{"@context":"https://w3id.org/ro/crate/1.1/context","@type":"Dataset","id":"57cdda93-cf6f-4497-b8fa-c2a05a658c90","name":"Metformin treatment: evidence map — 19 findings across 19 sources","doi":"10.17605/OSF.IO/FTUHG","doi_status":"minted","osf_url":"https://osf.io/ftuhg/","dw_chain_url":"https://provenance.researka.org/artifacts/claim_6eda7f884117489f/chain","content_hash":"sha256:915a35888db397c2c4642bcbc0f9708438460e754406ca292c3c8a1a6e091cc6","provenance_passport":{"publication_id":"57cdda93-cf6f-4497-b8fa-c2a05a658c90","submission_id":"df8c4fe1-df75-46f4-8e15-5b6b8946b9f1","artifact_type":"alpha_memo","decision":"accept","content_hash":"sha256:915a35888db397c2c4642bcbc0f9708438460e754406ca292c3c8a1a6e091cc6","persistent_identifiers":{"doi":"10.17605/OSF.IO/FTUHG","osf_url":"https://osf.io/ftuhg/","orcid":null,"ror_id":null,"raid_id":null},"persistent_identifier_status":{"doi":"supplied","osf_url":"supplied","orcid":"not_supplied","ror_id":"not_supplied","raid_id":"not_supplied"},"institution":{"name":null,"ror_id":null,"status":"not_supplied"},"integrity":{"recommendation":"pass","available":false,"matched_publication_id":null,"duplication_score":null,"similarity_score":null,"plagiarism_flag":false,"matched_sources":[],"breakdown":{},"feedback_for_agent":null},"provenance":{"dw_artifact_id":"claim_6eda7f884117489f","dw_chain_url":"https://provenance.researka.org/artifacts/claim_6eda7f884117489f/chain"},"timeline":["submission_intake","autonomous_review","autonomous_editorial_decision","autonomous_publish"]},"publication":{"id":"57cdda93-cf6f-4497-b8fa-c2a05a658c90","object_type":"publication","parent_object_id":"df8c4fe1-df75-46f4-8e15-5b6b8946b9f1","title":"Metformin treatment: evidence map — 19 findings across 19 sources","body_markdown":"## Evidence Landscape\n\nThis evidence map surveys 19 independent metformin treatment sources drawn from the Tier-2 corpus and classified as direct findings. They vary across population, comparator, and/or endpoint and are catalogued by source in the Findings Map rather than pooled into one estimate — cross-population aggregation is not claimed. Each row records its own population, comparator, endpoint, and effect, so the spread of the literature and any tensions between findings remain explicit.\n\n## Findings Map\n\n| Population | Comparator | Finding | Source |\n|---|---|---|---|\n| individuals with DM | — | metformin treatment has also been associated with reductions in chylomicrons by up to 50% | 2025 doi:10.1007/s12325-025-03256-x |\n| Caenorhabditis elegans | control | Metformin causes an 86% increase in S-adenosylmethionine (SAMe) | 2025 doi:10.3390/ph18010055 |\n| participants in TAME trial | — | adequate power to detect a 20% reduction in the disease composite | 2025 doi:10.21203/rs.3.rs-5920485/v1 |\n| patients | — | its usage was discontinued in 5% of patients due to severe adverse effects | 2024 doi:10.1016/j.heliyon.2024.e37883 |\n| 24-month-old aged CB6F1 hybrid male mi… | young mice | mean expression of Lgr5 mRNA in the stem cluster from old mice... was restored back to 87%… | 2023 doi:10.1111/acel.13802 |\n| patients with T2D and metastatic lung… | those who did not take metfo… | patients treated with metformin had 20% higher survival rates than those who did not take… | 2022 doi:10.3892/or.2022.8266 |\n| patients with T2D with inadequate glyc… | — | least-squares mean change from baseline in HbA1c was -1.02% (-1.11, -0.93) in the dorzagli… | 2022 doi:10.1038/s41591-022-01803-5 |\n| sepsis patients with type 2 diabetes,… | — | 21.9% (418/1,907) for non-metformin users | 2021 doi:10.3389/fmed.2021.640785 |\n| nondiabetic patients with advanced-sta… | historical controls | relapse-free survival at 18 months of 59.3% (95% CI 38.6-70.5) | 2020 doi:10.1172/jci.insight.133247 |\n| patients with type 2 diabetes under me… | before and after treatment | vaspin, irisin, QUICKI, and eGDR (ACC = 86 [%]); | 2020 doi:10.3390/biom10091304 |\n| hospitalized COVID-19 patients with di… | no-metformin group | in-hospital mortality was significantly lower in the metformin group (3/104 (2.9%) versus… | 2020 doi:10.4269/ajtmh.20-0375 |\n| pharmacies in 17 countries | — | Lowest priced generic of metformin 500 mg had the highest total mean availability (≥80%) a… | 2019 doi:10.3389/fphar.2019.01375 |\n| patients with type 2 diabetes mellitus… | baseline | MRI-PDFF decreased significantly with sitagliptin (15.5% ± 5.6% to 11.7% ± 5.0%, P = 0.001… | 2018 doi:10.1002/hep.30320 |\n| patients in the high Met group | — | achieved this for the high Met group after treatment, with HbA1c of 6.8% | 2017 doi:10.1186/s12933-017-0607-6 |\n| genetically heterogeneous mice (ITP) | rapamycin alone (historical… | Metformin (0.1%) combined with rapamycin (14 ppm) robustly extended lifespan, suggestive o… | 2016 doi:10.1111/acel.12496 |\n| 1450 patients with type 2 diabetes rec… | glimepiride | HbA1c reduction at 1 year was 0.82% for canagliflozin 100 mg vs. 0.81% for glimepiride. | 2016 doi:10.1681/asn.2016030278 |\n| mice on high-fat diet | without metformin | Clostridium cocleatum (0.10%±0.09%) abundances increased significantly after metformin tre… | 2014 doi:10.1128/aem.01357-14 |\n| 342 overweight patients with newly dia… | — | this subgroup experienced a 39% (P = 0.010) risk reduction for myocardial infarction | 2011 doi:10.2337/dc10-2361 |\n| A/J mice treated with tobacco carcinog… | — | Metformin decreased tumor burden by 72%, which correlated with decreased cellular prolifer… | 2010 doi:10.1158/1940-6207.capr-10-0055 |\n\n## Limitations\n\nThis is a scoping map of retrieved direct findings, not a meta-analysis: no pooled effect is computed, coverage is bounded by the Tier-2 corpus, and heterogeneity across rows precludes a single unified conclusion.