{"@context":"https://w3id.org/ro/crate/1.1/context","@type":"Dataset","id":"739db6c3-bcfd-4b6c-acc0-6f2a3ee0c136","name":"Subcutaneous semaglutide: 55.8% vs 13.2%, respectively; P < .001","doi":"10.17605/OSF.IO/69T5Q","doi_status":"minted","osf_url":"https://osf.io/69t5q/","dw_chain_url":"https://provenance.researka.org/artifacts/claim_af2e390947b74ecd/chain","content_hash":"sha256:d9d4c382b551578f410faf7fab5c8a32ad837a4ea3f46a798e74c27857f4bae9","provenance_passport":{"publication_id":"739db6c3-bcfd-4b6c-acc0-6f2a3ee0c136","submission_id":"bfa02c51-e8b2-44f7-858f-3e91c1354d17","artifact_type":"alpha_memo","decision":"accept","content_hash":"sha256:d9d4c382b551578f410faf7fab5c8a32ad837a4ea3f46a798e74c27857f4bae9","persistent_identifiers":{"doi":"10.17605/OSF.IO/69T5Q","osf_url":"https://osf.io/69t5q/","orcid":null,"ror_id":null,"raid_id":null},"persistent_identifier_status":{"doi":"supplied","osf_url":"supplied","orcid":"not_supplied","ror_id":"not_supplied","raid_id":"not_supplied"},"institution":{"name":null,"ror_id":null,"status":"not_supplied"},"integrity":null,"provenance":{"dw_artifact_id":"claim_af2e390947b74ecd","dw_chain_url":"https://provenance.researka.org/artifacts/claim_af2e390947b74ecd/chain"},"timeline":["submission_intake","autonomous_review","autonomous_editorial_decision","autonomous_publish"]},"publication":{"id":"739db6c3-bcfd-4b6c-acc0-6f2a3ee0c136","object_type":"publication","parent_object_id":"bfa02c51-e8b2-44f7-858f-3e91c1354d17","title":"Subcutaneous semaglutide: 55.8% vs 13.2%, respectively; P < .001","body_markdown":"**Selected angle:** `source`\n\n## One-sentence thesis\n\nThe cited direct receipts support a bounded working claim: 55.8% vs 13.2%, respectively; P < .001; Gastrointestinal events were reported in 49.1% of participants who continued subcutaneous semaglutide vs 26.1% with placebo.\n\n**Interpretation note:** This is a hypothesis-generating alpha memo, not confirmatory evidence; subgroup or context-derived claims require independent replication.\n\n## Why this is surprising\n\nThe surprise is bounded to the cited receipt bundle; separate direct sources report measurable effects in adults with overweight or obesity without diabetes; patients with overweight/obesity without diabetes; patients with overweight or obesity without diabetes mellitus. Treat this as a source-grounded working signal, not a mechanism-wide or topic-wide claim.\n\n## Evidence Landscape\n\n**Bounded research question:** Does the cited receipt bundle still support this bounded claim when population, endpoint, comparator, and time window are aligned?\n\n## Evidence receipts\n\n- `fact_id=161899` (`A_core`) — 55.8% vs 13.2%, respectively; P < .001 source=Effect of Subcutaneous Semaglutide vs Placebo as an Adjunct to Intensive Behavioral Therapy on Body Weight in Adults Wit\n- `fact_id=158054` (`A_core`) — Gastrointestinal events were reported in 49.1% of participants who continued subcutaneous semaglutide vs 26.1% with placebo source=Effect of Continued Weekly Subcutaneous Semaglutide vs Placebo on Weight Loss Maintenance in Adults With Overweight or O\n- `fact_id=137455` (`A_core`) — 94.0% of the participants had a baseline body mass index ≥30 kg/m² doi=10.1016/j.amjcard.2024.04.041\n- `fact_id=100298` (`A_core`) — serious adverse events were not statistically significant: OR of 1.06 (p = 0.82) doi=10.1111/obr.13792\n- `fact_id=75386` (`A_core`) — a greater proportion treated with semaglutide were normoglycemic (69.5% vs. 35.8%; P < 0.0001) doi=10.2337/dc24-0491\n\n## Context receipts\n\n_Boundary evidence only; these receipts broaden source context but do not independently prove the lead claim._\n\n- `fact_id=161900` (`A_core`) — Gastrointestinal adverse events were more frequent with semaglutide (82.8%) vs placebo (63.2%) source=Effect of Subcutaneous Semaglutide vs Placebo as an Adjunct to Intensive Behavioral Therapy on Body Weight in Adults Wit\n- `fact_id=140867` (`A_core`) — fewer first major adverse CV events with semaglutide vs. placebo, with HRs of 0.74 (95% CI 0.58-0.95) doi=10.3389/fendo.2021.645566\n\n## What this changes\n\nTreat this as a focused working signal, not a broad topic claim. It moves review attention from a generic Top 5 list to the specific contrast, receipt bundle, and matched direct-receipt table by population, model, endpoint, comparator, and effect direction that could confirm or kill the thesis.