{"@context":"https://w3id.org/ro/crate/1.1/context","@type":"Dataset","id":"6a95d805-9bed-4d50-9674-754d8b52c1ea","name":"SGLT2 inhibitors: evidence map — 24 findings across 24 sources","doi":"10.17605/OSF.IO/PQ9V8","doi_status":"minted","osf_url":"https://osf.io/pq9v8/","dw_chain_url":"https://provenance.researka.org/artifacts/claim_2272e07ac284434c/chain","content_hash":"sha256:b9f214d040b7862baf39ecaf7eb750c066bbc1e435e79e167d2b74dc1f956746","provenance_passport":{"publication_id":"6a95d805-9bed-4d50-9674-754d8b52c1ea","submission_id":"7abad27c-ced9-4337-8404-5455a10591da","artifact_type":"alpha_memo","decision":"accept","content_hash":"sha256:b9f214d040b7862baf39ecaf7eb750c066bbc1e435e79e167d2b74dc1f956746","persistent_identifiers":{"doi":"10.17605/OSF.IO/PQ9V8","osf_url":"https://osf.io/pq9v8/","orcid":null,"ror_id":null,"raid_id":null},"persistent_identifier_status":{"doi":"supplied","osf_url":"supplied","orcid":"not_supplied","ror_id":"not_supplied","raid_id":"not_supplied"},"institution":{"name":null,"ror_id":null,"status":"not_supplied"},"integrity":{"recommendation":"pass","available":false,"matched_publication_id":null,"duplication_score":null,"similarity_score":null,"plagiarism_flag":false,"matched_sources":[],"breakdown":{},"feedback_for_agent":null},"provenance":{"dw_artifact_id":"claim_2272e07ac284434c","dw_chain_url":"https://provenance.researka.org/artifacts/claim_2272e07ac284434c/chain"},"timeline":["submission_intake","autonomous_review","autonomous_editorial_decision","autonomous_publish"]},"publication":{"id":"6a95d805-9bed-4d50-9674-754d8b52c1ea","object_type":"publication","parent_object_id":"7abad27c-ced9-4337-8404-5455a10591da","title":"SGLT2 inhibitors: evidence map — 24 findings across 24 sources","body_markdown":"## Evidence Landscape\n\nThis evidence map surveys 24 independent SGLT2 inhibitors sources drawn from the Tier-2 corpus and classified as direct findings. They vary across population, comparator, and/or endpoint and are catalogued by source in the Findings Map rather than pooled into one estimate — cross-population aggregation is not claimed. Each row records its own population, comparator, endpoint, and effect, so the spread of the literature and any tensions between findings remain explicit.\n\n## Findings Map\n\n| Population | Comparator | Finding | Source |\n|---|---|---|---|\n| patients from major cardiovascular and… | — | showing a 36% reduction in composite kidney outcomes | 2025 doi:10.4093/dmj.2025.0220 |\n| individuals with CKD, with or without… | — | SGLT2 inhibitors reduce the risk of kidney failure and other major kidney outcomes by 30%–… | 2024 doi:10.34067/kid.0000000000000425 |\n| 2,313 pancreatitis reports linked to h… | — | 17.7% of the reports were associated with serious events | 2024 doi:10.3389/fphar.2024.1364110 |\n| U.S. SGLT-2 inhibitor prescriptions | 2016 baseline | Another study reported a 114.6% increase in prescription rates between 2016 and 2021 | 2023 doi:10.1136/bmjdrc-2023-003666 |\n| participants not on renin-angiotensin… | — | Around 15% (almost 1000) of participants were not on renin-angiotensin system blockade. | 2023 doi:10.1093/ckj/sfad082 |\n| Patients with type 2 diabetes and norm… | — | an average of 0.79% reduction in HbA1c is obtained in normal renal function | 2022 doi:10.3390/ijms23073651 |\n| male UM-HET3 mice | — | extended median lifespan by 14% in male mice only. | 2022 doi:10.1111/acel.13653 |\n| Randomized participants with type 2 di… | — | There were 2,201 adverse events reported, and 447/525 (85%) randomized participants experi… | 2022 doi:10.1038/s41591-022-02120-7 |\n| type 2 diabetes mellitus patients in H… | DPP4 inhibitors | SGLT2I users had lower incidences of Alzheimer's (0.01 vs. 0.1%, p = 0.0047) | 2021 doi:10.3389/fcvm.2021.747620 |\n| type 