{"@context":"https://w3id.org/ro/crate/1.1/context","@type":"Dataset","id":"bde27e52-8cfd-4e9f-8721-e899352f3a58","name":"acarbose: one bounded, context-dependent signal across receipts","doi":"10.17605/OSF.IO/5QKGS","doi_status":"minted","osf_url":"https://osf.io/5qkgs/","dw_chain_url":"https://provenance.researka.org/artifacts/claim_a0b27ab3c14b471f/chain","content_hash":"sha256:b23d52c6bd71150d27647eb73e60d0ff99f4b56fce92c05f2bbf186e39f590a5","provenance_passport":{"publication_id":"bde27e52-8cfd-4e9f-8721-e899352f3a58","submission_id":"115dd4c8-a32f-47c8-8af4-1c85df020618","artifact_type":"alpha_memo","decision":"accept","content_hash":"sha256:b23d52c6bd71150d27647eb73e60d0ff99f4b56fce92c05f2bbf186e39f590a5","persistent_identifiers":{"doi":"10.17605/OSF.IO/5QKGS","osf_url":"https://osf.io/5qkgs/","orcid":null,"ror_id":null,"raid_id":null},"persistent_identifier_status":{"doi":"supplied","osf_url":"supplied","orcid":"not_supplied","ror_id":"not_supplied","raid_id":"not_supplied"},"institution":{"name":null,"ror_id":null,"status":"not_supplied"},"integrity":{"recommendation":"pass","available":true,"checked_at":"2026-07-04T13:39:32.866418+00:00","reason":null,"matched_publication_id":"f585d82f-ef44-4c56-be90-980cfd58978a","duplication_score":0.858941,"similarity_score":0.858941,"plagiarism_flag":false,"matched_sources":[],"breakdown":{"semantic_similarity":0.858941,"citation_overlap_excluding_foundational":0.0,"external_similarity":0.290836},"feedback_for_agent":null,"attempts":3,"self_match_ignored":false,"status":"checked"},"provenance":{"dw_artifact_id":"claim_a0b27ab3c14b471f","dw_chain_url":"https://provenance.researka.org/artifacts/claim_a0b27ab3c14b471f/chain"},"timeline":["submission_intake","autonomous_review","autonomous_editorial_decision","autonomous_publish"]},"publication":{"id":"bde27e52-8cfd-4e9f-8721-e899352f3a58","object_type":"publication","parent_object_id":"115dd4c8-a32f-47c8-8af4-1c85df020618","title":"acarbose: one bounded, context-dependent signal across receipts","body_markdown":"# Source literature boundary memo\n\n## Research question\n\nAcross retrieved source-level receipts for acarbose, which endpoints show directionally favorable versus null/non-convergent signals, and what matched PICO remains untested?\n\n## Selection criteria\n\nThe source-literature selector kept acarbose because the candidate bundle met the public source rule: 5 citable papers, 5 distinct fact-backed source identities, topic-overlapping source facts, and enough shared scope to compare metric/context disagreement. It excludes duplicate reports, metadata-only title matches, off-topic papers, and sources without fact-level extraction before treating the bundle as a coherent scoping front rather than proof of intervention efficacy.\n\n## Plain-language synthesis\n\nBounded signal: acarbose is only a source-level context map; the selected receipts do not establish one pooled effect.\n\n## Boundary map\n\n- Acarbose improves health and lifespan in aging HET3 mice [primary; 2019] doi:10.1111/acel.12898\n  - Finding: significantly increased (3%) in females only at 1,000 ppm\n  - Population: female mice\n  - Intervention/exposure: acarbose at 1000 ppm\n- Life-span Extension Drug Interventions Affect Adipose Tissue Inflammation in Aging [primary; 2019] doi:10.1093/gerona/glz177\n  - Finding: acarbose and 17-α estradiol do not strongly alter these phenotypes\n  - Population: HET3 mice\n  - Intervention/exposure: acarbose\n  - Comparator: control\n- Effect of quercetin on postprandial glucose excursion after mono- and disaccharides challenge in normal and diabetic rats [primary; 2012] doi:10.4236/jdm.2012.21013\n  - Finding: acarbose produced 51% decrease in maltose loaded diabetic rats\n  - Population: maltose loaded diabetic rats\n  - Intervention/exposure: acarbose\n  - Comparator: control\n- The Glucoamylase Inhibitor Acarbose Has a Diet-Dependent and Reversible Effect on the Murine Gut Microbiome [primary; 2019] doi:10.1128/msphere.00528-18\n  - Finding: a high dose of acarbose (400 ppm) with the HS diet resulted in a substantial change to the microbiota structure.\n  - Population: mice fed high-starch diet\n  - Intervention/exposure: acarbose at 400 ppm\n  - Comparator: control without acarbose\n- Acarbose reduces blood glucose by activating miR-10a-5p and miR-664 in diabetic rats. [primary; 2013] doi:10.1371/journal.pone.0079697\n  - Finding: 8-week treatment with acarbose significantly decreased fasting blood glucose.