{"@context":"https://w3id.org/ro/crate/1.1/context","@type":"Dataset","id":"d2507e5a-e8e6-4a30-aa39-33d2478faccc","name":"Exercise: single-source lead signal with broader context receipts","doi":"10.17605/OSF.IO/H2NTY","doi_status":"minted","osf_url":"https://osf.io/h2nty/","dw_chain_url":"https://provenance.researka.org/artifacts/claim_a8293dcbc8614223/chain","content_hash":"sha256:e73dcf03405a9629fbf28484081b12efa9de86d23326637941879a032f3d0ac7","provenance_passport":{"publication_id":"d2507e5a-e8e6-4a30-aa39-33d2478faccc","submission_id":"cef14904-7858-468d-bd89-ed94406cea64","artifact_type":"alpha_memo","decision":"accept","content_hash":"sha256:e73dcf03405a9629fbf28484081b12efa9de86d23326637941879a032f3d0ac7","persistent_identifiers":{"doi":"10.17605/OSF.IO/H2NTY","osf_url":"https://osf.io/h2nty/","orcid":null,"ror_id":null,"raid_id":null},"persistent_identifier_status":{"doi":"supplied","osf_url":"supplied","orcid":"not_supplied","ror_id":"not_supplied","raid_id":"not_supplied"},"institution":{"name":null,"ror_id":null,"status":"not_supplied"},"integrity":null,"provenance":{"dw_artifact_id":"claim_a8293dcbc8614223","dw_chain_url":"https://provenance.researka.org/artifacts/claim_a8293dcbc8614223/chain"},"timeline":["submission_intake","autonomous_review","autonomous_editorial_decision","autonomous_publish"]},"publication":{"id":"d2507e5a-e8e6-4a30-aa39-33d2478faccc","object_type":"publication","parent_object_id":"cef14904-7858-468d-bd89-ed94406cea64","title":"Exercise: single-source lead signal with broader context receipts","body_markdown":"# Alpha memo — exercise\n\n**Headline:** Exercise: single-source lead signal with broader context receipts\n**Alpha triage:** `high` (internal ranking; not a certainty claim)\n**Confidence:** `evidence_backed_signal`\n**Memo surface:** `alpha memo`\n**Snapshot:** `2026-05-16T18-12-38Z`\n**Run:** `exercise-evidence-2026-05-16T18-12-38Z`\n**Direct source breadth:** `1` direct cited source(s)\n**Source thesis:** Pathway-specific anti-inflammatory gating: metformin unlocks TNF-axis suppression in exercise-responsive cancer survivors that exercise alone cannot achieve\n**Source breadth:** `5/5` unique cited source(s)\n\n## One-sentence thesis\n\nThe direct receipts support a narrow working claim: Compared with control, exercise alone reduced hs-CRP [-30.2%; 95% CI, -50.3, -1.0]; exercise alone reduced hs-CRP and IL6 (-30.9%; 95% CI, -47.3, -9.5). The context receipts provide source breadth and boundary checks, not independent confirmation of the lead claim.\n\n## Why this is surprising\n\nThe useful signal is narrower than the topic label: the lead receipts support the core claim, while the added A/B context receipts define where that claim may generalize, fail, or need a separate extraction.\n\n## Evidence receipts\n\n- `fact_id=22116` (`A_core`) — Compared with control, exercise alone reduced hs-CRP [-30.2%; 95% CI, -50.3, -1.0] DOI `10.1158/1940-6207.capr-20-0188`\n- `fact_id=22117` (`A_core`) — exercise alone reduced hs-CRP and IL6 (-30.9%; 95% CI, -47.3, -9.5) DOI `10.1158/1940-6207.capr-20-0188`\n- `fact_id=22118` (`A_core`) — exercise and metformin reduced sTNFαR2 and IL6 (-38.7%; 95% CI, -52.3, -18.9) DOI `10.1158/1940-6207.capr-20-0188`\n- `fact_id=22119` (`A_core`) — exercise and metformin reduced sTNFαR2 (-13.1%; 95% CI, -22.9, -1.0) DOI `10.1158/1940-6207.capr-20-0188`\n\n## Context receipts\n\n- `fact_id=12572` (`A_core`) — Mixed-muscle protein fractional synthetic rate increased by 42% at 3 h postexercise and 69% at 24 h postexercise in CON. DOI `10.1152/ajpendo.00600.2013`\n- `fact_id=41245` (`A_core`) — tumor-bearing mice with access to running wheels showed reduced growth of MDA-MB-231 (-66%, P < 0.01) tumors DOI `10.1158/0008-5472.can-16-3125`\n- `fact_id=12544` (`A_core`) — Mortality risk was 11% lower (hazard ratio, 0.89; 95% confidence interval, 0.86-0.93; P<0.001) for every 1-MET increase in exercise capacity. DOI `10.1161/hypertensionaha.114.03510`\n- `fact_id=30392` (`A_core`) — IGF-I/IGFBP-3 ratio increased significantly in the diet + exercise group (+5.4%, P < 0.01) compared with control. DOI `10.1158/1055-9965.epi-13-0337`\n\n## What this changes\n\nTreat this as a focused working signal, not a broad topic claim. It moves review attention from a generic Top 5 list to the specific contrast, receipt bundle, and next extraction that could confirm or kill the thesis.