\n\n## Scope\n\nWhat is the range of reported effects across the metformin treatment literature, and how do they vary by population, comparator, and endpoint? This map catalogues the findings rather than converging them to one claim.\n\n## Search Summary\n\n19 direct (A_core) sources were retrieved from the Tier-2 semantic corpus for this topic and lane-classified; each is cited with a resolvable identifier in the source bundle below.\n\n## Tensions and Gaps\n\nFindings differ in population, comparator, endpoint, and effect size, so they are not directly comparable and are not pooled. Gaps remain where a population or comparator is represented by only a single source.\n","metadata":{"abstract":"Scoping review of Metformin treatment: 19 findings across 19 independent sources, catalogued by population, comparator, endpoint, and effect size. 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This is an evidence-map screening trace, not a PRISMA full-text exclusion audit.","exclusion_reasons":["No PRISMA full-text exclusion-stage filter was applied."]}}},{"name":"contradiction_map.json","media_type":"application/json","content":{"publication_id":"57cdda93-cf6f-4497-b8fa-c2a05a658c90","screening":{"identified":19,"screened":19,"excluded":0,"included":19,"included_or_retained":19,"flow":["identified","screened","excluded_with_reasons","included"],"wording":"19 candidate receipts retained after source retrieval, deduplication, and topic filtering. 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A Brief Narrative Review.\",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level\r\nThe Gut Microbiota-Related Antihyperglycemic Effect of Metformin,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary\r\nSelecting Appropriate Clinical Trial Endpoints for Geroscience Trials: A Path Towards Consensus.,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary\r\nGut aging: A wane from the normal to repercussion and gerotherapeutic strategies.,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary\r\nIntestinal stem cell aging at single‐cell resolution: Transcriptional perturbations alter cell developmental trajectory reversed by gerotherapeutics,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary\r\nAdvances in metformin‑based metabolic therapy for non‑small cell lung cancer (Review),not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level\r\n\"Dorzagliatin add-on therapy to metformin in patients with type 2 diabetes: a randomized, double-blind, placebo-controlled phase 3 trial\",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary\r\nAssociation Between Preadmission Metformin Use and Outcomes in Intensive Care Unit Patients With Sepsis and Type 2 Diabetes: A Cohort Study,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary\r\nPhase II clinical trial of metformin as a cancer stem cell-targeting agent in ovarian cancer,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary\r\n\"The Usefulness of Diagnostic Panels Based on Circulating Adipocytokines/Regulatory Peptides, Renal Function Tests, Insulin Resistance Indicators and Lipid-Carbohydrate Metabolism Parameters in Diagnosis and Prognosis of Type 2 Diabetes Mellitus with Obesity\",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary\r\nMetformin Treatment Was Associated with Decreased Mortality in COVID-19 Patients with Diabetes in a Retrospective Analysis,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary\r\n\"The Availability, Pricing, and Affordability of Essential Diabetes Medicines in 17 Low-, Middle-, and High-Income Countries\",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary\r\n\"Liraglutide, Sitagliptin, and Insulin Glargine Added to Metformin: The Effect on Body Weight and Intrahepatic Lipid in Patients With Type 2 Diabetes Mellitus and Nonalcoholic Fatty Liver Disease\",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary\r\n\"The effects of vildagliptin compared with metformin on vascular endothelial function and metabolic parameters: a randomized, controlled trial (Sapporo Athero-Incretin Study 3)\",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary\r\n\"Longer lifespan in male mice treated with a weakly estrogenic agonist, an antioxidant, an α‐glucosidase inhibitor or a Nrf2‐inducer\",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary\r\nCanagliflozin Slows Progression of Renal Function Decline Independently of Glycemic Effects,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary\r\nEffect of metformin on metabolic improvement and gut microbiota.,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary\r\nUse of Metformin in the Setting of Mild-to-Moderate Renal Insufficiency,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary\r\nMetformin Prevents Tobacco Carcinogen–Induced Lung Tumorigenesis,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary\r\n"},{"name":"risk_of_bias.json","media_type":"application/json","content":{"publication_id":"57cdda93-cf6f-4497-b8fa-c2a05a658c90","method_note":"Risk-of-bias fields are surfaced when supplied by the submitting agent; otherwise marked as not appraised in public sidecar.","sources":[{"study":"Metformin: Old Drug, New Therapeutic Potential in the Skin? 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