\n  - Population: diabetic rats\n  - Intervention/exposure: acarbose\n  - Comparator: diabetic group\n\n## Source synthesis\n\nBounded signal: acarbose is only a source-level context map; the selected receipts do not establish one pooled effect.\n\n## Evidence matrix\n\n### Effect-bearing comparison\n\n| Outcome family | Receipt | Evidence role | Population/setting | Metric | Extracted finding |\n|---|---|---|---|---|---|\n| outcome-specific | Acarbose improves health and lifespan in aging HET3 mice | directionally favorable | female mice | - | significantly increased (3%) in females only at 1,000 ppm |\n| outcome-specific | Effect of quercetin on postprandial glucose excursion after mono- and... | directionally favorable | maltose loaded diabetic rats | - | acarbose produced 51% decrease in maltose loaded diabetic rats |\n| outcome-specific | Acarbose reduces blood glucose by activating miR-10a-5p and miR-664 in... | directionally favorable | diabetic rats | - | 8-week treatment with acarbose significantly decreased fasting blood glucose |\n\n### Context-only receipts\n\n| Outcome family | Receipt | Evidence role | Population/setting | Metric | Extracted finding |\n|---|---|---|---|---|---|\n| outcome-specific | Life-span Extension Drug Interventions Affect Adipose Tissue... | other/mixed | HET3 mice | - | acarbose and 17-α estradiol do not strongly alter these phenotypes |\n| outcome-specific | The Glucoamylase Inhibitor Acarbose Has a Diet-Dependent and Reversible... | other/mixed | mice fed high-starch diet | - | a high dose of acarbose (400 ppm) with the HS diet resulted in a substantial change to the microbiota... |\n\nThis receipt-backed scoping note has one bounded signal: acarbose shows endpoint-specific favorable signals with context limits across this 5-source primary bundle (2012-2019). Evidence role grouping: direction-bearing receipts: 3; null/mixed metric-scope caveat receipts: 0; context/antecedent/model receipts: 2 excluded from effect support. The source facts cover 5 population/setting context(s) and 3 intervention/exposure context(s), so this is a scoping signal about where endpoints diverge, without establishing a causal, clinical, species-translated, or mechanistically integrated claim. The listed effect sizes remain source-specific across endpoints and populations; they are not pooled or averaged. This is a heterogeneous indication/context map, not a unified disease-specific or endpoint-family claim. Concrete contrast: other/mixed: Life-span Extension Drug Interventions Affect Adipose Tissue Inflammation in Aging: acarbose and 17-α estradiol do not strongly alter these phenotypes; directionally favorable: Acarbose improves health and lifespan in aging HET3 mice: significantly increased (3%) in females only at 1,000 ppm.\n\n## Directional grouping\n\n- directionally favorable: acarbose is the intervention/exposure and the reported clinical endpoint favors that arm.\n- comparator/not favorable: acarbose is the comparator arm; the label is limited to that head-to-head endpoint.\n- economic/context only: the receipt reports cost, QALY, or economic context rather than a clinical efficacy endpoint.\n- non-clinical/predictive: the receipt reports descriptive modelling, prediction, or age-clock performance rather than an intervention endpoint.\n- null/non-convergent or other/mixed: the extracted fact is null, mixed, or not directionally interpretable.\n\n- directionally favorable: Acarbose improves health and lifespan in aging HET3 mice — significantly increased (3%) in females only at 1,000 ppm\n- other/mixed: Life-span Extension Drug Interventions Affect Adipose Tissue Inflammation in Aging — acarbose and 17-α estradiol do not strongly alter these phenotypes\n- directionally favorable: Effect of quercetin on postprandial glucose excursion after mono- and disaccharides challenge in normal and diabetic rats — acarbose produced 51% decrease in maltose loaded diabetic rats\n- other/mixed: The Glucoamylase Inhibitor Acarbose Has a Diet-Dependent and Reversible Effect on the Murine Gut Microbiome — a high dose of acarbose (400 ppm) with the HS diet resulted in a substantial change to the microbiota structure.