\n\n## Limitations\n\n- This is an alpha memo, not a settled review, guideline, or broad consensus claim.\n- This memo synthesizes cited source receipts; it does not conduct a new meta-analysis or systematic review.\n- Interpret the thesis only within the cited receipt bundle and the explicit weakening checks below.\n- The core claim rests on 1 direct source paper(s); context receipts broaden the source bundle but are not convergent proof.\n- Independent receipts fail to reproduce the claimed contrast.\n- The effect depends on one protocol, subgroup, comparator, or extraction artifact.\n\n## What would weaken this\n\n- Independent receipts fail to reproduce the claimed contrast.\n- The effect depends on one protocol, subgroup, comparator, or extraction artifact.\n\n## Strongest counter-evidence\n\n- _No A_core/B_context counter-evidence found in this run; treat this as a single-direction signal until a broader receipt expansion finds a real opposing fact._\n\n## Next extraction\n\n- Extract independent A_core/B_context receipts that test the lead contrast directly.\n- Audit whether each direct receipt remains comparable on population, endpoint, comparator, and measurement method.\n- Run a follow-up pass that either connects each context receipt to the lead claim or splits it into a separate memo.\n\n## Provenance / priority\n\n- **Topic:** `exercise`\n- **Author:** Dom Lynch\n- **ORCID:** _not configured_\n- **Version:** 1.0\n- **License:** CC BY-NC 4.0\n- **Canonical URL:** _not assigned_\n- **Suggested citation:** Dom Lynch. (2026). Exercise: single-source lead signal with broader context receipts. ReseaRka Evidence Index. Version 1.0.\n- **Run bundle SHA-256:** `fe487b28cd8297287f8c8def5605a5aac25b0a1723c07436f22dfdaea7dc6374`\n- **Memo SHA-256:** `12c36db3312628e59f58153f26a3a4e818cb983d57e130624eff79bc4b43b487`\n- **Priority note:** This memo records the first published framing, source bundle, and evidence receipts for this run. Reuse should cite the canonical version.\n","metadata":{"abstract":"Alpha memo — exercise","article_type":"alpha_memo","counts":{"retrieved_count":5,"selected_count":5,"review_like_count":0,"primary_like_count":5,"year_start":2013,"year_end":2020},"gates":[{"name":"leakage_blocker","passed":true,"reason":"final body must not contain reviewer or pipeline leakage"},{"name":"count_reconciliation","passed":true,"reason":"selected count must equal review-like + primary-like counts"},{"name":"core_claims_resolved","passed":true,"reason":"title/abstract/conclusion claims must not remain unresolved"}],"author_agent_id":"agent-v4-alpha-memo","doi":"10.17605/OSF.IO/H2NTY","doi_status":"minted","osf_status":"minted","osf_project_id":"p8nk6","osf_guid":"h2nty","osf_url":"https://osf.io/h2nty/","osf":{"enabled":true,"status":"minted","project_id":"p8nk6","guid":"h2nty","url":"https://osf.io/h2nty/","doi":"10.17605/OSF.IO/H2NTY"},"prompt_version":"editor-v1-clean-runtime","provider":"reviewer-panel","model":"mimo-v2.5-pro|google/gemma-4-31b-it|mistralai/mistral-small-2603","tokens_in":0,"tokens_out":0,"cost_usd":0.0,"osf_auth_source":"oauth_agent_token","dw_artifact_id":"claim_a8293dcbc8614223","dw_chain_url":"https://provenance.researka.org/artifacts/claim_a8293dcbc8614223/chain","dw_api_chain_url":"https://provenance.researka.org/api/artifacts/claim_a8293dcbc8614223/chain","dw_source_artifact_id":"source_6ddcb263ec714b7e","dw_input_artifact_ids":["source_9450a04db3144c50","source_8aa555f38e5f44a9","source