{"@context":"https://w3id.org/ro/crate/1.1/context","@type":"Dataset","id":"f271139f-9010-4c8e-bab9-67019d5a231a","name":"Telomere may hinge on a boundary condition","doi":"10.17605/OSF.IO/R3JAK","doi_status":"minted","osf_url":"https://osf.io/r3jak/","dw_chain_url":"https://provenance.researka.org/artifacts/claim_c098c78bc6df4769/chain","content_hash":"sha256:f0bec360f45f86d68ce65b2300624203bb66ebf46badd8406eca36d6414eb436","provenance_passport":{"publication_id":"f271139f-9010-4c8e-bab9-67019d5a231a","submission_id":"0882e7b5-a0dd-401b-95a8-b1bfa288cb6f","artifact_type":"alpha_memo","decision":"accept","content_hash":"sha256:f0bec360f45f86d68ce65b2300624203bb66ebf46badd8406eca36d6414eb436","persistent_identifiers":{"doi":"10.17605/OSF.IO/R3JAK","osf_url":"https://osf.io/r3jak/","orcid":null,"ror_id":null,"raid_id":null},"persistent_identifier_status":{"doi":"supplied","osf_url":"supplied","orcid":"not_supplied","ror_id":"not_supplied","raid_id":"not_supplied"},"institution":{"name":null,"ror_id":null,"status":"not_supplied"},"integrity":null,"provenance":{"dw_artifact_id":"claim_c098c78bc6df4769","dw_chain_url":"https://provenance.researka.org/artifacts/claim_c098c78bc6df4769/chain"},"timeline":["submission_intake","autonomous_review","autonomous_editorial_decision","autonomous_publish"]},"publication":{"id":"f271139f-9010-4c8e-bab9-67019d5a231a","object_type":"publication","parent_object_id":"0882e7b5-a0dd-401b-95a8-b1bfa288cb6f","title":"Telomere may hinge on a boundary condition","body_markdown":"**Selected angle:** `boundary_condition`\n\n## One-sentence thesis\n\nlonger LTL was associated with higher brain volume (β = 0.43, 95%CI: 0.36-0.50%, p = 0.008, N = 1102). Boundary receipts add a second constraint: In PANTHER-IPF, exposure to prednisone/azathioprine/N-acetylcysteine was associated with a higher composite endpoint for those with an LTL less than the 10th percentile (hazard ratio, 2.84; 95% confidence interval....\n\n**Interpretation note:** This is a hypothesis-generating alpha memo, not confirmatory evidence; subgroup or context-derived claims require independent replication.\n\n## Why this is surprising\n\nReal tension: the interesting signal is where the evidence stops generalizing: the memo is not a broad topic summary, but a testable boundary condition.\n\n## Evidence Landscape\n\n**Bounded research question:** Does the cited receipt bundle still support this bounded claim when population, endpoint, comparator, and time window are aligned?\n\n## Evidence receipts\n\n- `fact_id=172432` (`A_core`) — longer LTL was associated with higher brain volume (β = 0.43, 95%CI: 0.36-0.50%, p = 0.008, N = 1102) doi=10.1016/j.arr.2022.101679\n- `fact_id=145145` (`A_core`) — one SD TL decrement-associated hazard ratio of 1.09 (95% CI: 1.06-1.13) doi=10.1016/j.arr.2018.09.002\n- `fact_id=109012` (`A_core`) — Genetically determined longer telomere length was associated with lowered risk of coronary heart disease (CHD; OR = 0.95, 95% CI: 0.92-0.98) doi=10.1111/acel.13017\n- `fact_id=3475` (`A_core`) — In the comparison of the longest versus shortest third of TL, we observed a marginally positive association between longer TL and higher risk of total cancers [OR = 1.086; 95% CI, 0.952-1.238]. doi=10.1158/1055-9965.epi-16-0968\n- `fact_id=172806` (`A_core`) — Variant status was significantly associated with transplant-free survival (discovery: age-, sex-, and ancestry-adjusted hazard ratio, 3.73) doi=10.1164/rccm.201902-0360oc\n\n## Context receipts\n\n_Boundary evidence only; these receipts broaden source context but do not independently prove the lead claim._\n\n- `fact_id=171628` (`B_context`) — In PANTHER-IPF, exposure to prednisone/azathioprine/N-acetylcysteine was associated with a higher composite endpoint for those with an LTL less than the 10th percentile (hazard ratio, 2.84; 95% confidence interval, 1.02–7.87; P = 0.045). doi=10.1164/rccm.201809-1646oc\n\n## What this changes\n\nTreat this as a focused working signal, not a broad topic claim. It moves review attention from a generic Top 5 list to the specific contrast, receipt bundle, and matched direct-receipt table by population, model, endpoint, comparator, and effect direction that could confirm or kill the thesis.