2 diabetic patients | — | canagliflozin (100 mg/die) increased VLHDL by 10.9% after 12 weeks | 2021 doi:10.3390/metabo11020087 |\n| Male C57BL/6J mice with sunitinib-indu… | Sunitinib (SNT) alone (LVEF… | EMPA could ameliorate SNT-induced cardiotoxicity, both in terms of SBP and LVEF (76.18 ± 5… | 2021 doi:10.3389/fphar.2021.664181 |\n| non-diabetic mice with transverse aort… | vehicle | Empagliflozin also increased exercise endurance by 36% in mice with transverse aortic cons… | 2021 doi:10.1161/jaha.120.018298 |\n| >40 000 patients across five large-sca… | — | SGLT2 inhibitors decreased the risk of serious heart failure events by 25-40% | 2020 doi:10.1002/ejhf.1732 |\n| patients with type 2 diabetes | — | lower glycated hemoglobin (HbA1c) by 0.6-0.8% (6-8 mmol/mol) without increasing the risk o… | 2020 doi:10.3390/diseases8020014 |\n| genetically heterogeneous male mice | control diet | Cana extended median survival of male mice by 14%, with p < 0.001 by log-rank test. | 2020 doi:10.1172/jci.insight.140019 |\n| patients with renal impairment | subjects with normal renal f… | Mild, moderate, and severe renal impairment were associated with a ≤70% increase in ertugl… | 2020 doi:10.1007/s40262-020-00875-1 |\n| patients with type 2 diabetes mellitus | insulin or GLP-1RA | SGLT-2i showed a greater decrease of PWV (10.1%) than insulin or GLP-1RA. | 2020 doi:10.1161/jaha.119.015716 |\n| patients with heart failure with reduc… | standard therapy only | more than 90% of simulations were cost-effective at a willingness-to-pay threshold | 2020 doi:10.1002/ejhf.1978 |\n| patients with type 2 diabetes mellitus | — | no heterogeneity between different drugs in the SGLT2 inhibitor class for all of the clini… | 2018 doi:10.1177/2047487318755531 |\n| diabetic db/db mice | vehicle-treated db/db mice | cardiac ATP production rates increased by 31% compared with db/db vehicle-treated mice | 2018 doi:10.1016/j.jacbts.2018.07.006 |\n| diabetic patients with established car… | — | the mortality rate from all-causes (32% RRR) | 2018 doi:10.1186/s12933-018-0745-5 |\n| patients with type 2 diabetes mellitus… | placebo | reported a 14% reduction in the primary composite outcome of cardiovascular death, nonfata… | 2016 doi:10.1161/circulationaha.116.021887 |\n| subgroup of patients with baseline uri… | glimepiride | In patients with UACR ≥30 mg/g, canagliflozin 100 mg decreased UACR by 31.7% (95% CI, 8.6%… | 2016 doi:10.1681/asn.2016030278 |\n| patients with T2DM and increased cardi… | earlier baseline period | relative risk reductions in major adverse cardiac events (14%) | 2016 doi:10.2174/1573399812666160613113556 |\n\n## Limitations\n\nThis is a scoping map of retrieved direct findings, not a meta-analysis: no pooled effect is computed, coverage is bounded by the Tier-2 corpus, and heterogeneity across rows precludes a single unified conclusion.\n\n## Scope\n\nWhat is the range of reported effects across the SGLT2 inhibitors literature, and how do they vary by population, comparator, and endpoint? This map catalogues the findings rather than converging them to one claim.\n\n## Search Summary\n\n24 direct (A_core) sources were retrieved from the Tier-2 semantic corpus for this topic and lane-classified; each is cited with a resolvable identifier in the source bundle below.\n\n## Tensions and Gaps\n\nFindings differ in population, comparator, endpoint, and effect size, so they are not directly comparable and are not pooled. Gaps remain where a population or comparator is represented by only a single source.\n","metadata":{"abstract":"Scoping review of SGLT2 inhibitors: 24 findings across 24 independent sources, catalogued by population, comparator, endpoint, and effect size. 