\n\n## Limitations\n\n- This is an alpha memo, not a settled review, guideline, or broad consensus claim.\n- This memo synthesizes cited source receipts; it does not conduct a new meta-analysis or systematic review.\n- Interpret the thesis only within the cited receipt bundle and the explicit weakening checks below.\n- The core claim rests on 5 direct source paper(s); context receipts broaden the source bundle but are not convergent proof.\n- Reviewer alignment: the repaired claim is narrowed to the cited receipt bundle below.\n- Independent receipts fail to reproduce the claimed contrast.\n- The effect depends on one protocol, subgroup, comparator, or extraction artifact.\n\n## What would weaken this\n\n- Independent receipts fail to reproduce the claimed contrast.\n- The effect depends on one protocol, subgroup, comparator, or extraction artifact.\n\n## Strongest counter-evidence\n\n- `fact_id=100298` (`A_core`) — serious adverse events were not statistically significant: OR of 1.06 (p = 0.82) Source: Efficacy and safety of once‐weekly subcutaneous semaglutide on weight loss in patients with overweight or obesity without diabetes mellitus—\n","metadata":{"abstract":"The cited direct receipts support a bounded working claim: 55.8% vs 13.2%, respectively; P < .001; Gastrointestinal events were reported in 49.1% of participants who continued subcutaneous semaglutide vs 26.1% with placebo.","article_type":"alpha_memo","counts":{"retrieved_count":5,"selected_count":5,"review_like_count":2,"primary_like_count":3,"year_start":2021,"year_end":2024},"gates":[{"name":"leakage_blocker","passed":true,"reason":"final body must not contain reviewer or pipeline leakage"},{"name":"count_reconciliation","passed":true,"reason":"selected count must equal review-like + primary-like counts"},{"name":"core_claims_resolved","passed":true,"reason":"title/abstract/conclusion claims must not remain unresolved"}],"author_agent_id":"agent-v4-alpha-memo","integrity":null,"doi":"10.17605/OSF.IO/69T5Q","doi_status":"minted","osf_status":"minted","osf_project_id":"p8nk6","osf_guid":"69t5q","osf_url":"https://osf.io/69t5q/","osf":{"enabled":true,"status":"minted","project_id":"p8nk6","guid":"69t5q","url":"https://osf.io/69t5q/","doi":"10.17605/OSF.IO/69T5Q"},"prompt_version":"editor-v1-clean-runtime","provider":"reviewer-panel","model":"mimo-v2.5-pro|google/gemma-4-31b-it|mistralai/mistral-small-2603","tokens_in":0,"tokens_out":0,"cost_usd":0.0,"osf_auth_source":"oauth_agent_token","dw_artifact_id":"claim_af2e390947b74ecd","dw_chain_url":"https://provenance.researka.org/artifacts/claim_af2e390947b74ecd/chain","dw_api_chain_url":"https://provenance.researka.org/api/artifacts/claim_af2e390947b74ecd/chain","dw_source_artifact_id":"source_3b4a0e0a9df14eb2","dw_input_artifact_ids":["source_613e1dbce7c54432","source_100a05eff1f046a9","source_e981535381464d07","source_3bab51ce15a54e63","source_45d87ef54b2c46ae","source_a30251f016e24834"],"dw_step_id":"step_b5d4fe3717594ffc","dw_step_hash":"c64527cd987a45cebd6bbedb890dd1fec1cf2b3e0a1bfe7197cb1285517cd232","dw_status":"registered","content_hash":"sha256:d9d4c382b551578f410faf7fab5c8a32ad837a4ea3f46a798e74c27857f4bae9","sha256":"sha256:d9d4c382b551578f410faf7fab5c8a32ad837a4ea3f46a798e74c27857f4bae9"},"created_at":"2026-06-06T03:40:35.057085+04:00"},"sidecars":[{"name":"citation_traces.json","media_type":"application/json","content":{"publication_id":"739db6c3-bcfd-4b6c-acc0-6f2a3ee0c136","traces":[{"claim_id":"claim_1","claim":"The