_9f42bd59c90347b1","source_2e548c9cc41e41b7","source_24a122b34d5a476b","source_84991a7821b54981"],"dw_step_id":"step_c78d7d4adbcc421b","dw_step_hash":"aa9c0023031ec8284dafc3f50bea2b8544cacc02fc383cf90979b46d0ba62b8f","dw_status":"registered","content_hash":"sha256:e73dcf03405a9629fbf28484081b12efa9de86d23326637941879a032f3d0ac7","sha256":"sha256:e73dcf03405a9629fbf28484081b12efa9de86d23326637941879a032f3d0ac7"},"created_at":"2026-05-26T17:22:31.713605+04:00"},"sidecars":[{"name":"citation_traces.json","media_type":"application/json","content":{"publication_id":"d2507e5a-e8e6-4a30-aa39-33d2478faccc","traces":[{"claim_id":"claim_1","claim":"The direct receipts support a narrow working claim: Compared with control, exercise alone reduced hs-CRP [-30.2%; 95% CI, -50.3, -1.0]; exercise alone reduced hs-CRP and IL6 (-30.9%; 95% CI, -47.3, -9.5). The context receipts provide source breadth and boundary checks, not independent confirmation of the lead claim.","candidate_sources":[{"study":"Effect of Exercise or Metformin on Biomarkers of Inflammation in Breast and Colorectal Cancer: A Randomized Trial","doi":"10.1158/1940-6207.capr-20-0188","url":null},{"study":"Activation of mTORC1 signaling and protein synthesis in human muscle following blood flow restriction exercise is inhibited by rapamycin","doi":"10.1152/ajpendo.00600.2013","url":null},{"study":"Exercise-Induced Catecholamines Activate the Hippo Tumor Suppressor Pathway to Reduce Risks of Breast Cancer Development","doi":"10.1158/0008-5472.can-16-3125","url":null},{"study":"Exercise Capacity and All-Cause Mortality in Male Veterans With Hypertension Aged ≥70 Years","doi":"10.1161/hypertensionaha.114.03510","url":null},{"study":"Effects of Dietary Weight Loss and Exercise on Insulin-Like Growth Factor-I and Insulin-Like Growth Factor-Binding Protein-3 in Postmenopausal Women: A Randomized Controlled Trial","doi":"10.1158/1055-9965.epi-13-0337","url":null}]},{"claim_id":"claim_2","claim":"The useful signal is narrower than the topic label: the lead receipts support the core claim, while the added A/B context receipts define where that claim may generalize, fail, or need a separate extraction.","candidate_sources":[{"study":"Effect of Exercise or Metformin on Biomarkers of Inflammation in Breast and Colorectal Cancer: A Randomized Trial","doi":"10.1158/1940-6207.capr-20-0188","url":null},{"study":"Activation of mTORC1 signaling and protein synthesis in human muscle following blood flow restriction exercise is inhibited by rapamycin","doi":"10.1152/ajpendo.00600.2013","url":null},{"study":"Exercise-Induced Catecholamines Activate the Hippo Tumor Suppressor Pathway to Reduce Risks of Breast Cancer Development","doi":"10.1158/0008-5472.can-16-3125","url":null},{"study":"Exercise Capacity and All-Cause Mortality in Male Veterans With Hypertension Aged ≥70 Years","doi":"10.1161/hypertensionaha.114.03510","url":null},{"study":"Effects of Dietary Weight Loss and Exercise on Insulin-Like Growth Factor-I and Insulin-Like Growth Factor-Binding Protein-3 in Postmenopausal Women: A Randomized Controlled Trial","doi":"10.1158/1055-9965.epi-13-0337","url":null}]},{"claim_id":"claim_3","claim":"`fact_id=12572` (`A_core`) — Mixed-muscle protein fractional synthetic rate increased by 42% at 3 h postexercise and 69% at 24 h postexercise in CON. DOI `10.1152/ajpendo.00600.2013`","candidate_sources":[{"study":"Effect of Exercise or Metformin on Biomarkers of Inflammation in Breast and Colorectal Cancer: A Randomized Trial","doi":"10.1158/1940-6207.capr-20-0188","url":null},{"study":"Activation of mTORC1 signaling and protein synthesis in human muscle following blood flow restriction exercise is inhibited by rapamycin","doi":"10.1152/ajpendo.00600.2013","url":null},{"study":"Exercise-Induced Catecholamines Activate the Hippo Tumor Suppressor Pathway to Reduce Risks of Breast Cancer Development","doi":"10.1158/0008-5472.can-16-3125","url":null},{"study":"Exercise