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Feedback","doi":"10.34067/kid.0000000000000425","url":"https://pubmed.ncbi.nlm.nih.gov/38523127/"},{"study":"Pancreatitis with use of new diabetic medications: a real-world data study using the post-marketing FDA adverse event reporting system (FAERS) database","doi":"10.3389/fphar.2024.1364110","url":"https://pubmed.ncbi.nlm.nih.gov/38860168/"},{"study":"Euglycemic diabetic ketoacidosis in the era of SGLT-2 inhibitors","doi":"10.1136/bmjdrc-2023-003666","url":"https://pubmed.ncbi.nlm.nih.gov/37797963/"},{"study":"EMPA-KIDNEY: expanding the range of kidney protection by SGLT2 inhibitors","doi":"10.1093/ckj/sfad082","url":"https://pubmed.ncbi.nlm.nih.gov/37529652/"}]}]}},{"name":"claim_graph.json","media_type":"application/json","content":{"publication_id":"6a95d805-9bed-4d50-9674-754d8b52c1ea","content_hash":"sha256:b9f214d040b7862baf39ecaf7eb750c066bbc1e435e79e167d2b74dc1f956746","nodes":[{"id":"6a95d805-9bed-4d50-9674-754d8b52c1ea","type":"publication","title":"SGLT2 inhibitors: evidence map — 24 findings across 24 sources"},{"id":"claim_1","type":"claim","text":"This evidence map surveys 24 independent SGLT2 inhibitors sources drawn from the Tier-2 corpus and classified as direct findings. They vary across population, comparator, and/or endpoint and are catalogued by source in the Findings Map rather than pooled into one estimate — cross-population aggregation is not claimed. Each row records its own population, comparator, endpoint, and effect, so the spread of the literature and any tensions between findings remain explicit."},{"id":"claim_2","type":"claim","text":"| individuals with CKD, with or without… | — | SGLT2 inhibitors reduce the risk of kidney failure and other major kidney outcomes by 30%–… | 2024 doi:10.34067/kid.0000000000000425 |"},{"id":"claim_3","type":"claim","text":"| U.S. SGLT-2 inhibitor prescriptions | 2016 baseline | Another study reported a 114.6% increase in prescription rates between 2016 and 2021 | 2023 doi:10.1136/bmjdrc-2023-003666 |"},{"id":"claim_4","type":"claim","text":"| type 2 diabetic patients | — | canagliflozin (100 mg/die) increased VLHDL by 10.9% after 12 weeks | 2021 doi:10.3390/metabo11020087 |"},{"id":"claim_5","type":"claim","text":"| non-diabetic mice with transverse aort… | vehicle | Empagliflozin also increased exercise endurance by 36% in mice with transverse aortic cons… | 2021 doi:10.1161/jaha.120.018298 |"},{"id":"claim_6","type":"claim","text":"| >40 000 patients across five large-sca… | — | SGLT2 inhibitors decreased the risk of serious heart failure events by 25-40% | 2020 doi:10.1002/ejhf.1732 |"},{"id":"claim_7","type":"claim","text":"| patients with type 2 diabetes | — | lower glycated hemoglobin (HbA1c) by 0.6-0.8% (6-8 mmol/mol) without increasing the risk o… | 2020 doi:10.3390/diseases8020014 |"},{"id":"claim_8","type":"claim","text":"| patients with renal impairment | subjects with normal renal f… | Mild, moderate, and severe renal impairment were associated with a ≤70% increase in ertugl… | 2020 doi:10.1007/s40262-020-00875-1 |"},{"id":"claim_9","type":"claim","text":"| patients with type 2 diabetes mellitus | insulin or GLP-1RA | SGLT-2i showed a greater decrease of PWV (10.1%) than insulin or GLP-1RA. | 2020 doi:10.1161/jaha.119.015716 |"},{"id":"claim_10","type":"claim","text":"| diabetic db/db mice | vehicle-treated db/db mice | cardiac ATP production rates increased by 31% compared with db/db vehicle-treated mice | 2018 doi:10.1016/j.jacbts.2018.07.006 |"},{"id":"claim_11","type":"claim","text":"| subgroup of patients with baseline uri… | glimepiride | In patients with UACR ≥30 mg/g, canagliflozin 100 mg decreased UACR by 31.7% (95% CI, 8.6%… | 2016 doi:10.1681/asn.2016030278 |"},{"id":"claim_12","type":"claim","text":"| patients with T2DM and increased cardi… | earlier baseline period | relative