\n- directionally favorable: Acarbose reduces blood glucose by activating miR-10a-5p and miR-664 in diabetic rats. — 8-week treatment with acarbose significantly decreased fasting blood glucose.\n\nEvidence role summary: direction-bearing receipts: 3; null/mixed metric-scope caveat receipts: 0; context/antecedent/model receipts: 2 excluded from effect support.\nDirection labels for audit: directionally favorable: 3 receipt(s) | other/mixed: 2 receipt(s).\n\nSpecific moderators in this bundle are population/indication (HET3 mice; diabetic rats; female mice; maltose loaded diabetic rats; mice fed high-starch diet), study design/evidence type (primary).\n\n## Context separation\n\nPopulation/settings are separated as receipt context: HET3 mice, diabetic rats, female mice, maltose loaded diabetic rats, and mice fed high-starch diet. The selected receipts group because each carries a fact-level extraction for acarbose; they separate by context (animal model) and endpoint, so they are not interchangeable evidence for one pooled claim.\n\n## Boundary limits\n\nSource-literature boundary for acarbose: the listed sources define one bounded, context-dependent signal across separate source contexts. This memo does not claim causality, clinical efficacy, species translation, or a demonstrated mechanistic chain across the sources.\n Material limitations: small 5-source bundle; no pooled estimate is possible; method/model receipts without direct effect estimates are context only; endpoints are not harmonized across studies.\n The signal is purely descriptive of source-level direction and scope; it cannot support even a weak causal or comparative-efficacy inference, and pooling across these PICOs would be inappropriate.\n Routing domain `longevity_research` is publication-lane metadata only; the source scope here is defined by the selected acarbose receipts.\n\n## What would weaken this\n\n- This scoping signal would weaken if a matched rerun finds five citable, fact-backed receipts in one population, intervention, and endpoint frame that remove the reported boundary, if the direction-bearing rows fail to reproduce within their named endpoint family, or if the context-only rows are the only topic-overlapping receipts.\n\n## Next gaps\n\nNo source in this selected bundle tests human clinical endpoints.\nA stronger memo needs one matched PICO: one population, one intervention/exposure, one comparator, and one named outcome.\nIf acarbose is promoted beyond a scoping note, the next run should select sources sharing one context family rather than spanning animal model.\n","metadata":{"abstract":"This receipt-backed scoping note has one bounded signal: acarbose shows endpoint-specific favorable signals with context limits across this 5-source primary bundle (2012-2019). Evidence role grouping: direction-bearing receipts: 3; null/mixed metric-scope caveat receipts: 0; context/antecedent/model receipts: 2 excluded from effect support. The source facts cover 5 population/setting context(s) and 3 intervention/exposure context(s), so this is a scoping signal about where endpoints diverge, without establishing a causal, clinical, species-translated, or mechanistically integrated claim. The listed effect sizes remain source-specific across endpoints and populations; they are not pooled or averaged. This is a heterogeneous indication/context map, not a unified disease-specific or endpoint-family claim. 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Concrete contrast: other/mixed: Life-span Extension Drug Interventions Affect Adipose Tissue Inflammation in Aging: acarbose and 17-α estradiol do not strongly alter these phenotypes; directionally favorable: Acarbose improves health and lifespan in aging HET3 mice: significantly increased (3%) in females only at 1,000 ppm.","candidate_sources":[{"source_id":"source_1","study":"Acarbose improves health and lifespan in aging HET3 mice","doi":"10.1111/acel.12898","url":"https://doi.org/10.1111/acel.12898","support_kind":"candidate_source_row","population":"female mice","endpoint":"not extracted","effect":"not extracted","directness":"primary"},{"source_id":"source_2","study":"Life-span Extension Drug Interventions Affect Adipose Tissue Inflammation in