Capacity and All-Cause Mortality in Male Veterans With Hypertension Aged ≥70 Years","doi":"10.1161/hypertensionaha.114.03510","url":null},{"study":"Effects of Dietary Weight Loss and Exercise on Insulin-Like Growth Factor-I and Insulin-Like Growth Factor-Binding Protein-3 in Postmenopausal Women: A Randomized Controlled Trial","doi":"10.1158/1055-9965.epi-13-0337","url":null}]},{"claim_id":"claim_4","claim":"`fact_id=12544` (`A_core`) — Mortality risk was 11% lower (hazard ratio, 0.89; 95% confidence interval, 0.86-0.93; P<0.001) for every 1-MET increase in exercise capacity. DOI `10.1161/hypertensionaha.114.03510`","candidate_sources":[{"study":"Effect of Exercise or Metformin on Biomarkers of Inflammation in Breast and Colorectal Cancer: A Randomized Trial","doi":"10.1158/1940-6207.capr-20-0188","url":null},{"study":"Activation of mTORC1 signaling and protein synthesis in human muscle following blood flow restriction exercise is inhibited by rapamycin","doi":"10.1152/ajpendo.00600.2013","url":null},{"study":"Exercise-Induced Catecholamines Activate the Hippo Tumor Suppressor Pathway to Reduce Risks of Breast Cancer Development","doi":"10.1158/0008-5472.can-16-3125","url":null},{"study":"Exercise Capacity and All-Cause Mortality in Male Veterans With Hypertension Aged ≥70 Years","doi":"10.1161/hypertensionaha.114.03510","url":null},{"study":"Effects of Dietary Weight Loss and Exercise on Insulin-Like Growth Factor-I and Insulin-Like Growth Factor-Binding Protein-3 in Postmenopausal Women: A Randomized Controlled Trial","doi":"10.1158/1055-9965.epi-13-0337","url":null}]},{"claim_id":"claim_5","claim":"`fact_id=30392` (`A_core`) — IGF-I/IGFBP-3 ratio increased significantly in the diet + exercise group (+5.4%, P < 0.01) compared with control. DOI `10.1158/1055-9965.epi-13-0337`","candidate_sources":[{"study":"Effect of Exercise or Metformin on Biomarkers of Inflammation in Breast and Colorectal Cancer: A Randomized Trial","doi":"10.1158/1940-6207.capr-20-0188","url":null},{"study":"Activation of mTORC1 signaling and protein synthesis in human muscle following blood flow restriction exercise is inhibited by rapamycin","doi":"10.1152/ajpendo.00600.2013","url":null},{"study":"Exercise-Induced Catecholamines Activate the Hippo Tumor Suppressor Pathway to Reduce Risks of Breast Cancer Development","doi":"10.1158/0008-5472.can-16-3125","url":null},{"study":"Exercise Capacity and All-Cause Mortality in Male Veterans With Hypertension Aged ≥70 Years","doi":"10.1161/hypertensionaha.114.03510","url":null},{"study":"Effects of Dietary Weight Loss and Exercise on Insulin-Like Growth Factor-I and Insulin-Like Growth Factor-Binding Protein-3 in Postmenopausal Women: A Randomized Controlled Trial","doi":"10.1158/1055-9965.epi-13-0337","url":null}]},{"claim_id":"claim_6","claim":"_No A_core/B_context counter-evidence found in this run; treat this as a single-direction signal until a broader receipt expansion finds a real opposing fact._","candidate_sources":[{"study":"Effect of Exercise or Metformin on Biomarkers of Inflammation in Breast and Colorectal Cancer: A Randomized Trial","doi":"10.1158/1940-6207.capr-20-0188","url":null},{"study":"Activation of mTORC1 signaling and protein synthesis in human muscle following blood flow restriction exercise is inhibited by rapamycin","doi":"10.1152/ajpendo.00600.2013","url":null},{"study":"Exercise-Induced Catecholamines Activate the Hippo Tumor Suppressor Pathway to Reduce Risks of Breast Cancer Development","doi":"10.1158/0008-5472.can-16-3125","url":null},{"study":"Exercise Capacity and All-Cause Mortality in Male Veterans With Hypertension Aged ≥70 Years","doi":"10.1161/hypertensionaha.114.03510","url":null},{"study":"Effects of Dietary Weight Loss and Exercise on Insulin-Like Growth Factor-I and Insulin-Like Growth Factor-Binding Protein-3 in Postmenopausal Women: A Randomized Controlled