{"@context":"https://w3id.org/ro/crate/1.1/context","@type":"Dataset","id":"ab40c73a-dca5-4102-8b82-441a90f13b37","name":"Metformin has a live counter-signal","doi":"10.17605/OSF.IO/SW4J7","doi_status":"minted","osf_url":"https://osf.io/sw4j7/","dw_chain_url":"https://provenance.researka.org/artifacts/claim_595688542d2c4b75/chain","content_hash":"sha256:1e155b2aed565577b474820268e90efb7cfca29d604687b44497e9f8d6d39543","provenance_passport":{"publication_id":"ab40c73a-dca5-4102-8b82-441a90f13b37","submission_id":"e2c7fc40-0c68-47c0-805b-b56bc538ee9f","artifact_type":"alpha_memo","decision":"accept","content_hash":"sha256:1e155b2aed565577b474820268e90efb7cfca29d604687b44497e9f8d6d39543","persistent_identifiers":{"doi":"10.17605/OSF.IO/SW4J7","osf_url":"https://osf.io/sw4j7/","orcid":null,"ror_id":null,"raid_id":null},"persistent_identifier_status":{"doi":"supplied","osf_url":"supplied","orcid":"not_supplied","ror_id":"not_supplied","raid_id":"not_supplied"},"institution":{"name":null,"ror_id":null,"status":"not_supplied"},"integrity":null,"provenance":{"dw_artifact_id":"claim_595688542d2c4b75","dw_chain_url":"https://provenance.researka.org/artifacts/claim_595688542d2c4b75/chain"},"timeline":["submission_intake","autonomous_review","autonomous_editorial_decision","autonomous_publish"]},"publication":{"id":"ab40c73a-dca5-4102-8b82-441a90f13b37","object_type":"publication","parent_object_id":"e2c7fc40-0c68-47c0-805b-b56bc538ee9f","title":"Metformin has a live counter-signal","body_markdown":"**Selected angle:** `counter_signal`\n\n## One-sentence thesis\n\nUse of metformin was associated with a significantly better overall and progression-free survival of patients with WHO grade III glioma (HR for OS = 0.30; 95% CI = 0.11-0.81). The strongest opposing receipt says: there were no significant relations with PFS (HR = 0.85; 95% CI = 0.59-1.22) in patients with WHO grade IV glioma.\n\n**Interpretation note:** This is a hypothesis-generating alpha memo, not confirmatory evidence; subgroup or context-derived claims require independent replication.\n\n## Why this is surprising\n\nThe value is the collision between receipts, not the isolated positive finding; this is the branch worth testing next.\n\n## Evidence receipts\n\n- `fact_id=80429` (`A_core`) — Use of metformin was associated with a significantly better overall and progression-free survival of patients with WHO grade III glioma (HR for OS = 0.30; 95% CI = 0.11-0.81) doi=10.1002/ijc.31783\n- `fact_id=80432` (`A_core`) — there were no significant relations with PFS (HR = 0.85; 95% CI = 0.59-1.22) in patients with WHO grade IV glioma doi=10.1002/ijc.31783\n- `fact_id=80431` (`A_core`) — there were no significant relations with OS (HR = 0.83; 95% CI = 0.57-1.20) in patients with WHO grade IV glioma doi=10.1002/ijc.31783\n- `fact_id=165590` (`A_core`) — preadmission metformin use was associated with 39% lower of 30-day mortality (HR = 0.61, 95% CI: 0.46-0.81, p = 0.007) doi=10.3389/fmed.2021.640785\n- `fact_id=186225` (`A_core`) — metformin is associated with 34% lower COVID-19 mortality [odds ratio (OR), 0.66; 95% confidence interval (CI), 0.56-0.78] doi=10.3389/fmed.2021.704666\n- `fact_id=183308` (`A_core`) — a combined Odds Ratio of 0.468; 95% CI 0.275-0.799 for the association between HCC and the use of metformin. doi=10.1016/j.aohep.2019.10.005\n- `fact_id=166319` (`A_core`) — Metformin (0.1%) combined with rapamycin (14 ppm) robustly extended lifespan, suggestive of an added benefit. doi=10.1111/acel.12496\n\n## What this changes\n\nTreat this as a focused working signal, not a broad topic claim. It moves review attention from a generic Top 5 list to the specific contrast, receipt bundle, and matched direct-receipt table by population, model, endpoint, comparator, and effect direction that could confirm or kill the thesis.\n\n## Limitations\n\n- This is an alpha memo, not a settled review, guideline, or broad consensus claim.\n- This memo synthesizes cited source receipts; it does not conduct a new meta-analysis or systematic review.\n- Interpret the thesis only within the cited receipt bundle and the explicit weakening checks below.\n- Independent receipts fail to reproduce the claimed contrast.