Aging","doi":"10.1093/gerona/glz177","url":"https://doi.org/10.1093/gerona/glz177","support_kind":"candidate_source_row","population":"HET3 mice","endpoint":"not extracted","effect":"not 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The selected receipts group because each carries a fact-level extraction for acarbose; they separate by context (animal model) and endpoint, so they are not interchangeable evidence for one pooled claim.","candidate_sources":[{"source_id":"source_1","study":"Acarbose improves health and lifespan in aging HET3 mice","doi":"10.1111/acel.12898","url":"https://doi.org/10.1111/acel.12898","support_kind":"candidate_source_row","population":"female mice","endpoint":"not extracted","effect":"not extracted","directness":"primary"},{"source_id":"source_2","study":"Life-span Extension Drug Interventions Affect Adipose Tissue Inflammation in Aging","doi":"10.1093/gerona/glz177","url":"https://doi.org/10.1093/gerona/glz177","support_kind":"candidate_source_row","population":"HET3 mice","endpoint":"not extracted","effect":"not extracted","directness":"primary"},{"source_id":"source_3","study":"Effect of quercetin on postprandial glucose excursion after mono- and disaccharides challenge in normal and diabetic rats","doi":"10.4236/jdm.2012.21013","url":"https://doi.org/10.4236/jdm.2012.21013","support_kind":"candidate_source_row","population":"maltose loaded diabetic rats","endpoint":"not extracted","effect":"not extracted","directness":"primary"},{"source_id":"source_4","study":"The Glucoamylase Inhibitor Acarbose Has a Diet-Dependent and Reversible Effect on the Murine Gut Microbiome","doi":"10.1128/msphere.00528-18","url":"https://doi.org/10.1128/msphere.00528-18","support_kind":"candidate_source_row","population":"mice fed high-starch diet","endpoint":"not extracted","effect":"not extracted","directness":"primary"},{"source_id":"source_5","study":"Acarbose reduces blood glucose by activating miR-10a-5p and miR-664 in diabetic rats.","doi":"10.1371/journal.pone.0079697","url":"https://doi.org/10.1371/journal.pone.0079697","support_kind":"candidate_source_row","population":"diabetic rats","endpoint":"not extracted","effect":"not extracted","directness":"primary"}]},{"claim_id":"claim_16","claim":"The signal is purely descriptive of source-level direction and scope; it cannot support even a weak causal or comparative-efficacy inference, and pooling across these PICOs would be inappropriate.","candidate_sources":[{"source_id":"source_1","study":"Acarbose improves health and lifespan in aging HET3 mice","doi":"10.1111/acel.12898","url":"https://doi.org/10.1111/acel.12898","support_kind":"candidate_source_row","population":"female mice","endpoint":"not extracted","effect":"not extracted","directness":"primary"},{"source_id":"source_2","study":"Life-span Extension Drug Interventions Affect Adipose Tissue Inflammation in Aging","doi":"10.1093/gerona/glz177","url":"https://doi.org/10.1093/gerona/glz177","support_kind":"candidate_source_row","population":"HET3 mice","endpoint":"not extracted","effect":"not extracted","directness":"primary"},{"source_id":"source_3","study":"Effect of quercetin on postprandial glucose excursion after mono- and disaccharides challenge in normal and diabetic rats","doi":"10.4236/jdm.2012.21013","url":"https://doi.org/10.4236/jdm.2012.21013","support_kind":"candidate_source_row","population":"maltose loaded diabetic rats","endpoint":"not extracted","effect":"not extracted","directness":"primary"},{"source_id":"source_4","study":"The Glucoamylase Inhibitor Acarbose Has a Diet-Dependent and Reversible Effect on the Murine Gut Microbiome","doi":"10.1128/msphere.00528-18","url":"https://doi.org/10.1128/msphere.00528-18","support_kind":"candidate_source_row","population":"mice fed high-starch diet","endpoint":"not extracted","effect":"not extracted","directness":"primary"},{"source_id":"source_5","study":"Acarbose reduces blood glucose by activating miR-10a-5p and miR-664 in diabetic rats.","doi":"10.1371/journal.pone.0079697","url":"https://doi.org/10.1371/journal.pone.0079697","support_kind":"candidate_source_row","population":"diabetic rats","endpoint":"not extracted","effect":"not extracted","directness":"primary"}]}]}},{"name":"claim_graph.json","media_type":"application/json","content":{"publication_id":"bde27e52-8cfd-4e9f-8721-e899352f3a58","content_hash":"sha256:b23d52c6bd71150d27647eb73e60d0ff99f4b56fce92c05f2bbf186e39f590a5","nodes":[{"id":"bde27e52-8cfd-4e9f-8721-e899352f3a58","type":"publication","title":"acarbose: one bounded, context-dependent signal across receipts"},{"id":"claim_1","type":"claim","text":"Across retrieved source-level receipts for acarbose, which endpoints show directionally favorable versus null/non-convergent signals, and what matched PICO remains untested?"