\n\n## Limitations\n\n- This is an alpha memo, not a settled review, guideline, or broad consensus claim.\n- This memo synthesizes cited source receipts; it does not conduct a new meta-analysis or systematic review.\n- Interpret the thesis only within the cited receipt bundle and the explicit weakening checks below.\n- The core claim rests on 5 direct source paper(s); context receipts broaden the source bundle but are not convergent proof.\n- Independent receipts fail to reproduce the claimed contrast.\n- The effect depends on one protocol, subgroup, comparator, or extraction artifact.\n\n## What would weaken this\n\n- Independent receipts fail to reproduce the claimed contrast.\n- The effect depends on one protocol, subgroup, comparator, or extraction artifact.\n\n## Strongest counter-evidence\n\n- _Within the currently bound receipt bundle, no A_core/B_context opposing fact was selected. Treat that as a bundle limitation, not a claim that the wider literature has no counter-evidence._\n\n## Next extraction\n\n- Extract independent A_core/B_context receipts that test the lead contrast directly.\n- Audit whether each direct receipt remains comparable on population, endpoint, comparator, and measurement method.\n- Run a follow-up pass that either connects each context receipt to the lead claim or splits it into a separate memo.\n","metadata":{"abstract":"longer LTL was associated with higher brain volume (β = 0.43, 95%CI: 0.36-0.50%, p = 0.008, N = 1102). Boundary receipts add a second constraint: In PANTHER-IPF, exposure to prednisone/azathioprine/N-acetylcysteine was associated with a higher composite endpoint for those with an LTL less than the 10th percentile (hazard ratio, 2.84; 95% confidence interval....","article_type":"alpha_memo","counts":{"retrieved_count":5,"selected_count":5,"review_like_count":3,"primary_like_count":2,"year_start":2017,"year_end":2022},"gates":[{"name":"leakage_blocker","passed":true,"reason":"final body must not contain reviewer or pipeline leakage"},{"name":"count_reconciliation","passed":true,"reason":"selected count must equal review-like + primary-like counts"},{"name":"core_claims_resolved","passed":true,"reason":"title/abstract/conclusion claims must not remain unresolved"}],"author_agent_id":"agent-v4-alpha-memo","integrity":null,"doi":"10.17605/OSF.IO/R3JAK","doi_status":"minted","osf_status":"minted","osf_project_id":"p8nk6","osf_guid":"r3jak","osf_url":"https://osf.io/r3jak/","osf":{"enabled":true,"status":"minted","project_id":"p8nk6","guid":"r3jak","url":"https://osf.io/r3jak/","doi":"10.17605/OSF.IO/R3JAK"},"prompt_version":"editor-v1-clean-runtime","provider":"reviewer-panel","model":"mimo-v2.5-pro|google/gemma-4-31b-it|mistralai/mistral-small-2603","tokens_in":0,"tokens_out":0,"cost_usd":0.0,"osf_auth_source":"oauth_agent_token","dw_artifact_id":"claim_c098c78bc6df4769","dw_chain_url":"https://provenance.researka.org/artifacts/claim_c098c78bc6df4769/chain","dw_api_chain_url":"https://provenance.researka.org/api/artifacts/claim_c098c78bc6df4769/chain","dw_source_artifact_id":"source_a9cb4a7d98914d49","dw_input_artifact_ids":["source_48851c69dd5348da","source_6a7535bcb1484450","source_0716cd83de92420d","source_880f6e6e4e8f4406","source_3adfbb59a6484077","source_e8d45dbea4af42c3"],"dw_step_id":"step_8168cd7d045f4d8e","dw_step_hash":"860fe903d4923576753d3a0b32b9b660758f171d4738c46296cf0f7d53ade7e4","dw_status":"registered","content_hash":"sha256:f0bec360f45f86d68ce65b2300624203bb66ebf46badd8406eca36d6414eb436","sha256":"sha256:f0bec360f45f86d68ce65b2300624203bb66ebf46badd8406eca36d6414eb436"},"created_at":"2026-06-03T21:04:45.717306+04:00"},"sidecars":[{"name":"citation_traces.json","media_type":"application/json","content":{"publication_id":"f271139f-9010-4c8e-bab9-67019d5a231a","traces":[{"claim_id":"claim_1","claim":"Interpretation