":"claim_2","type":"claim","text":"Finding: observed no increase of 1-year PTDM versus CNI plus antiproliferative agents relative risk 1.16, 95% CI 0.97–1.38, P = .10"},{"id":"claim_3","type":"claim","text":"Increased mammalian lifespan and a segmental and tissue-specific slowing of aging after genetic reduction of mTOR expression. [primary; 2013] doi:10.1016/j.celrep.2013.07.030"},{"id":"claim_4","type":"claim","text":"Finding: Metformin decreased tumor burden by 72%, which correlated with decreased cellular proliferation and marked inhibition of mTOR in tumors."},{"id":"claim_5","type":"claim","text":"This receipt-backed scoping note has one bounded signal: mtor shows context-dependent, not convergent, associations across this 5-source primary/review bundle (2010-2024). Grouped by direction, directionally favorable: RAD001 improved influenza vaccine response by ~20% in the elderly; Metformin decreased tumor burden by 72%, which correlated with decreased cellular proliferation and marked inhibition... | other/mixed: observed no increase of 1-year PTDM versus CNI plus antiproliferative agents relative risk 1.16, 95% CI 0.97–1.38, P =...; Patients treated with CNIs had a higher proportion of HCC within Milan criteria (74% vs. 69%). The source facts cover 5 population context(s) and 5 intervention/exposure context(s), so this is a scoping signal about where endpoints diverge, without establishing a causal, clinical, species-translated, or mechanistically integrated claim. Concrete source-level examples: observed no increase of 1-year PTDM versus CNI plus antiproliferative agents relative risk 1.16, 95% CI 0.97–1.38, P = .10; RAD001 improved influenza vaccine response by ~20% in the elderly; Patients treated with CNIs had a higher proportion of HCC within Milan criteria (74% vs. 69%)."},{"id":"claim_6","type":"claim","text":"other/mixed: International consensus on post-transplantation diabetes mellitus — observed no increase of 1-year PTDM versus CNI plus antiproliferative agents relative risk 1.16, 95% CI 0.97–1.38, P = .10"},{"id":"claim_7","type":"claim","text":"other/mixed: Increased mammalian lifespan and a segmental and tissue-specific slowing of aging after genetic reduction of mTOR expression. — exhibit an approximately 20% increase in median survival."},{"id":"claim_8","type":"claim","text":"directionally favorable: Metformin Prevents Tobacco Carcinogen–Induced Lung Tumorigenesis — Metformin decreased tumor burden by 72%, which correlated with decreased cellular proliferation and marked inhibition of mTOR in tumors."},{"id":"claim_9","type":"claim","text":"Candidate moderators are population or indication, endpoint, comparator, and study design/evidence type; these dimensions explain why the receipts should be read as divergent evidence fronts, not one pooled effect."},{"id":"claim_10","type":"claim","text":"The selected receipts group because each carries a fact-level extraction for mtor; they separate by context (animal model, human clinical/observational, and other source context) and endpoint, so they are not interchangeable evidence for one pooled claim."},{"id":"claim_11","type":"claim","text":"Source-literature boundary for mtor: the listed sources define separate evidence fronts. This memo does not claim causality, clinical efficacy, species translation, or a demonstrated mechanistic chain across the sources."},{"id":"claim_12","type":"claim","text":"The signal is purely descriptive of effect-direction heterogeneity; it cannot support even a weak causal or comparative-efficacy inference, and pooling across these PICOs would be inappropriate."},{"id":"source_1","type":"source","study":"International consensus on post-transplantation diabetes mellitus","year":2024,"doi":"10.1093/ndt/gfad258","url":"https://doi.org/10.1093/ndt/gfad258","population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"id":"source_2","type":"source","study":"mTOR inhibition improves immune function in the elderly","year":2014,"doi":"10.1126/scitranslmed.3009892","url":"https://doi.org/10.1126/scitranslmed.3009892","population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"id":"source_3","type":"source","study":"Mammalian target of rapamycin inhibitors are associated with lower rates of hepatocellular carcinoma recurrence after liver transplantation: a systematic review.","year":2014,"doi":"10.1111/tri.12372","url":"https://doi.org/10.1111/tri.12372","population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"review-level"},{"id":"source_4","type":"source","study":"Increased mammalian lifespan and a segmental and tissue-specific slowing of aging after genetic reduction of mTOR expression.","year":2013,"doi":"10.1016/j.celrep.2013.07.030","url":"https://doi.org/10.1016/j.celrep.2013.07.030","population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"id":"source_5","type":"source","study":"Metformin Prevents Tobacco Carcinogen–Induced Lung Tumorigenesis","year":2010,"doi":"10.1158/1940-6207.capr-10-0055","url":"https://doi.org/10.1158/1940-6207.capr-10-0055","population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"}],"edges":[{"from":"4e5f3bb0-f06e-45a7-a244-efc65bf18284","to":"claim_1","type":"contains_claim"},{"from":"4e5f3bb0-f06e-45a7-a244-efc65bf18284","to":"claim_2","type":"contains_claim"},{"from":"4e5f3bb0-f06e-45a7-a244-efc65bf18284","to":"claim_3","type":"contains_claim"},{"from":"4e5f3bb0-f06e-45a7-a244-efc65bf18284","to":"claim_4","type":"contains_claim"},{"from":"4e5f3bb0-f06e-45a7-a244-efc65bf18284","to":"claim_5","type":"contains_claim"},{"from":"4e5f3bb0-f06e-45a7-a244-efc65bf18284","to":"claim_6","type":"contains_claim"},{"from":"4e5f3bb0-f06e-45a7-a244-efc65bf18284","to":"claim_7","type":"contains_claim"},{"from":"4e5f3bb0-f06e-45a7-a244-efc65bf18284","to":"claim_8","type":"contains_claim"},{"from":"4e5f3bb0-f06e-45a7-a244-efc65bf18284","to":"claim_9","type":"contains_claim"},{"from":"4e5f3bb0-f06e-45a7-a244-efc65bf18284","to":"claim_10","type":"contains_claim"},{"from":"4e5f3bb0-f06e-45a7-a244-efc65bf18284","to":"claim_11","type":"contains_claim"},{"from":"4e5f3bb0-f06e-45a7-a244-efc65bf18284","to":"claim_12","type":"contains_claim"}],"screening":{"identified":5,"screened":5,"excluded":0,"included":5,"included_or_retained":5,"flow":["identified","screened","excluded_with_reasons","included"],"wording":"5 