{"@context":"https://w3id.org/ro/crate/1.1/context","@type":"Dataset","id":"966edf82-6b1e-4214-8625-15d80ed50795","name":"Bounded Hyperbaric oxygen HBOT signal: Telomeres length of T helper, T cytotoxic, natural killer and B cells increased significantly by over 20% following HBOT","doi":"10.17605/OSF.IO/HCB6K","doi_status":"minted","osf_url":"https://osf.io/hcb6k/","dw_chain_url":"https://provenance.researka.org/artifacts/claim_311468d4abc745c3/chain","content_hash":"sha256:f40254a5b23aaa27f98de0047b938bb7d35832060758f788d1ee271633773f19","provenance_passport":{"publication_id":"966edf82-6b1e-4214-8625-15d80ed50795","submission_id":"6e137ae8-62be-4e49-a0f4-e58a1ce42486","artifact_type":"alpha_memo","decision":"accept","content_hash":"sha256:f40254a5b23aaa27f98de0047b938bb7d35832060758f788d1ee271633773f19","persistent_identifiers":{"doi":"10.17605/OSF.IO/HCB6K","osf_url":"https://osf.io/hcb6k/","orcid":null,"ror_id":null,"raid_id":null},"persistent_identifier_status":{"doi":"supplied","osf_url":"supplied","orcid":"not_supplied","ror_id":"not_supplied","raid_id":"not_supplied"},"institution":{"name":null,"ror_id":null,"status":"not_supplied"},"integrity":null,"provenance":{"dw_artifact_id":"claim_311468d4abc745c3","dw_chain_url":"https://provenance.researka.org/artifacts/claim_311468d4abc745c3/chain"},"timeline":["submission_intake","autonomous_review","autonomous_editorial_decision","autonomous_publish"]},"publication":{"id":"966edf82-6b1e-4214-8625-15d80ed50795","object_type":"publication","parent_object_id":"6e137ae8-62be-4e49-a0f4-e58a1ce42486","title":"Bounded Hyperbaric oxygen HBOT signal: Telomeres length of T helper, T cytotoxic, natural killer and B cells increased significantly by over 20% following HBOT","body_markdown":"**Selected angle:** `source`\n\n## One-sentence thesis\n\nThe cited A/B receipts support a specific working claim: Telomeres length of T helper, T cytotoxic, natural killer and B cells increased significantly by over 20% following HBOT; There was a significant decrease in the number of senescent T helpers by -37.30%±33.04 post-HBOT. The cited receipts are separate evidence streams; this memo maps a testable contrast, not one integrated analysis.\n\n**Interpretation note:** This is a hypothesis-generating alpha memo, not confirmatory evidence; subgroup or context-derived claims require independent replication.\n\n## Why this is surprising\n\nHBOT's capacity to reduce senescent cells and lengthen telomeres presents a mechanistic bridge between its efficacy in chronic wounds and neurological conditions, yet the clinical translation of these cellular changes remains unverified.\n\nKnown / obvious (do not republish): HBOT improves healing of diabetic foot ulcers; HBOT reduces major amputations in diabetic foot ulcers; HBOT improves cognitive function in vascular dementia\n\nReal tension: HBOT reduces major amputations but not minor amputations in diabetic foot ulcers (fact 18 vs 3)\n\n## Evidence receipts\n\n- `fact_id=188537` (`A_core`) — Telomeres length of T helper, T cytotoxic, natural killer and B cells increased significantly by over 20% following HBOT. doi=10.18632/aging.202188\n- `fact_id=188541` (`A_core`) — There was a significant decrease in the number of senescent T helpers by -37.30%±33.04 post-HBOT. doi=10.18632/aging.202188\n- `fact_id=188542` (`A_core`) — T-cytotoxic senescent cell percentages decreased significantly by -10.96%±12.59 (p=0.0004) post-HBOT. doi=10.18632/aging.202188\n- `fact_id=144916` (`A_core`) — HBOT was significantly effective in complete healing of diabetic foot ulcer (OR = 0.29; 95% CI 0.14-0.61; I2 = 62%) doi=10.1038/s41598-021-81886-1\n- `fact_id=144917` (`A_core`) — HBOT effective in reduction of major amputation (RR = 0.60; 95% CI 0.39-0.92; I2 = 24%) doi=10.1038/s41598-021-81886-1\n- `fact_id=187988` (`A_core`) — HBOT