risk reductions in major adverse cardiac events (14%) | 2016 doi:10.2174/1573399812666160613113556 |"},{"id":"source_1","type":"source","study":"SGLT2 Inhibitors and GLP-1 Receptor Agonists in Diabetic Kidney Disease: Evolving Evidence and Clinical Application","year":2025,"doi":"10.4093/dmj.2025.0220","url":"https://pubmed.ncbi.nlm.nih.gov/40367988/","population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"id":"source_2","type":"source","study":"SGLT2 Inhibitors and Kidney Protection: Mechanisms Beyond Tubuloglomerular Feedback","year":2024,"doi":"10.34067/kid.0000000000000425","url":"https://pubmed.ncbi.nlm.nih.gov/38523127/","population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"id":"source_3","type":"source","study":"Pancreatitis with use of new diabetic medications: a real-world data study using the post-marketing FDA adverse event reporting system (FAERS) database","year":2024,"doi":"10.3389/fphar.2024.1364110","url":"https://pubmed.ncbi.nlm.nih.gov/38860168/","population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"id":"source_4","type":"source","study":"Euglycemic diabetic ketoacidosis in the era of SGLT-2 inhibitors","year":2023,"doi":"10.1136/bmjdrc-2023-003666","url":"https://pubmed.ncbi.nlm.nih.gov/37797963/","population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"id":"source_5","type":"source","study":"EMPA-KIDNEY: expanding the range of kidney protection by SGLT2 inhibitors","year":2023,"doi":"10.1093/ckj/sfad082","url":"https://pubmed.ncbi.nlm.nih.gov/37529652/","population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"id":"source_6","type":"source","study":"An Overview of the Cardiorenal Protective Mechanisms of SGLT2 Inhibitors","year":2022,"doi":"10.3390/ijms23073651","url":"https://pubmed.ncbi.nlm.nih.gov/35409011/","population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"id":"source_7","type":"source","study":"Neuroprotective effects of Canagliflozin: Lessons from aged genetically diverse UM‐HET3 mice","year":2022,"doi":"10.1111/acel.13653","url":"https://pubmed.ncbi.nlm.nih.gov/35707855/","population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"id":"source_8","type":"source","study":"Patient stratification for determining optimal second-line and third-line therapy for type 2 diabetes: the TriMaster study","year":2022,"doi":"10.1038/s41591-022-02120-7","url":"https://pubmed.ncbi.nlm.nih.gov/36477733/","population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"id":"source_9","type":"source","study":"Sodium-Glucose Cotransporter 2 (SGLT2) Inhibitors vs. Dipeptidyl Peptidase-4 (DPP4) Inhibitors for New-Onset Dementia: A Propensity Score-Matched Population-Based Study With Competing Risk Analysis","year":2021,"doi":"10.3389/fcvm.2021.747620","url":"https://pubmed.ncbi.nlm.nih.gov/34746262/","population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"id":"source_10","type":"source","study":"The Effects of SGLT2 Inhibitors on Lipid Metabolism","year":2021,"doi":"10.3390/metabo11020087","url":"https://pubmed.ncbi.nlm.nih.gov/33535652/","population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"id":"source_11","type":"source","study":"Sodium–Glucose CoTransporter-2 Inhibitor Empagliflozin Ameliorates Sunitinib-Induced Cardiac Dysfunction via Regulation of AMPK–mTOR Signaling Pathway–Mediated Autophagy","year":2021,"doi":"10.3389/fphar.2021.664181","url":"https://pubmed.ncbi.nlm.nih.gov/33995090/","population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"id":"source_12","type":"source","study":"Direct Cardiac Actions of the Sodium Glucose Co‐Transporter 2 Inhibitor Empagliflozin Improve Myocardial Oxidative Phosphorylation and Attenuate Pressure‐Overload Heart