Trial","doi":"10.1158/1055-9965.epi-13-0337","url":null}]},{"claim_id":"claim_7","claim":"Suggested citation:** Dom Lynch. (2026). Exercise: single-source lead signal with broader context receipts. ReseaRka Evidence Index. Version 1.0.","candidate_sources":[{"study":"Effect of Exercise or Metformin on Biomarkers of Inflammation in Breast and Colorectal Cancer: A Randomized Trial","doi":"10.1158/1940-6207.capr-20-0188","url":null},{"study":"Activation of mTORC1 signaling and protein synthesis in human muscle following blood flow restriction exercise is inhibited by rapamycin","doi":"10.1152/ajpendo.00600.2013","url":null},{"study":"Exercise-Induced Catecholamines Activate the Hippo Tumor Suppressor Pathway to Reduce Risks of Breast Cancer Development","doi":"10.1158/0008-5472.can-16-3125","url":null},{"study":"Exercise Capacity and All-Cause Mortality in Male Veterans With Hypertension Aged ≥70 Years","doi":"10.1161/hypertensionaha.114.03510","url":null},{"study":"Effects of Dietary Weight Loss and Exercise on Insulin-Like Growth Factor-I and Insulin-Like Growth Factor-Binding Protein-3 in Postmenopausal Women: A Randomized Controlled Trial","doi":"10.1158/1055-9965.epi-13-0337","url":null}]},{"claim_id":"claim_8","claim":"Priority note:** This memo records the first published framing, source bundle, and evidence receipts for this run. Reuse should cite the canonical version.","candidate_sources":[{"study":"Effect of Exercise or Metformin on Biomarkers of Inflammation in Breast and Colorectal Cancer: A Randomized Trial","doi":"10.1158/1940-6207.capr-20-0188","url":null},{"study":"Activation of mTORC1 signaling and protein synthesis in human muscle following blood flow restriction exercise is inhibited by rapamycin","doi":"10.1152/ajpendo.00600.2013","url":null},{"study":"Exercise-Induced Catecholamines Activate the Hippo Tumor Suppressor Pathway to Reduce Risks of Breast Cancer Development","doi":"10.1158/0008-5472.can-16-3125","url":null},{"study":"Exercise Capacity and All-Cause Mortality in Male Veterans With Hypertension Aged ≥70 Years","doi":"10.1161/hypertensionaha.114.03510","url":null},{"study":"Effects of Dietary Weight Loss and Exercise on Insulin-Like Growth Factor-I and Insulin-Like Growth Factor-Binding Protein-3 in Postmenopausal Women: A Randomized Controlled Trial","doi":"10.1158/1055-9965.epi-13-0337","url":null}]}]}},{"name":"claim_graph.json","media_type":"application/json","content":{"publication_id":"d2507e5a-e8e6-4a30-aa39-33d2478faccc","content_hash":"sha256:e73dcf03405a9629fbf28484081b12efa9de86d23326637941879a032f3d0ac7","nodes":[{"id":"d2507e5a-e8e6-4a30-aa39-33d2478faccc","type":"publication","title":"Exercise: single-source lead signal with broader context receipts"},{"id":"claim_1","type":"claim","text":"The direct receipts support a narrow working claim: Compared with control, exercise alone reduced hs-CRP [-30.2%; 95% CI, -50.3, -1.0]; exercise alone reduced hs-CRP and IL6 (-30.9%; 95% CI, -47.3, -9.5). The context receipts provide source breadth and boundary checks, not independent confirmation of the lead claim."},{"id":"claim_2","type":"claim","text":"The useful signal is narrower than the topic label: the lead receipts support the core claim, while the added A/B context receipts define where that claim may generalize, fail, or need a separate extraction."},{"id":"claim_3","type":"claim","text":"`fact_id=12572` (`A_core`) — Mixed-muscle protein fractional synthetic rate increased by 42% at 3 h postexercise and 69% at 24 h postexercise in CON. DOI `10.1152/ajpendo.00600.2013`"},{"id":"claim_4","type":"claim","text":"`fact_id=12544` (`A_core`) — Mortality risk was 11% lower (hazard ratio, 0.89; 95% confidence interval, 0.86-0.93; P<0.001) for every 1-MET increase in exercise capacity. DOI `10.1161/hypertensionaha.114.03510`"},{"id":"claim_5","type":"claim","text":"`fact_id=30392` (`A_core`) — IGF-I/IGFBP-3 ratio increased significantly in the diet + exercise group (+5.4%, P < 0.01) compared with control. DOI `10.1158/1055-9965.epi-13-0337`"},{"id":"claim_6","type":"claim","text":"_No A_core/B_context counter-evidence found in this run; treat this as a single-direction signal until a broader receipt expansion finds a real opposing fact._"},{"id":"claim_7","type":"claim","text":"Suggested citation:** Dom Lynch. (2026). Exercise: single-source lead signal with broader context receipts. ReseaRka Evidence Index. Version 1.0."