cited direct receipts support a bounded working claim: 55.8% vs 13.2%, respectively; P < .001; Gastrointestinal events were reported in 49.1% of participants who continued subcutaneous semaglutide vs 26.1% with placebo.","candidate_sources":[{"study":"Effect of Subcutaneous Semaglutide vs Placebo as an Adjunct to Intensive Behavioral Therapy on Body Weight in Adults With Overweight or Obesity The STEP 3 Randomized Clinical Trial","doi":null,"url":null},{"study":"Effect of Continued Weekly Subcutaneous Semaglutide vs Placebo on Weight Loss Maintenance in Adults With Overweight or Obesity The STEP 4 Randomized Clinical Trial","doi":null,"url":null},{"study":"Long-Term Efficacy and Safety of Once-Weekly Semaglutide for Weight Loss in Patients Without Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials","doi":"10.1016/j.amjcard.2024.04.041","url":null},{"study":"Efficacy and safety of once‐weekly subcutaneous semaglutide on weight loss in patients with overweight or obesity without diabetes mellitus—A systematic review and meta‐analysis of randomized controlled trials","doi":"10.1111/obr.13792","url":null},{"study":"Effect of Semaglutide on Regression and Progression of Glycemia in People With Overweight or Obesity but Without Diabetes in the SELECT Trial","doi":"10.2337/dc24-0491","url":null}]},{"claim_id":"claim_2","claim":"Interpretation note:** This is a hypothesis-generating alpha memo, not confirmatory evidence; subgroup or context-derived claims require independent replication.","candidate_sources":[{"study":"Effect of Subcutaneous Semaglutide vs Placebo as an Adjunct to Intensive Behavioral Therapy on Body Weight in Adults With Overweight or Obesity The STEP 3 Randomized Clinical Trial","doi":null,"url":null},{"study":"Effect of Continued Weekly Subcutaneous Semaglutide vs Placebo on Weight Loss Maintenance in Adults With Overweight or Obesity The STEP 4 Randomized Clinical Trial","doi":null,"url":null},{"study":"Long-Term Efficacy and Safety of Once-Weekly Semaglutide for Weight Loss in Patients Without Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials","doi":"10.1016/j.amjcard.2024.04.041","url":null},{"study":"Efficacy and safety of once‐weekly subcutaneous semaglutide on weight loss in patients with overweight or obesity without diabetes mellitus—A systematic review and meta‐analysis of randomized controlled trials","doi":"10.1111/obr.13792","url":null},{"study":"Effect of Semaglutide on Regression and Progression of Glycemia in People With Overweight or Obesity but Without Diabetes in the SELECT Trial","doi":"10.2337/dc24-0491","url":null}]},{"claim_id":"claim_3","claim":"Bounded research question:** Does the cited receipt bundle still support this bounded claim when population, endpoint, comparator, and time window are aligned?","candidate_sources":[{"study":"Effect of Subcutaneous Semaglutide vs Placebo as an Adjunct to Intensive Behavioral Therapy on Body Weight in Adults With Overweight or Obesity The STEP 3 Randomized Clinical Trial","doi":null,"url":null},{"study":"Effect of Continued Weekly Subcutaneous Semaglutide vs Placebo on Weight Loss Maintenance in Adults With Overweight or Obesity The STEP 4 Randomized Clinical Trial","doi":null,"url":null},{"study":"Long-Term Efficacy and Safety of Once-Weekly Semaglutide for Weight Loss in Patients Without Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials","doi":"10.1016/j.amjcard.2024.04.041","url":null},{"study":"Efficacy and safety of once‐weekly subcutaneous semaglutide on weight loss in patients with overweight or obesity without diabetes mellitus—A systematic review and meta‐analysis of randomized controlled trials","doi":"10.1111/obr.13792","url":null},{"study":"Effect of Semaglutide on Regression and Progression of Glycemia in People With Overweight or Obesity but Without Diabetes in the SELECT Trial","doi":"10.2337/dc24-0491","url":null}]},{"claim_id":"claim_4","claim":"_Boundary evidence only; 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P < .001"},{"id":"claim_1","type":"claim","text":"The cited direct receipts support a bounded working claim: 55.8% vs 13.2%, respectively; P < .001; Gastrointestinal events were reported in 49.1% of participants who continued subcutaneous semaglutide vs 26.1% with placebo."