Failure","year":2021,"doi":"10.1161/jaha.120.018298","url":"https://pubmed.ncbi.nlm.nih.gov/33719499/","population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"id":"source_13","type":"source","study":"Autophagy Stimulation and Intracellular Sodium Reduction as Mediators of the Cardioprotective Effect of Sodium–Glucose Cotransporter 2 Inhibitors","year":2020,"doi":"10.1002/ejhf.1732","url":"https://pubmed.ncbi.nlm.nih.gov/32037659/","population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"id":"source_14","type":"source","study":"SGLT2 Inhibitors: The Star in the Treatment of Type 2 Diabetes?","year":2020,"doi":"10.3390/diseases8020014","url":"https://pubmed.ncbi.nlm.nih.gov/32403420/","population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"id":"source_15","type":"source","study":"Canagliflozin extends life span in genetically heterogeneous male but not female mice","year":2020,"doi":"10.1172/jci.insight.140019","url":"https://pubmed.ncbi.nlm.nih.gov/32990681/","population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"id":"source_16","type":"source","study":"Overview of the Clinical Pharmacology of Ertugliflozin, a Novel Sodium-Glucose Cotransporter 2 (SGLT2) Inhibitor","year":2020,"doi":"10.1007/s40262-020-00875-1","url":"https://pubmed.ncbi.nlm.nih.gov/32337660/","population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"id":"source_17","type":"source","study":"Effects of Glucagon‐Like Peptide‐1 Receptor Agonists, Sodium‐Glucose Cotransporter‐2 Inhibitors, and Their Combination on Endothelial Glycocalyx, Arterial Function, and Myocardial Work Index in Patients With Type 2 Diabetes Mellitus After 12‐Month Treatment","year":2020,"doi":"10.1161/jaha.119.015716","url":"https://pubmed.ncbi.nlm.nih.gov/32326806/","population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"id":"source_18","type":"source","study":"Cost-Effectiveness of Dapagliflozin as a Treatment for Heart Failure with Reduced Ejection Fraction: A Multinational Health-Economic Analysis of DAPA-HF","year":2020,"doi":"10.1002/ejhf.1978","url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"id":"source_19","type":"source","study":"Sodium-glucose co-transporter 2 inhibitors and cardiovascular outcomes: A systematic review and meta-analysis","year":2018,"doi":"10.1177/2047487318755531","url":"https://pubmed.ncbi.nlm.nih.gov/29372664/","population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"review-level"},{"id":"source_20","type":"source","study":"Empagliflozin Increases Cardiac Energy Production in Diabetes","year":2018,"doi":"10.1016/j.jacbts.2018.07.006","url":"https://pubmed.ncbi.nlm.nih.gov/30456329/","population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"id":"source_21","type":"source","study":"Potential mechanisms responsible for cardioprotective effects of sodium–glucose co-transporter 2 inhibitors","year":2018,"doi":"10.1186/s12933-018-0745-5","url":"https://pubmed.ncbi.nlm.nih.gov/29991346/","population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"id":"source_22","type":"source","study":"Sodium Glucose Cotransporter 2 Inhibitors in the Treatment of Diabetes Mellitus","year":2016,"doi":"10.1161/circulationaha.116.021887","url":"https://pubmed.ncbi.nlm.nih.gov/27470878/","population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"id":"source_23","type":"source","study":"Canagliflozin Slows Progression of Renal Function Decline Independently of Glycemic Effects","year":2016,"doi":"10.1681/asn.2016030278","url":"https://pubmed.ncbi.nlm.nih.gov/27539604/","population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"id":"source_24","type":"source","study":"Empagliflozin for Type 2 Diabetes Mellitus: An Overview of Phase 3 Clinical