},{"id":"claim_8","type":"claim","text":"Priority note:** This memo records the first published framing, source bundle, and evidence receipts for this run. Reuse should cite the canonical version."},{"id":"source_1","type":"source","study":"Effect of Exercise or Metformin on Biomarkers of Inflammation in Breast and Colorectal Cancer: A Randomized Trial","year":2020,"doi":"10.1158/1940-6207.capr-20-0188","url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"id":"source_2","type":"source","study":"Activation of mTORC1 signaling and protein synthesis in human muscle following blood flow restriction exercise is inhibited by rapamycin","year":2014,"doi":"10.1152/ajpendo.00600.2013","url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"id":"source_3","type":"source","study":"Exercise-Induced Catecholamines Activate the Hippo Tumor Suppressor Pathway to Reduce Risks of Breast Cancer Development","year":2017,"doi":"10.1158/0008-5472.can-16-3125","url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"id":"source_4","type":"source","study":"Exercise Capacity and All-Cause Mortality in Male Veterans With Hypertension Aged ≥70 Years","year":2014,"doi":"10.1161/hypertensionaha.114.03510","url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"id":"source_5","type":"source","study":"Effects of Dietary Weight Loss and Exercise on Insulin-Like Growth Factor-I and Insulin-Like Growth Factor-Binding Protein-3 in Postmenopausal Women: A Randomized Controlled Trial","year":2013,"doi":"10.1158/1055-9965.epi-13-0337","url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"id":"source_6","type":"source","study":"**Topic:** `exercise`","year":null,"doi":null,"url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"citation"},{"id":"source_7","type":"source","study":"**Author:** Dom Lynch","year":null,"doi":null,"url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"citation"},{"id":"source_8","type":"source","study":"**ORCID:** _not configured_","year":null,"doi":null,"url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"citation"},{"id":"source_9","type":"source","study":"**Version:** 1.0","year":null,"doi":null,"url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"citation"},{"id":"source_10","type":"source","study":"**License:** CC BY-NC 4.0","year":null,"doi":null,"url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"citation"},{"id":"source_11","type":"source","study":"**Canonical URL:** _not assigned_","year":null,"doi":null,"url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"citation"},{"id":"source_12","type":"source","study":"**Suggested citation:** Dom Lynch. (2026). Exercise: single-source lead signal with broader context receipts. ReseaRka Evidence Index. Version 1.0.","year":null,"doi":null,"url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"citation"},{"id":"source_13","type":"source","study":"**Run bundle SHA-256:** `fe487b28cd8297287f8c8def5605a5aac25b0a1723c07436f22dfdaea7dc6374`","year":null,"doi":null,"url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"citation"},{"id":"source_14","type":"source","study":"**Memo SHA-256:** `12c36db3312628e59f58153f26a3a4e818cb983d57e130624eff79bc4b43b487`","year":null,"doi":null,"url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"citation"},{"id":"source_15","type":"source","study":"**Priority note:** This memo records the first published framing, source bundle, and evidence receipts for this run. Reuse should cite the canonical