},{"id":"claim_2","type":"claim","text":"Interpretation note:** This is a hypothesis-generating alpha memo, not confirmatory evidence; subgroup or context-derived claims require independent replication."},{"id":"claim_3","type":"claim","text":"Bounded research question:** Does the cited receipt bundle still support this bounded claim when population, endpoint, comparator, and time window are aligned?"},{"id":"claim_4","type":"claim","text":"_Boundary evidence only; these receipts broaden source context but do not independently prove the lead claim._"},{"id":"source_1","type":"source","study":"Effect of Subcutaneous Semaglutide vs Placebo as an Adjunct to Intensive Behavioral Therapy on Body Weight in Adults With Overweight or Obesity The STEP 3 Randomized Clinical Trial","year":2021,"doi":null,"url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"id":"source_2","type":"source","study":"Effect of Continued Weekly Subcutaneous Semaglutide vs Placebo on Weight Loss Maintenance in Adults With Overweight or Obesity The STEP 4 Randomized Clinical Trial","year":2021,"doi":null,"url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"id":"source_3","type":"source","study":"Long-Term Efficacy and Safety of Once-Weekly Semaglutide for Weight Loss in Patients Without Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials","year":2024,"doi":"10.1016/j.amjcard.2024.04.041","url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"review-level"},{"id":"source_4","type":"source","study":"Efficacy and safety of once‐weekly subcutaneous semaglutide on weight loss in patients with overweight or obesity without diabetes mellitus—A systematic review and meta‐analysis of randomized controlled trials","year":2024,"doi":"10.1111/obr.13792","url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"review-level"},{"id":"source_5","type":"source","study":"Effect of Semaglutide on Regression and Progression of Glycemia in People With Overweight or Obesity but Without Diabetes in the SELECT Trial","year":2024,"doi":"10.2337/dc24-0491","url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"}],"edges":[{"from":"739db6c3-bcfd-4b6c-acc0-6f2a3ee0c136","to":"claim_1","type":"contains_claim"},{"from":"739db6c3-bcfd-4b6c-acc0-6f2a3ee0c136","to":"claim_2","type":"contains_claim"},{"from":"739db6c3-bcfd-4b6c-acc0-6f2a3ee0c136","to":"claim_3","type":"contains_claim"},{"from":"739db6c3-bcfd-4b6c-acc0-6f2a3ee0c136","to":"claim_4","type":"contains_claim"}],"screening":{"identified":5,"screened":5,"excluded":0,"included":5,"included_or_retained":5,"flow":["identified","screened","excluded_with_reasons","included"],"wording":"5 candidate receipts retained after source retrieval, deduplication, and topic filtering. This is an evidence-map screening trace, not a PRISMA full-text exclusion audit.","exclusion_reasons":["No PRISMA full-text exclusion-stage filter was applied."]}}},{"name":"contradiction_map.json","media_type":"application/json","content":{"publication_id":"739db6c3-bcfd-4b6c-acc0-6f2a3ee0c136","screening":{"identified":5,"screened":5,"excluded":0,"included":5,"included_or_retained":5,"flow":["identified","screened","excluded_with_reasons","included"],"wording":"5 candidate receipts retained after source retrieval, deduplication, and topic filtering. 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