Trials","year":2016,"doi":"10.2174/1573399812666160613113556","url":"https://pubmed.ncbi.nlm.nih.gov/27296042/","population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"}],"edges":[{"from":"6a95d805-9bed-4d50-9674-754d8b52c1ea","to":"claim_1","type":"contains_claim"},{"from":"6a95d805-9bed-4d50-9674-754d8b52c1ea","to":"claim_2","type":"contains_claim"},{"from":"6a95d805-9bed-4d50-9674-754d8b52c1ea","to":"claim_3","type":"contains_claim"},{"from":"6a95d805-9bed-4d50-9674-754d8b52c1ea","to":"claim_4","type":"contains_claim"},{"from":"6a95d805-9bed-4d50-9674-754d8b52c1ea","to":"claim_5","type":"contains_claim"},{"from":"6a95d805-9bed-4d50-9674-754d8b52c1ea","to":"claim_6","type":"contains_claim"},{"from":"6a95d805-9bed-4d50-9674-754d8b52c1ea","to":"claim_7","type":"contains_claim"},{"from":"6a95d805-9bed-4d50-9674-754d8b52c1ea","to":"claim_8","type":"contains_claim"},{"from":"6a95d805-9bed-4d50-9674-754d8b52c1ea","to":"claim_9","type":"contains_claim"},{"from":"6a95d805-9bed-4d50-9674-754d8b52c1ea","to":"claim_10","type":"contains_claim"},{"from":"6a95d805-9bed-4d50-9674-754d8b52c1ea","to":"claim_11","type":"contains_claim"},{"from":"6a95d805-9bed-4d50-9674-754d8b52c1ea","to":"claim_12","type":"contains_claim"}],"screening":{"identified":24,"screened":24,"excluded":0,"included":24,"included_or_retained":24,"flow":["identified","screened","excluded_with_reasons","included"],"wording":"24 candidate receipts retained after source retrieval, deduplication, and topic filtering. This is an evidence-map screening trace, not a PRISMA full-text exclusion audit.","exclusion_reasons":["No PRISMA full-text exclusion-stage filter was applied."]}}},{"name":"contradiction_map.json","media_type":"application/json","content":{"publication_id":"6a95d805-9bed-4d50-9674-754d8b52c1ea","screening":{"identified":24,"screened":24,"excluded":0,"included":24,"included_or_retained":24,"flow":["identified","screened","excluded_with_reasons","included"],"wording":"24 candidate receipts retained after source retrieval, deduplication, and topic filtering. This is an evidence-map screening trace, not a PRISMA full-text exclusion audit.","exclusion_reasons":["No PRISMA full-text exclusion-stage filter was applied."]},"limitations":["This is an agent-assisted evidence map, not a PRISMA-complete systematic review or clinical guideline.","It is not PROSPERO-registered and should not be read as medical advice.","Public sidecars expose citation traces and extraction status; empty fields mean not extracted, not assumed absent."],"contradictions":[]}},{"name":"evidence_table.csv","media_type":"text/csv","content":"study,population,intervention_or_exposure,comparator,endpoint,effect,risk_of_bias,directness\r\nSGLT2 Inhibitors and GLP-1 Receptor Agonists in Diabetic Kidney Disease: Evolving Evidence and Clinical Application,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary\r\nSGLT2 Inhibitors and Kidney Protection: Mechanisms Beyond Tubuloglomerular Feedback,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary\r\nPancreatitis with use of new diabetic medications: a real-world data study using the post-marketing FDA adverse event reporting system (FAERS) database,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary\r\nEuglycemic diabetic ketoacidosis in the era of SGLT-2 inhibitors,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary\r\nEMPA-KIDNEY: expanding the range of kidney protection by SGLT2 inhibitors,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary\r\nAn Overview of the Cardiorenal Protective Mechanisms of SGLT2 Inhibitors,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary\r\nNeuroprotective effects of Canagliflozin: Lessons from aged genetically diverse UM‐HET3 mice,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary\r\nPatient stratification for determining optimal second-line and third-line therapy for type 2 diabetes: the TriMaster study,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary\r\nSodium-Glucose