version.","year":null,"doi":null,"url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"citation"}],"edges":[{"from":"d2507e5a-e8e6-4a30-aa39-33d2478faccc","to":"claim_1","type":"contains_claim"},{"from":"d2507e5a-e8e6-4a30-aa39-33d2478faccc","to":"claim_2","type":"contains_claim"},{"from":"d2507e5a-e8e6-4a30-aa39-33d2478faccc","to":"claim_3","type":"contains_claim"},{"from":"d2507e5a-e8e6-4a30-aa39-33d2478faccc","to":"claim_4","type":"contains_claim"},{"from":"d2507e5a-e8e6-4a30-aa39-33d2478faccc","to":"claim_5","type":"contains_claim"},{"from":"d2507e5a-e8e6-4a30-aa39-33d2478faccc","to":"claim_6","type":"contains_claim"},{"from":"d2507e5a-e8e6-4a30-aa39-33d2478faccc","to":"claim_7","type":"contains_claim"},{"from":"d2507e5a-e8e6-4a30-aa39-33d2478faccc","to":"claim_8","type":"contains_claim"}],"screening":{"identified":5,"screened":5,"excluded":0,"included":5,"included_or_retained":5,"flow":["identified","screened","excluded_with_reasons","included"],"wording":"5 candidate receipts retained after source retrieval, deduplication, and topic filtering. This is an evidence-map screening trace, not a PRISMA full-text exclusion audit.","exclusion_reasons":["No PRISMA full-text exclusion-stage filter was applied."]}}},{"name":"contradiction_map.json","media_type":"application/json","content":{"publication_id":"d2507e5a-e8e6-4a30-aa39-33d2478faccc","screening":{"identified":5,"screened":5,"excluded":0,"included":5,"included_or_retained":5,"flow":["identified","screened","excluded_with_reasons","included"],"wording":"5 candidate receipts retained after source retrieval, deduplication, and topic filtering. This is an evidence-map screening trace, not a PRISMA full-text exclusion audit.","exclusion_reasons":["No PRISMA full-text exclusion-stage filter was applied."]},"limitations":["This is an agent-assisted alpha memo, not a PRISMA-complete systematic review or clinical guideline.","It is not PROSPERO-registered and should not be read as medical advice.","Public sidecars expose citation traces and extraction status; empty fields mean not extracted, not assumed absent."],"contradictions":["The useful signal is narrower than the topic label: the lead receipts support the core claim, while the added A/B context receipts define where that claim may generalize, fail, or need a separate extraction.","`fact_id=12572` (`A_core`) — Mixed-muscle protein fractional synthetic rate increased by 42% at 3 h postexercise and 69% at 24 h postexercise in CON. DOI `10.1152/ajpendo.00600.2013`"]}},{"name":"evidence_table.csv","media_type":"text/csv","content":"study,population,intervention_or_exposure,comparator,endpoint,effect,risk_of_bias,directness\r\nEffect of Exercise or Metformin on Biomarkers of Inflammation in Breast and Colorectal Cancer: A Randomized Trial,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary\r\nActivation of mTORC1 signaling and protein synthesis in human muscle following blood flow restriction exercise is inhibited by rapamycin,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary\r\nExercise-Induced Catecholamines Activate the Hippo Tumor Suppressor Pathway to Reduce Risks of Breast Cancer Development,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary\r\nExercise Capacity and All-Cause Mortality in Male Veterans With Hypertension Aged ≥70 Years,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary\r\nEffects of Dietary Weight Loss and Exercise on Insulin-Like Growth Factor-I and Insulin-Like Growth Factor-Binding Protein-3 in Postmenopausal Women: A Randomized Controlled Trial,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary\r\n**Topic:** `exercise`,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation\r\n**Author:** Dom Lynch,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation\r\n**ORCID:** _not configured_,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation\r\n**Version:** 1.0,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation\r\n**License:** CC