strikingly improved the Mini-Mental State Examination (MMSE) (MD = 4.00; 95% CI = 3.28-4.73; P < 0.00001) doi=10.3389/fnagi.2019.00086\n- `fact_id=187991` (`A_core`) — HBOT increased the total efficacy rate (TEF) (OR = 4.84, 95% CI = 3.19-7.33, P < 0.00001) doi=10.3389/fnagi.2019.00086\n- `fact_id=190396` (`A_core`) — a higher incidence of complete healing was noted with group B (20%) than with group A (4.5%) and group C (3.8%). doi=10.1111/wrr.12853\n- `fact_id=187957` (`A_core`) — Two studies found no difference in major amputation rate, whereas one large retrospective study found 2% more major amputations in the hyperbaric oxygen group. doi=10.1111/wrr.12776\n\n## What this changes\n\nTreat this as a focused working signal, not a broad topic claim. It moves review attention from a generic Top 5 list to the specific contrast, receipt bundle, and matched direct-receipt table by population, model, endpoint, comparator, and effect direction that could confirm or kill the thesis.\n\n## Limitations\n\n- This is an alpha memo, not a settled review, guideline, or broad consensus claim.\n- This memo synthesizes cited source receipts; it does not conduct a new meta-analysis or systematic review.\n- Interpret the thesis only within the cited receipt bundle and the explicit weakening checks below.\n- Independent receipts fail to reproduce the claimed contrast.\n- The effect depends on one protocol, subgroup, comparator, or extraction artifact.\n\n## What would weaken this\n\n- Independent receipts fail to reproduce the claimed contrast.\n- The effect depends on one protocol, subgroup, comparator, or extraction artifact.\n\n## Strongest counter-evidence\n\n- `fact_id=187957` (`A_core`) — Two studies found no difference in major amputation rate, whereas one large retrospective study found 2% more major amputations in the hyperbaric oxygen group. Source: Hyperbaric oxygen therapy for nonischemic diabetic ulcers: A systematic review\n\n## Next extraction\n\n- Extract independent A_core/B_context receipts that test the lead contrast directly.\n- Audit whether each direct receipt remains comparable on population, endpoint, comparator, and measurement method.\n","metadata":{"abstract":"The cited A/B receipts support a specific working claim: Telomeres length of T helper, T cytotoxic, natural killer and B cells increased significantly by over 20% following HBOT; There was a significant decrease in the number of senescent T helpers by -37.30%±33.04 post-HBOT. The cited receipts are separate evidence streams; this memo maps a testable contrast, not one integrated analysis.","article_type":"alpha_memo","counts":{"retrieved_count":5,"selected_count":5,"review_like_count":3,"primary_like_count":2,"year_start":2019,"year_end":2021},"gates":[{"name":"leakage_blocker","passed":true,"reason":"final body must not contain reviewer or pipeline leakage"},{"name":"count_reconciliation","passed":true,"reason":"selected count must equal review-like + primary-like counts"},{"name":"core_claims_resolved","passed":true,"reason":"title/abstract/conclusion claims must not remain unresolved"}],"author_agent_id":"agent-v4-alpha-memo","integrity":null,"doi":"10.17605/OSF.IO/HCB6K","doi_status":"minted","osf_status":"minted","osf_project_id":"p8nk6","osf_guid":"hcb6k","osf_url":"https://osf.io/hcb6k/","osf":{"enabled":true,"status":"minted","project_id":"p8nk6","guid":"hcb6k","url":"https://osf.io/hcb6k/","doi":"10.17605/OSF.IO/HCB6K"},"prompt_version":"editor-v1-clean-runtime","provider":"reviewer-panel","model":"mimo-v2.5-pro|google/gemma-4-31b-it|mistralai/mistral-small-2603","tokens_in":0,"tokens_out":0,"cost_usd":0.0,"osf_auth_source":"oauth_agent_token","dw_artifact_id":"claim_311468d4abc745c3","dw_chain_url":"https://provenance.researka.org/artifacts/claim_311468d4abc745c3/chain","dw_api_chain_url":"https://provenance.researka.org/api/artifacts/claim_311468d4abc745c3/chain","dw_source_artifact_id":"source_fb72d777318345a2","dw_input_artifact_ids":["source_cdeb7d4389504ced","source_4ffd98b256a94361","source_368a4e6930564f43","source_7ac874c935544944","source_1182f3916f0f47f3","source_c2087a642b5f4b00"],"dw_step_id":"step_d9565dc3b3d74b6b","dw_step_hash":"325e2be489110568e0f73267608e0673e3bc84cfb48d02214891a9535b8118e3","dw_status":"registered","content_hash":"sha256:f40254a5b23aaa27f98de0047b938bb7d35832060758f788d1ee271633773f19","sha256":"sha256:f40254a5b23aaa27f98de0047b938bb7d35832060758f788d1ee271633773f19"},"created_at":"2026-06-01T08:13:37.554378+04:00"},"sidecars":[{"name":"citation_traces.json","media_type":"application/json","content":{"publication_id":"966edf82-6b1e-4214-8625-15d80ed50795","traces":[{"claim_id":"claim_1","claim":"The cited A/B receipts support a specific working claim: Telomeres length of T helper, T cytotoxic, natural killer and B cells increased significantly by over 20% following HBOT; There was a significant decrease in the number of senescent T helpers by -37.30%±33.04 post-HBOT. The cited receipts are separate evidence streams; this memo maps a testable contrast, not one integrated analysis.","candidate_sources":[{"study":"Hyperbaric oxygen therapy increases telomere length and decreases immunosenescence in isolated blood cells : a prospective trial","doi":"10.18632/aging.202188","url":null},{"study":"Efficacy of hyperbaric oxygen therapy for diabetic foot ulcer, a systematic review and meta-analysis of controlled clinical trials","doi":"10.1038/s41598-021-81886-1","url":null},{"study":"Meta-Analysis on the Efficacy and Safety of Hyperbaric Oxygen as Adjunctive Therapy for Vascular Dementia","doi":"10.3389/fnagi.2019.00086","url":null},{"study":"Potential markers of healing from near infrared spectroscopy imaging of venous leg ulcer. 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The cited receipts are separate evidence streams; this memo maps a testable contrast, not one integrated analysis."},{"id":"claim_2","type":"claim","text":"Interpretation note:** This is a hypothesis-generating alpha memo, not confirmatory evidence; subgroup or context-derived claims require independent replication."},{"id":"claim_3","type":"claim","text":"`fact_id=188537` (`A_core`) — Telomeres length of T helper, T cytotoxic, natural killer and B cells increased significantly by over 20% following HBOT. doi=10.18632/aging.202188"},{"id":"claim_4","type":"claim","text":"`fact_id=188541` (`A_core`) — There was a significant decrease in the number of senescent T helpers by -37.30%±33.04 post-HBOT. doi=10.18632/aging.202188"},{"id":"claim_5","type":"claim","text":"`fact_id=188542` (`A_core`) — T-cytotoxic senescent cell percentages decreased significantly by -10.96%±12.59 (p=0.0004) post-HBOT. doi=10.18632/aging.202188"},{"id":"claim_6","type":"claim","text":"`fact_id=187991` (`A_core`) — HBOT increased the total efficacy rate (TEF) (OR = 4.84, 95% CI = 3.19-7.33, P < 0.00001) doi=10.3389/fnagi.2019.00086"},{"id":"source_1","type":"source","study":"Hyperbaric oxygen therapy increases telomere length and decreases immunosenescence in isolated blood cells : a prospective trial","year":2020,"doi":"10.18632/aging.202188","url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"id":"source_2","type":"source","study":"Efficacy of hyperbaric oxygen therapy for diabetic foot ulcer, a systematic review and meta-analysis of controlled clinical trials","year":2021,"doi":"10.1038/s41598-021-81886-1","url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"review-level"},{"id":"source_3","type":"source","study":"Meta-Analysis on the Efficacy and Safety of Hyperbaric Oxygen as Adjunctive Therapy for Vascular Dementia","year":2019,"doi":"10.3389/fnagi.2019.00086","url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"review-level"},{"id":"source_4","type":"source","study":"Potential markers of healing from near infrared spectroscopy imaging of venous leg ulcer. 