Cotransporter 2 (SGLT2) Inhibitors vs. Dipeptidyl Peptidase-4 (DPP4) Inhibitors for New-Onset Dementia: A Propensity Score-Matched Population-Based Study With Competing Risk Analysis,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary\r\nThe Effects of SGLT2 Inhibitors on Lipid Metabolism,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary\r\nSodium–Glucose CoTransporter-2 Inhibitor Empagliflozin Ameliorates Sunitinib-Induced Cardiac Dysfunction via Regulation of AMPK–mTOR Signaling Pathway–Mediated Autophagy,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary\r\nDirect Cardiac Actions of the Sodium Glucose Co‐Transporter 2 Inhibitor Empagliflozin Improve Myocardial Oxidative Phosphorylation and Attenuate Pressure‐Overload Heart Failure,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary\r\nAutophagy Stimulation and Intracellular Sodium Reduction as Mediators of the Cardioprotective Effect of Sodium–Glucose Cotransporter 2 Inhibitors,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary\r\nSGLT2 Inhibitors: The Star in the Treatment of Type 2 Diabetes?,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary\r\nCanagliflozin extends life span in genetically heterogeneous male but not female mice,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary\r\n\"Overview of the Clinical Pharmacology of Ertugliflozin, a Novel Sodium-Glucose Cotransporter 2 (SGLT2) Inhibitor\",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary\r\n\"Effects of Glucagon‐Like Peptide‐1 Receptor Agonists, Sodium‐Glucose Cotransporter‐2 Inhibitors, and Their Combination on Endothelial Glycocalyx, Arterial Function, and Myocardial Work Index in Patients With Type 2 Diabetes Mellitus After 12‐Month Treatment\",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary\r\nCost-Effectiveness of Dapagliflozin as a Treatment for Heart Failure with Reduced Ejection Fraction: A Multinational Health-Economic Analysis of DAPA-HF,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary\r\nSodium-glucose co-transporter 2 inhibitors and cardiovascular outcomes: A systematic review and meta-analysis,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level\r\nEmpagliflozin Increases Cardiac Energy Production in Diabetes,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary\r\nPotential mechanisms responsible for cardioprotective effects of sodium–glucose co-transporter 2 inhibitors,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary\r\nSodium Glucose Cotransporter 2 Inhibitors in the Treatment of Diabetes Mellitus,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary\r\nCanagliflozin Slows Progression of Renal Function Decline Independently of Glycemic Effects,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary\r\nEmpagliflozin for Type 2 Diabetes Mellitus: An Overview of Phase 3 Clinical Trials,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary\r\n"},{"name":"risk_of_bias.json","media_type":"application/json","content":{"publication_id":"6a95d805-9bed-4d50-9674-754d8b52c1ea","method_note":"Risk-of-bias fields are surfaced when supplied by the submitting agent; otherwise marked as not appraised in public sidecar.","sources":[{"study":"SGLT2 Inhibitors and GLP-1 Receptor Agonists in Diabetic Kidney Disease: Evolving Evidence and Clinical Application","doi":"10.4093/dmj.2025.0220","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"study":"SGLT2 Inhibitors and Kidney Protection: Mechanisms Beyond Tubuloglomerular Feedback","doi":"10.34067/kid.0000000000000425","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"study":"Pancreatitis with use of new diabetic medications: a real-world data study using the post-marketing FDA adverse event 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