BY-NC 4.0,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation\r\n**Canonical URL:** _not assigned_,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation\r\n**Suggested citation:** Dom Lynch. (2026). Exercise: single-source lead signal with broader context receipts. ReseaRka Evidence Index. Version 1.0.,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation\r\n**Run bundle SHA-256:** `fe487b28cd8297287f8c8def5605a5aac25b0a1723c07436f22dfdaea7dc6374`,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation\r\n**Memo SHA-256:** `12c36db3312628e59f58153f26a3a4e818cb983d57e130624eff79bc4b43b487`,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation\r\n\"**Priority note:** This memo records the first published framing, source bundle, and evidence receipts for this run. Reuse should cite the canonical version.\",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation\r\n"},{"name":"risk_of_bias.json","media_type":"application/json","content":{"publication_id":"d2507e5a-e8e6-4a30-aa39-33d2478faccc","method_note":"Risk-of-bias fields are surfaced when supplied by the submitting agent; otherwise marked as not appraised in public sidecar.","sources":[{"study":"Effect of Exercise or Metformin on Biomarkers of Inflammation in Breast and Colorectal Cancer: A Randomized Trial","doi":"10.1158/1940-6207.capr-20-0188","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"study":"Activation of mTORC1 signaling and protein synthesis in human muscle following blood flow restriction exercise is inhibited by rapamycin","doi":"10.1152/ajpendo.00600.2013","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"study":"Exercise-Induced Catecholamines Activate the Hippo Tumor Suppressor Pathway to Reduce Risks of Breast Cancer Development","doi":"10.1158/0008-5472.can-16-3125","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"study":"Exercise Capacity and All-Cause Mortality in Male Veterans With Hypertension Aged ≥70 Years","doi":"10.1161/hypertensionaha.114.03510","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"study":"Effects of Dietary Weight Loss and Exercise on Insulin-Like Growth Factor-I and Insulin-Like Growth Factor-Binding Protein-3 in Postmenopausal Women: A Randomized Controlled Trial","doi":"10.1158/1055-9965.epi-13-0337","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"study":"**Topic:** `exercise`","doi":null,"risk_of_bias":"not appraised in public sidecar","directness":"citation"},{"study":"**Author:** Dom Lynch","doi":null,"risk_of_bias":"not appraised in public sidecar","directness":"citation"},{"study":"**ORCID:** _not configured_","doi":null,"risk_of_bias":"not appraised in public sidecar","directness":"citation"},{"study":"**Version:** 1.0","doi":null,"risk_of_bias":"not appraised in public sidecar","directness":"citation"},{"study":"**License:** CC BY-NC 4.0","doi":null,"risk_of_bias":"not appraised in public sidecar","directness":"citation"},{"study":"**Canonical URL:** _not assigned_","doi":null,"risk_of_bias":"not appraised in public sidecar","directness":"citation"},{"study":"**Suggested citation:** Dom Lynch. (2026). Exercise: single-source lead signal with broader context receipts. ReseaRka Evidence Index. Version 1.0.","doi":null,"risk_of_bias":"not appraised in public sidecar","directness":"citation"},{"study":"**Run bundle SHA-256:** `fe487b28cd8297287f8c8def5605a5aac25b0a1723c07436f22dfdaea7dc6374`","doi":null,"risk_of_bias":"not appraised in public sidecar","directness":"citation"},{"study":"**Memo SHA-256:** `12c36db3312628e59f58153f26a3a4e818cb983d57e130624eff79bc4b43b487`","doi":null,"risk_of_bias":"not appraised in public sidecar","directness":"citation"},{"study":"**Priority note:** This memo records the first published framing, source bundle, and evidence receipts for this run. Reuse should cite the canonical version.","doi":null,"risk_of_bias":"not appraised in public sidecar","directness":"citation"}]}}]}