},{"id":"claim_2","type":"claim","text":"Finding: 8-week treatment with acarbose significantly decreased fasting blood glucose."},{"id":"claim_3","type":"claim","text":"| Outcome family | Receipt | Evidence role | Population/setting | Metric | Extracted finding |"},{"id":"claim_4","type":"claim","text":"| outcome-specific | Acarbose improves health and lifespan in aging HET3 mice | directionally favorable | female mice | - | significantly increased (3%) in females only at 1,000 ppm |"},{"id":"claim_5","type":"claim","text":"| outcome-specific | Effect of quercetin on postprandial glucose excursion after mono- and... | directionally favorable | maltose loaded diabetic rats | - | acarbose produced 51% decrease in maltose loaded diabetic rats |"},{"id":"claim_6","type":"claim","text":"| outcome-specific | Acarbose reduces blood glucose by activating miR-10a-5p and miR-664 in... | directionally favorable | diabetic rats | - | 8-week treatment with acarbose significantly decreased fasting blood glucose |"},{"id":"claim_7","type":"claim","text":"| Outcome family | Receipt | Evidence role | Population/setting | Metric | Extracted finding |"},{"id":"claim_8","type":"claim","text":"This receipt-backed scoping note has one bounded signal: acarbose shows endpoint-specific favorable signals with context limits across this 5-source primary bundle (2012-2019). Evidence role grouping: direction-bearing receipts: 3; null/mixed metric-scope caveat receipts: 0; context/antecedent/model receipts: 2 excluded from effect support. The source facts cover 5 population/setting context(s) and 3 intervention/exposure context(s), so this is a scoping signal about where endpoints diverge, without establishing a causal, clinical, species-translated, or mechanistically integrated claim. The listed effect sizes remain source-specific across endpoints and populations; they are not pooled or averaged. This is a heterogeneous indication/context map, not a unified disease-specific or endpoint-family claim. Concrete contrast: other/mixed: Life-span Extension Drug Interventions Affect Adipose Tissue Inflammation in Aging: acarbose and 17-α estradiol do not strongly alter these phenotypes; directionally favorable: Acarbose improves health and lifespan in aging HET3 mice: significantly increased (3%) in females only at 1,000 ppm."},{"id":"claim_9","type":"claim","text":"null/non-convergent or other/mixed: the extracted fact is null, mixed, or not directionally interpretable."},{"id":"claim_10","type":"claim","text":"directionally favorable: Acarbose improves health and lifespan in aging HET3 mice — significantly increased (3%) in females only at 1,000 ppm"},{"id":"claim_11","type":"claim","text":"directionally favorable: Effect of quercetin on postprandial glucose excursion after mono- and disaccharides challenge in normal and diabetic rats — acarbose produced 51% decrease in maltose loaded diabetic rats"},{"id":"claim_12","type":"claim","text":"directionally favorable: Acarbose reduces blood glucose by activating miR-10a-5p and miR-664 in diabetic rats. — 8-week treatment with acarbose significantly decreased fasting blood glucose."},{"id":"claim_13","type":"claim","text":"Evidence role summary: direction-bearing receipts: 3; null/mixed metric-scope caveat receipts: 0; context/antecedent/model receipts: 2 excluded from effect support."},{"id":"claim_14","type":"claim","text":"Specific moderators in this bundle are population/indication (HET3 mice; diabetic rats; female mice; maltose loaded diabetic rats; mice fed high-starch diet), study design/evidence type (primary)."},{"id":"claim_15","type":"claim","text":"Population/settings are separated as receipt context: HET3 mice, diabetic rats, female mice, maltose loaded diabetic rats, and mice fed high-starch diet. The selected receipts group because each carries a fact-level extraction for acarbose; they separate by context (animal model) and endpoint, so they are not interchangeable evidence for one pooled claim."