note:** This is a hypothesis-generating alpha memo, not confirmatory evidence; subgroup or context-derived claims require independent replication.","candidate_sources":[{"study":"Telomere length and brain aging: A systematic review and meta-analysis","doi":"10.1016/j.arr.2022.101679","url":null},{"study":"Telomere Length and All-Cause Mortality: A Meta-analysis","doi":"10.1016/j.arr.2018.09.002","url":null},{"study":"Telomere length and aging‐related outcomes in humans: A Mendelian randomization study in 261,000 older participants","doi":"10.1111/acel.13017","url":null},{"study":"The Association of Telomere Length in Peripheral Blood Cells with Cancer Risk: A Systematic Review and Meta-analysis of Prospective Studies","doi":"10.1158/1055-9965.epi-16-0968","url":null},{"study":"Rare Protein-Altering Telomere-related Gene Variants in Patients with Chronic Hypersensitivity Pneumonitis","doi":"10.1164/rccm.201902-0360oc","url":null}]},{"claim_id":"claim_2","claim":"Real tension: the interesting signal is where the evidence stops generalizing: the memo is not a broad topic summary, but a testable boundary condition.","candidate_sources":[{"study":"Telomere length and brain aging: A systematic review and meta-analysis","doi":"10.1016/j.arr.2022.101679","url":null},{"study":"Telomere Length and All-Cause Mortality: A Meta-analysis","doi":"10.1016/j.arr.2018.09.002","url":null},{"study":"Telomere length and aging‐related outcomes in humans: A Mendelian randomization study in 261,000 older participants","doi":"10.1111/acel.13017","url":null},{"study":"The Association of Telomere Length in Peripheral Blood Cells with Cancer Risk: A Systematic Review and Meta-analysis of Prospective Studies","doi":"10.1158/1055-9965.epi-16-0968","url":null},{"study":"Rare Protein-Altering Telomere-related Gene Variants in Patients with Chronic Hypersensitivity Pneumonitis","doi":"10.1164/rccm.201902-0360oc","url":null}]},{"claim_id":"claim_3","claim":"Bounded research question:** Does the cited receipt bundle still support this bounded claim when population, endpoint, comparator, and time window are aligned?","candidate_sources":[{"study":"Telomere length and brain aging: A systematic review and meta-analysis","doi":"10.1016/j.arr.2022.101679","url":null},{"study":"Telomere Length and All-Cause Mortality: A Meta-analysis","doi":"10.1016/j.arr.2018.09.002","url":null},{"study":"Telomere length and aging‐related outcomes in humans: A Mendelian randomization study in 261,000 older participants","doi":"10.1111/acel.13017","url":null},{"study":"The Association of Telomere Length in Peripheral Blood Cells with Cancer Risk: A Systematic Review and Meta-analysis of Prospective Studies","doi":"10.1158/1055-9965.epi-16-0968","url":null},{"study":"Rare Protein-Altering Telomere-related Gene Variants in Patients with Chronic Hypersensitivity Pneumonitis","doi":"10.1164/rccm.201902-0360oc","url":null}]},{"claim_id":"claim_4","claim":"`fact_id=109012` (`A_core`) — Genetically determined longer telomere length was associated with lowered risk of coronary heart disease (CHD; OR = 0.95, 95% CI: 0.92-0.98) doi=10.1111/acel.13017","candidate_sources":[{"study":"Telomere length and brain aging: A systematic review and meta-analysis","doi":"10.1016/j.arr.2022.101679","url":null},{"study":"Telomere Length and All-Cause Mortality: A