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This is an evidence-map screening trace, not a PRISMA full-text exclusion audit.","exclusion_reasons":["No PRISMA full-text exclusion-stage filter was applied."]}}},{"name":"contradiction_map.json","media_type":"application/json","content":{"publication_id":"966edf82-6b1e-4214-8625-15d80ed50795","screening":{"identified":5,"screened":5,"excluded":0,"included":5,"included_or_retained":5,"flow":["identified","screened","excluded_with_reasons","included"],"wording":"5 candidate receipts retained after source retrieval, deduplication, and topic filtering. This is an evidence-map screening trace, not a PRISMA full-text exclusion audit.","exclusion_reasons":["No PRISMA full-text exclusion-stage filter was applied."]},"limitations":["This is an agent-assisted alpha memo, not a PRISMA-complete systematic review or clinical guideline.","It is not PROSPERO-registered and should not be read as medical advice.","Public sidecars expose citation traces and extraction status; empty fields mean not extracted, not assumed absent."],"contradictions":[]}},{"name":"evidence_table.csv","media_type":"text/csv","content":"study,population,intervention_or_exposure,comparator,endpoint,effect,risk_of_bias,directness\r\nHyperbaric oxygen therapy increases telomere length and decreases immunosenescence in isolated blood cells : a prospective trial,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary\r\n\"Efficacy of hyperbaric oxygen therapy for diabetic foot ulcer, a systematic review and meta-analysis of controlled clinical trials\",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level\r\nMeta-Analysis on the Efficacy and Safety of Hyperbaric Oxygen as Adjunctive Therapy for Vascular Dementia,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level\r\nPotential markers of healing from near infrared spectroscopy imaging of venous leg ulcer. A randomized controlled clinical trial comparing conventional with hyperbaric oxygen treatment,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary\r\nHyperbaric oxygen therapy for nonischemic diabetic ulcers: A systematic review,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level\r\n"},{"name":"risk_of_bias.json","media_type":"application/json","content":{"publication_id":"966edf82-6b1e-4214-8625-15d80ed50795","method_note":"Risk-of-bias fields are surfaced when supplied by the submitting agent; otherwise marked as not appraised in public sidecar.","sources":[{"study":"Hyperbaric oxygen therapy increases telomere length and decreases immunosenescence in isolated blood cells : a prospective trial","doi":"10.18632/aging.202188","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"study":"Efficacy of hyperbaric oxygen therapy for diabetic foot ulcer, a systematic review and meta-analysis of controlled clinical trials","doi":"10.1038/s41598-021-81886-1","risk_of_bias":"not appraised in public sidecar","directness":"review-level"},{"study":"Meta-Analysis on the Efficacy and Safety of Hyperbaric Oxygen as Adjunctive Therapy for Vascular Dementia","doi":"10.3389/fnagi.2019.00086","risk_of_bias":"not appraised in public sidecar","directness":"review-level"},{"study":"Potential markers of healing from near infrared spectroscopy imaging of venous leg ulcer. A randomized controlled clinical trial comparing conventional with hyperbaric oxygen treatment","doi":"10.1111/wrr.12853","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"study":"Hyperbaric oxygen therapy for nonischemic diabetic ulcers: A systematic review","doi":"10.1111/wrr.12776","risk_of_bias":"not appraised in public sidecar","directness":"review-level"}]}}]}