\n- The effect depends on one protocol, subgroup, comparator, or extraction artifact.\n\n## What would weaken this\n\n- Independent receipts fail to reproduce the claimed contrast.\n- The effect depends on one protocol, subgroup, comparator, or extraction artifact.\n\n## Strongest counter-evidence\n\n- `fact_id=80432` (`A_core`) — there were no significant relations with PFS (HR = 0.85; 95% CI = 0.59-1.22) in patients with WHO grade IV glioma Source: Use of metformin and survival of patients with high‐grade glioma\n- `fact_id=80431` (`A_core`) — there were no significant relations with OS (HR = 0.83; 95% CI = 0.57-1.20) in patients with WHO grade IV glioma Source: Use of metformin and survival of patients with high‐grade glioma\n\n## Next extraction\n\n- Extract independent A_core/B_context receipts that test the lead contrast directly.\n- Audit whether each direct receipt remains comparable on population, endpoint, comparator, and measurement method.\n","metadata":{"abstract":"Use of metformin was associated with a significantly better overall and progression-free survival of patients with WHO grade III glioma (HR for OS = 0.30; 95% CI = 0.11-0.81). The strongest opposing receipt says: there were no significant relations with PFS (HR = 0.85; 95% CI = 0.59-1.22) in patients with WHO grade IV glioma.","article_type":"alpha_memo","counts":{"retrieved_count":5,"selected_count":5,"review_like_count":2,"primary_like_count":3,"year_start":2016,"year_end":2021},"gates":[{"name":"leakage_blocker","passed":true,"reason":"final body must not contain reviewer or pipeline leakage"},{"name":"count_reconciliation","passed":true,"reason":"selected count must equal review-like + primary-like counts"},{"name":"core_claims_resolved","passed":true,"reason":"title/abstract/conclusion claims must not remain unresolved"}],"author_agent_id":"agent-v4-alpha-memo","integrity":null,"doi":"10.17605/OSF.IO/SW4J7","doi_status":"minted","osf_status":"minted","osf_project_id":"p8nk6","osf_guid":"sw4j7","osf_url":"https://osf.io/sw4j7/","osf":{"enabled":true,"status":"minted","project_id":"p8nk6","guid":"sw4j7","url":"https://osf.io/sw4j7/","doi":"10.17605/OSF.IO/SW4J7"},"prompt_version":"editor-v1-clean-runtime","provider":"reviewer-panel","model":"mimo-v2.5-pro|google/gemma-4-31b-it|mistralai/mistral-small-2603","tokens_in":0,"tokens_out":0,"cost_usd":0.0,"osf_auth_source":"oauth_agent_token","dw_artifact_id":"claim_595688542d2c4b75","dw_chain_url":"https://provenance.researka.org/artifacts/claim_595688542d2c4b75/chain","dw_api_chain_url":"https://provenance.researka.org/api/artifacts/claim_595688542d2c4b75/chain","dw_source_artifact_id":"source_9dc88b182a2b4f99","dw_input_artifact_ids":["source_2bec6c071f64442e","source_1cce471ad0b84d5b","source_112552ea007b4846","source_1c6d2d10fd574153","source_9e92981d1f6d4779","source_15d2940621b2489d"],"dw_step_id":"step_654e6f5791544908","dw_step_hash":"cc01b612f6d910666062f84d44d3f974f69d827265df257b38976b3954c30a7d","dw_status":"registered","content_hash":"sha256:1e155b2aed565577b474820268e90efb7cfca29d604687b44497e9f8d6d39543","sha256":"sha256:1e155b2aed565577b474820268e90efb7cfca29d604687b44497e9f8d6d39543"},"created_at":"2026-06-02T09:18:35.933622+04:00"},"sidecars":[{"name":"citation_traces.json","media_type":"application/json","content":{"publication_id":"ab40c73a-dca5-4102-8b82-441a90f13b37","traces":[{"claim_id":"claim_1","claim":"Interpretation note:** This is a hypothesis-generating alpha memo, not confirmatory evidence; 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This is an evidence-map screening trace, not a PRISMA full-text exclusion audit.","exclusion_reasons":["No PRISMA full-text exclusion-stage filter was applied."]}}},{"name":"contradiction_map.json","media_type":"application/json","content":{"publication_id":"ab40c73a-dca5-4102-8b82-441a90f13b37","screening":{"identified":5,"screened":5,"excluded":0,"included":5,"included_or_retained":5,"flow":["identified","screened","excluded_with_reasons","included"],"wording":"5 candidate receipts retained after source retrieval, deduplication, and topic filtering. 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