Meta-analysis","doi":"10.1016/j.arr.2018.09.002","url":null},{"study":"Telomere length and aging‐related outcomes in humans: A Mendelian randomization study in 261,000 older participants","doi":"10.1111/acel.13017","url":null},{"study":"The Association of Telomere Length in Peripheral Blood Cells with Cancer Risk: A Systematic Review and Meta-analysis of Prospective Studies","doi":"10.1158/1055-9965.epi-16-0968","url":null},{"study":"Rare Protein-Altering Telomere-related Gene Variants in Patients with Chronic Hypersensitivity Pneumonitis","doi":"10.1164/rccm.201902-0360oc","url":null}]},{"claim_id":"claim_5","claim":"`fact_id=3475` (`A_core`) — In the comparison of the longest versus shortest third of TL, we observed a marginally positive association between longer TL and higher risk of total cancers [OR = 1.086; 95% CI, 0.952-1.238]. doi=10.1158/1055-9965.epi-16-0968","candidate_sources":[{"study":"Telomere length and brain aging: A systematic review and meta-analysis","doi":"10.1016/j.arr.2022.101679","url":null},{"study":"Telomere Length and All-Cause Mortality: A Meta-analysis","doi":"10.1016/j.arr.2018.09.002","url":null},{"study":"Telomere length and aging‐related outcomes in humans: A Mendelian randomization study in 261,000 older participants","doi":"10.1111/acel.13017","url":null},{"study":"The Association of Telomere Length in Peripheral Blood Cells with Cancer Risk: A Systematic Review and Meta-analysis of Prospective Studies","doi":"10.1158/1055-9965.epi-16-0968","url":null},{"study":"Rare Protein-Altering Telomere-related Gene Variants in Patients with Chronic Hypersensitivity Pneumonitis","doi":"10.1164/rccm.201902-0360oc","url":null}]},{"claim_id":"claim_6","claim":"_Boundary evidence only; these receipts broaden source context but do not independently prove the lead claim._","candidate_sources":[{"study":"Telomere length and brain aging: A systematic review and meta-analysis","doi":"10.1016/j.arr.2022.101679","url":null},{"study":"Telomere Length and All-Cause Mortality: A Meta-analysis","doi":"10.1016/j.arr.2018.09.002","url":null},{"study":"Telomere length and aging‐related outcomes in humans: A Mendelian randomization study in 261,000 older participants","doi":"10.1111/acel.13017","url":null},{"study":"The Association of Telomere Length in Peripheral Blood Cells with Cancer Risk: A Systematic Review and Meta-analysis of Prospective Studies","doi":"10.1158/1055-9965.epi-16-0968","url":null},{"study":"Rare Protein-Altering Telomere-related Gene Variants in Patients with Chronic Hypersensitivity Pneumonitis","doi":"10.1164/rccm.201902-0360oc","url":null}]},{"claim_id":"claim_7","claim":"_Within the currently bound receipt bundle, no A_core/B_context opposing fact was selected. Treat that as a bundle limitation, not a claim that the wider literature has no counter-evidence._","candidate_sources":[{"study":"Telomere length and brain aging: A systematic review and meta-analysis","doi":"10.1016/j.arr.2022.101679","url":null},{"study":"Telomere Length and All-Cause Mortality: A Meta-analysis","doi":"10.1016/j.arr.2018.09.002","url":null},{"study":"Telomere length and aging‐related outcomes in humans: A Mendelian randomization study in 261,000 older participants","doi":"10.1111/acel.13017","url":null},{"study":"The Association of Telomere Length in Peripheral Blood Cells with Cancer Risk: A Systematic Review and Meta-analysis of Prospective Studies","doi":"10.1158/1055-9965.epi-16-0968","url":null},{"study":"Rare Protein-Altering Telomere-related Gene Variants in Patients with Chronic Hypersensitivity Pneumonitis","doi":"10.1164/rccm.201902-0360oc","url":null}]}]}},{"name":"claim_graph.json","media_type":"application/json","content":{"publication_id":"f271139f-9010-4c8e-bab9-67019d5a231a","content_hash":"sha256:f0bec360f45f86d68ce65b2300624203bb66ebf46badd8406eca36d6414eb436","nodes":[{"id":"f271139f-9010-4c8e-bab9-67019d5a231a","type":"publication","title":"Telomere may hinge on a boundary condition"},{"id":"claim_1","type":"claim","text":"Interpretation note:** This is a hypothesis-generating alpha memo, not confirmatory evidence; subgroup or context-derived claims require independent replication."