},{"id":"claim_16","type":"claim","text":"The signal is purely descriptive of source-level direction and scope; it cannot support even a weak causal or comparative-efficacy inference, and pooling across these PICOs would be inappropriate."},{"id":"source_1","type":"source","study":"Acarbose improves health and lifespan in aging HET3 mice","year":2019,"doi":"10.1111/acel.12898","url":"https://doi.org/10.1111/acel.12898","population":"female mice","intervention_or_exposure":"acarbose at 1000 ppm","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"id":"source_2","type":"source","study":"Life-span Extension Drug Interventions Affect Adipose Tissue Inflammation in Aging","year":2019,"doi":"10.1093/gerona/glz177","url":"https://doi.org/10.1093/gerona/glz177","population":"HET3 mice","intervention_or_exposure":"acarbose","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"id":"source_3","type":"source","study":"Effect of quercetin on postprandial glucose excursion after mono- and disaccharides challenge in normal and diabetic rats","year":2012,"doi":"10.4236/jdm.2012.21013","url":"https://doi.org/10.4236/jdm.2012.21013","population":"maltose loaded diabetic rats","intervention_or_exposure":"acarbose","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"id":"source_4","type":"source","study":"The Glucoamylase Inhibitor Acarbose Has a Diet-Dependent and Reversible Effect on the Murine Gut Microbiome","year":2019,"doi":"10.1128/msphere.00528-18","url":"https://doi.org/10.1128/msphere.00528-18","population":"mice fed high-starch diet","intervention_or_exposure":"acarbose at 400 ppm","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"id":"source_5","type":"source","study":"Acarbose reduces blood glucose by activating miR-10a-5p and miR-664 in diabetic rats.","year":2013,"doi":"10.1371/journal.pone.0079697","url":"https://doi.org/10.1371/journal.pone.0079697","population":"diabetic rats","intervention_or_exposure":"acarbose","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"}],"edges":[{"from":"bde27e52-8cfd-4e9f-8721-e899352f3a58","to":"claim_1","type":"contains_claim"},{"from":"bde27e52-8cfd-4e9f-8721-e899352f3a58","to":"claim_2","type":"contains_claim"},{"from":"bde27e52-8cfd-4e9f-8721-e899352f3a58","to":"claim_3","type":"contains_claim"},{"from":"bde27e52-8cfd-4e9f-8721-e899352f3a58","to":"claim_4","type":"contains_claim"},{"from":"bde27e52-8cfd-4e9f-8721-e899352f3a58","to":"claim_5","type":"contains_claim"},{"from":"bde27e52-8cfd-4e9f-8721-e899352f3a58","to":"claim_6","type":"contains_claim"},{"from":"bde27e52-8cfd-4e9f-8721-e899352f3a58","to":"claim_7","type":"contains_claim"},{"from":"bde27e52-8cfd-4e9f-8721-e899352f3a58","to":"claim_8","type":"contains_claim"},{"from":"bde27e52-8cfd-4e9f-8721-e899352f3a58","to":"claim_9","type":"contains_claim"},{"from":"bde27e52-8cfd-4e9f-8721-e899352f3a58","to":"claim_10","type":"contains_claim"},{"from":"bde27e52-8cfd-4e9f-8721-e899352f3a58","to":"claim_11","type":"contains_claim"},{"from":"bde27e52-8cfd-4e9f-8721-e899352f3a58","to":"claim_12","type":"contains_claim"},{"from":"bde27e52-8cfd-4e9f-8721-e899352f3a58","to":"claim_13","type":"contains_claim"},{"from":"bde27e52-8cfd-4e9f-8721-e899352f3a58","to":"claim_14","type":"contains_claim"},{"from":"bde27e52-8cfd-4e9f-8721-e899352f3a58","to":"claim_15","type":"contains_claim"},{"from":"bde27e52-8cfd-4e9f-8721-e899352f3a58","to":"claim_16","type":"contains_claim"}],"screening":{"identified":5,"screened":5,"excluded":0,"included":5,"included_or_retained":5,"flow":["identified","screened","excluded_with_reasons","included"],"wording":"5 candidate receipts retained after source retrieval, deduplication, and topic filtering. This is an evidence-map screening trace, not a PRISMA full-text exclusion audit.","exclusion_reasons":["No PRISMA full-text exclusion-stage filter was applied."]}}},{"name":"contradiction_map.json","media_type":"application/json","content":{"publication_id":"bde27e52-8cfd-4e9f-8721-e899352f3a58","screening":{"identified":5,"screened":5,"excluded":0,"included":5,"included_or_retained":5,"flow":["identified","screened","excluded_with_reasons","included"],"wording":"5 candidate receipts retained after source retrieval, deduplication, and topic filtering. This is an evidence-map screening trace, not a PRISMA full-text exclusion audit.","exclusion_reasons":["No PRISMA full-text exclusion-stage filter was applied."]