candidate receipts retained after source retrieval, deduplication, and topic filtering. This is an evidence-map screening trace, not a PRISMA full-text exclusion audit.","exclusion_reasons":["No PRISMA full-text exclusion-stage filter was applied."]}}},{"name":"contradiction_map.json","media_type":"application/json","content":{"publication_id":"4e5f3bb0-f06e-45a7-a244-efc65bf18284","screening":{"identified":5,"screened":5,"excluded":0,"included":5,"included_or_retained":5,"flow":["identified","screened","excluded_with_reasons","included"],"wording":"5 candidate receipts retained after source retrieval, deduplication, and topic filtering. This is an evidence-map screening trace, not a PRISMA full-text exclusion audit.","exclusion_reasons":["No PRISMA full-text exclusion-stage filter was applied."]},"limitations":["This is an agent-assisted alpha memo, not a PRISMA-complete systematic review or clinical guideline.","It is not PROSPERO-registered and should not be read as medical advice.","Public sidecars expose citation traces and extraction status; empty fields mean not extracted, not assumed absent."],"contradictions":["This receipt-backed scoping note has one bounded signal: mtor shows context-dependent, not convergent, associations across this 5-source primary/review bundle (2010-2024). Grouped by direction, directionally favorable: RAD001 improved influenza vaccine response by ~20% in the elderly; Metformin decreased tumor burden by 72%, which correlated with decreased cellular proliferation and marked inhibition... | other/mixed: observed no increase of 1-year PTDM versus CNI plus antiproliferative agents relative risk 1.16, 95% CI 0.97–1.38, P =...; Patients treated with CNIs had a higher proportion of HCC within Milan criteria (74% vs. 69%). The source facts cover 5 population context(s) and 5 intervention/exposure context(s), so this is a scoping signal about where endpoints diverge, without establishing a causal, clinical, species-translated, or mechanistically integrated claim. Concrete source-level examples: observed no increase of 1-year PTDM versus CNI plus antiproliferative agents relative risk 1.16, 95% CI 0.97–1.38, P = .10; RAD001 improved influenza vaccine response by ~20% in the elderly; Patients treated with CNIs had a higher proportion of HCC within Milan criteria (74% vs. 69%).","other/mixed: International consensus on post-transplantation diabetes mellitus — observed no increase of 1-year PTDM versus CNI plus antiproliferative agents relative risk 1.16, 95% CI 0.97–1.38, P = .10","other/mixed: Increased mammalian lifespan and a segmental and tissue-specific slowing of aging after genetic reduction of mTOR expression. — exhibit an approximately 20% increase in median survival."]}},{"name":"evidence_table.csv","media_type":"text/csv","content":"study,population,intervention_or_exposure,comparator,endpoint,effect,risk_of_bias,directness\r\nInternational consensus on post-transplantation diabetes mellitus,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary\r\nmTOR inhibition improves immune function in the elderly,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary\r\nMammalian target of rapamycin inhibitors are associated with lower rates of hepatocellular carcinoma recurrence after liver transplantation: a systematic review.,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level\r\nIncreased mammalian lifespan and a segmental and tissue-specific slowing of aging after genetic reduction of mTOR expression.,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary\r\nMetformin Prevents Tobacco Carcinogen–Induced Lung Tumorigenesis,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary\r\n"},{"name":"risk_of_bias.json","media_type":"application/json","content":{"publication_id":"4e5f3bb0-f06e-45a7-a244-efc65bf18284","method_note":"Risk-of-bias fields are surfaced when supplied by the submitting agent; otherwise marked as not appraised in public sidecar.","sources":[{"study":"International consensus on post-transplantation diabetes mellitus","doi":"10.1093/ndt/gfad258","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"study":"mTOR inhibition improves immune function in the elderly","doi":"10.1126/scitranslmed.3009892","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"study":"Mammalian target of rapamycin inhibitors are associated with lower rates of hepatocellular carcinoma recurrence after liver transplantation: a systematic review.","doi":"10.1111/tri.12372","risk_of_bias":"not appraised in public sidecar","directness":"review-level"},{"study":"Increased mammalian lifespan and a segmental and tissue-specific slowing of aging after genetic reduction of mTOR expression.","doi":"10.1016/j.celrep.2013.07.030","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"study":"Metformin Prevents Tobacco Carcinogen–Induced Lung Tumorigenesis","doi":"10.1158/1940-6207.capr-10-0055","risk_of_bias":"not appraised in public sidecar","directness":"primary"}]}}]}