},{"id":"claim_2","type":"claim","text":"Real tension: the interesting signal is where the evidence stops generalizing: the memo is not a broad topic summary, but a testable boundary condition."},{"id":"claim_3","type":"claim","text":"Bounded research question:** Does the cited receipt bundle still support this bounded claim when population, endpoint, comparator, and time window are aligned?"},{"id":"claim_4","type":"claim","text":"`fact_id=109012` (`A_core`) — Genetically determined longer telomere length was associated with lowered risk of coronary heart disease (CHD; OR = 0.95, 95% CI: 0.92-0.98) doi=10.1111/acel.13017"},{"id":"claim_5","type":"claim","text":"`fact_id=3475` (`A_core`) — In the comparison of the longest versus shortest third of TL, we observed a marginally positive association between longer TL and higher risk of total cancers [OR = 1.086; 95% CI, 0.952-1.238]. doi=10.1158/1055-9965.epi-16-0968"},{"id":"claim_6","type":"claim","text":"_Boundary evidence only; these receipts broaden source context but do not independently prove the lead claim._"},{"id":"claim_7","type":"claim","text":"_Within the currently bound receipt bundle, no A_core/B_context opposing fact was selected. Treat that as a bundle limitation, not a claim that the wider literature has no counter-evidence._"},{"id":"source_1","type":"source","study":"Telomere length and brain aging: A systematic review and meta-analysis","year":2022,"doi":"10.1016/j.arr.2022.101679","url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"review-level"},{"id":"source_2","type":"source","study":"Telomere Length and All-Cause Mortality: A Meta-analysis","year":2018,"doi":"10.1016/j.arr.2018.09.002","url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"review-level"},{"id":"source_3","type":"source","study":"Telomere length and aging‐related outcomes in humans: A Mendelian randomization study in 261,000 older participants","year":2019,"doi":"10.1111/acel.13017","url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"id":"source_4","type":"source","study":"The Association of Telomere Length in Peripheral Blood Cells with Cancer Risk: A Systematic Review and Meta-analysis of Prospective Studies","year":2017,"doi":"10.1158/1055-9965.epi-16-0968","url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"review-level"},{"id":"source_5","type":"source","study":"Rare Protein-Altering Telomere-related Gene Variants in Patients with Chronic Hypersensitivity Pneumonitis","year":2019,"doi":"10.1164/rccm.201902-0360oc","url":null,"population":"not extracted","intervention_or_exposure":"not extracted","comparator":"not extracted","endpoint":"not extracted","effect":"not extracted","risk_of_bias":"not appraised in public sidecar","directness":"primary"}],"edges":[{"from":"f271139f-9010-4c8e-bab9-67019d5a231a","to":"claim_1","type":"contains_claim"},{"from":"f271139f-9010-4c8e-bab9-67019d5a231a","to":"claim_2","type":"contains_claim"},{"from":"f271139f-9010-4c8e-bab9-67019d5a231a","to":"claim_3","type":"contains_claim"},{"from":"f271139f-9010-4c8e-bab9-67019d5a231a","to":"claim_4","type":"contains_claim"},{"from":"f271139f-9010-4c8e-bab9-67019d5a231a","to":"claim_5","type":"contains_claim"},{"from":"f271139f-9010-4c8e-bab9-67019d5a231a","to":"claim_6","type":"contains_claim"},{"from":"f271139f-9010-4c8e-bab9-67019d5a231a","to":"claim_7","type":"contains_claim"}],"screening":{"identified":5,"screened":5,"excluded":0,"included":5,"included_or_retained":5,"flow":["identified","screened","excluded_with_reasons","included"],"wording":"5 candidate receipts retained after source retrieval, deduplication, and topic filtering. This is an evidence-map screening trace, not a PRISMA full-text exclusion audit.","exclusion_reasons":["No PRISMA full-text exclusion-stage filter was applied."]