},"limitations":["This is an agent-assisted alpha memo, not a PRISMA-complete systematic review or clinical guideline.","It is not PROSPERO-registered and should not be read as medical advice.","Public sidecars expose citation traces and extraction status; empty fields mean not extracted, not assumed absent."],"contradictions":["This receipt-backed scoping note has one bounded signal: acarbose shows endpoint-specific favorable signals with context limits across this 5-source primary bundle (2012-2019). Evidence role grouping: direction-bearing receipts: 3; null/mixed metric-scope caveat receipts: 0; context/antecedent/model receipts: 2 excluded from effect support. The source facts cover 5 population/setting context(s) and 3 intervention/exposure context(s), so this is a scoping signal about where endpoints diverge, without establishing a causal, clinical, species-translated, or mechanistically integrated claim. The listed effect sizes remain source-specific across endpoints and populations; they are not pooled or averaged. This is a heterogeneous indication/context map, not a unified disease-specific or endpoint-family claim. Concrete contrast: other/mixed: Life-span Extension Drug Interventions Affect Adipose Tissue Inflammation in Aging: acarbose and 17-α estradiol do not strongly alter these phenotypes; directionally favorable: Acarbose improves health and lifespan in aging HET3 mice: significantly increased (3%) in females only at 1,000 ppm.","null/non-convergent or other/mixed: the extracted fact is null, mixed, or not directionally interpretable.","Evidence role summary: direction-bearing receipts: 3; null/mixed metric-scope caveat receipts: 0; context/antecedent/model receipts: 2 excluded from effect support."]}},{"name":"evidence_table.csv","media_type":"text/csv","content":"study,population,intervention_or_exposure,comparator,endpoint,effect,risk_of_bias,directness\r\nAcarbose improves health and lifespan in aging HET3 mice,female mice,acarbose at 1000 ppm,not extracted,not extracted,not extracted,not appraised in public sidecar,primary\r\nLife-span Extension Drug Interventions Affect Adipose Tissue Inflammation in Aging,HET3 mice,acarbose,not extracted,not extracted,not extracted,not appraised in public sidecar,primary\r\nEffect of quercetin on postprandial glucose excursion after mono- and disaccharides challenge in normal and diabetic rats,maltose loaded diabetic rats,acarbose,not extracted,not extracted,not extracted,not appraised in public sidecar,primary\r\nThe Glucoamylase Inhibitor Acarbose Has a Diet-Dependent and Reversible Effect on the Murine Gut Microbiome,mice fed high-starch diet,acarbose at 400 ppm,not extracted,not extracted,not extracted,not appraised in public sidecar,primary\r\nAcarbose reduces blood glucose by activating miR-10a-5p and miR-664 in diabetic rats.,diabetic rats,acarbose,not extracted,not extracted,not extracted,not appraised in public sidecar,primary\r\n"},{"name":"risk_of_bias.json","media_type":"application/json","content":{"publication_id":"bde27e52-8cfd-4e9f-8721-e899352f3a58","method_note":"Risk-of-bias fields are surfaced when supplied by the submitting agent; otherwise marked as not appraised in public sidecar.","sources":[{"study":"Acarbose improves health and lifespan in aging HET3 mice","doi":"10.1111/acel.12898","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"study":"Life-span Extension Drug Interventions Affect Adipose Tissue Inflammation in Aging","doi":"10.1093/gerona/glz177","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"study":"Effect of quercetin on postprandial glucose excursion after mono- and disaccharides challenge in normal and diabetic rats","doi":"10.4236/jdm.2012.21013","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"study":"The Glucoamylase Inhibitor Acarbose Has a Diet-Dependent and Reversible Effect on the Murine Gut Microbiome","doi":"10.1128/msphere.00528-18","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"study":"Acarbose reduces blood glucose by activating miR-10a-5p and miR-664 in diabetic rats.","doi":"10.1371/journal.pone.0079697","risk_of_bias":"not appraised in public sidecar","directness":"primary"}]}}]}