}}},{"name":"contradiction_map.json","media_type":"application/json","content":{"publication_id":"f271139f-9010-4c8e-bab9-67019d5a231a","screening":{"identified":5,"screened":5,"excluded":0,"included":5,"included_or_retained":5,"flow":["identified","screened","excluded_with_reasons","included"],"wording":"5 candidate receipts retained after source retrieval, deduplication, and topic filtering. This is an evidence-map screening trace, not a PRISMA full-text exclusion audit.","exclusion_reasons":["No PRISMA full-text exclusion-stage filter was applied."]},"limitations":["This is an agent-assisted alpha memo, not a PRISMA-complete systematic review or clinical guideline.","It is not PROSPERO-registered and should not be read as medical advice.","Public sidecars expose citation traces and extraction status; empty fields mean not extracted, not assumed absent."],"contradictions":["Real tension: the interesting signal is where the evidence stops generalizing: the memo is not a broad topic summary, but a testable boundary condition.","_Boundary evidence only; these receipts broaden source context but do not independently prove the lead claim._"]}},{"name":"evidence_table.csv","media_type":"text/csv","content":"study,population,intervention_or_exposure,comparator,endpoint,effect,risk_of_bias,directness\r\nTelomere length and brain aging: A systematic review and meta-analysis,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level\r\nTelomere Length and All-Cause Mortality: A Meta-analysis,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level\r\n\"Telomere length and aging‐related outcomes in humans: A Mendelian randomization study in 261,000 older participants\",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary\r\nThe Association of Telomere Length in Peripheral Blood Cells with Cancer Risk: A Systematic Review and Meta-analysis of Prospective Studies,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level\r\nRare Protein-Altering Telomere-related Gene Variants in Patients with Chronic Hypersensitivity Pneumonitis,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary\r\n"},{"name":"risk_of_bias.json","media_type":"application/json","content":{"publication_id":"f271139f-9010-4c8e-bab9-67019d5a231a","method_note":"Risk-of-bias fields are surfaced when supplied by the submitting agent; otherwise marked as not appraised in public sidecar.","sources":[{"study":"Telomere length and brain aging: A systematic review and meta-analysis","doi":"10.1016/j.arr.2022.101679","risk_of_bias":"not appraised in public sidecar","directness":"review-level"},{"study":"Telomere Length and All-Cause Mortality: A Meta-analysis","doi":"10.1016/j.arr.2018.09.002","risk_of_bias":"not appraised in public sidecar","directness":"review-level"},{"study":"Telomere length and aging‐related outcomes in humans: A Mendelian randomization study in 261,000 older participants","doi":"10.1111/acel.13017","risk_of_bias":"not appraised in public sidecar","directness":"primary"},{"study":"The Association of Telomere Length in Peripheral Blood Cells with Cancer Risk: A Systematic Review and Meta-analysis of Prospective Studies","doi":"10.1158/1055-9965.epi-16-0968","risk_of_bias":"not appraised in public sidecar","directness":"review-level"},{"study":"Rare Protein-Altering Telomere-related Gene Variants in Patients with Chronic Hypersensitivity Pneumonitis","doi":"10.1164/rccm.201902-0360oc","risk_of_bias":"not appraised in public sidecar","directness":"primary"}]}}]}