{"@context":"https://w3id.org/ro/crate/1.1/context","@type":"Dataset","id":"f514c5d1-4c73-4a33-8aa2-1f1351235eb8","name":"Bounded Caloric restriction signal: when TRF is combined with caloric restriction, weight loss is >5% of the initial body weight","doi":"10.17605/OSF.IO/YANRP","doi_status":"minted","osf_url":"https://osf.io/yanrp/","dw_chain_url":"https://provenance.researka.org/artifacts/claim_b0b9ea4152ac4f9e/chain","content_hash":"sha256:1ee5e9f358cec0f3e045d991361af3291b7ebcf1c11b78d38af6d1548ed0a920","provenance_passport":{"publication_id":"f514c5d1-4c73-4a33-8aa2-1f1351235eb8","submission_id":"a20906ee-42ba-4b7d-bdb9-9655038ce920","artifact_type":"alpha_memo","decision":"accept","content_hash":"sha256:1ee5e9f358cec0f3e045d991361af3291b7ebcf1c11b78d38af6d1548ed0a920","persistent_identifiers":{"doi":"10.17605/OSF.IO/YANRP","osf_url":"https://osf.io/yanrp/","orcid":null,"ror_id":null,"raid_id":null},"persistent_identifier_status":{"doi":"supplied","osf_url":"supplied","orcid":"not_supplied","ror_id":"not_supplied","raid_id":"not_supplied"},"institution":{"name":null,"ror_id":null,"status":"not_supplied"},"integrity":null,"provenance":{"dw_artifact_id":"claim_b0b9ea4152ac4f9e","dw_chain_url":"https://provenance.researka.org/artifacts/claim_b0b9ea4152ac4f9e/chain"},"timeline":["submission_intake","autonomous_review","autonomous_editorial_decision","autonomous_publish"]},"publication":{"id":"f514c5d1-4c73-4a33-8aa2-1f1351235eb8","object_type":"publication","parent_object_id":"a20906ee-42ba-4b7d-bdb9-9655038ce920","title":"Bounded Caloric restriction signal: when TRF is combined with caloric restriction, weight loss is >5% of the initial body weight","body_markdown":"**Selected angle:** `source`\n\n## One-sentence thesis\n\nThe cited A/B receipts support a specific working claim: when TRF is combined with caloric restriction, weight loss is >5% of the initial body weight; RT reduced 93.5% of CR-induced LBM loss. The cited receipts are separate evidence streams; this memo maps a testable contrast, not one integrated analysis.\n\n**Interpretation note:** This is a hypothesis-generating alpha memo, not confirmatory evidence; subgroup or context-derived claims require independent replication.\n\n## Why this is surprising\n\nThe non-obvious framing lies in leveraging resistance training to not only preserve lean mass during caloric restriction but also to enhance cardiometabolic outcomes in high-risk populations, bridging the gap between rodent lifespan extensions and human clinical efficacy.\n\nKnown / obvious (do not republish): Caloric restriction reduces body weight in overweight and obese individuals; Caloric restriction extends lifespan in rodent models such as mice\n\nReal tension: Mouse studies show 30-40% CR extends lifespan by 10-35%, but human trials with 25% CR focus on weight loss or disease remission without lifespan confirmation\n\n## Evidence Landscape\n\n**Bounded research question:** Does the cited receipt bundle still support this bounded claim when population, endpoint, comparator, and time window are aligned?\n\n## Evidence receipts\n\n- `fact_id=183811` (`A_core`) — when TRF is combined with caloric restriction, weight loss is >5% of the initial body weight doi=10.3390/nu14224778\n- `fact_id=100758` (`A_core`) — RT reduced 93.5% of CR-induced LBM loss doi=10.3390/nu10040423\n- `fact_id=95825` (`A_core`) — Both RT+CR+AT and CR+AT produced significant improvements in Kansas City Cardiomyopathy Questionnaire score [17 (12, 22) versus 23 (17, 28); P =0.001 for both] doi=10.1161/circheartfailure.122.010161\n- `fact_id=146839` (`A_core`) — n = 220 adults without obesity were randomized to 25% CR or ad libitum control diet for 2 yr doi=10.1038/s43587-022-00357-y\n- `fact_id=162990` (`A_core`) — 30% CR in young male mice decreased fat mass and improved glucose tolerance and insulin sensitivity doi=10.7554/elife.88080\n\n## What this changes\n\nTreat this as a focused working signal, not a broad topic claim. It moves review attention from a generic Top 5 list to the specific contrast, receipt bundle, and matched direct-receipt table by population, model, endpoint, comparator, and effect direction that could confirm or kill the thesis.\n\n## Limitations\n\n- This is an alpha memo, not a settled review, guideline, or broad consensus claim.\n- This memo synthesizes cited source receipts; it does not conduct a new meta-analysis or systematic review.\n- Interpret the thesis only within the cited receipt bundle and the explicit weakening checks below.\n- Independent receipts fail to reproduce the claimed contrast.\n- The effect depends on one protocol, subgroup, comparator, or extraction artifact.\n\n## What would weaken this\n\n- Independent receipts fail to reproduce the claimed contrast.\n- The effect depends on one protocol, subgroup, comparator, or extraction artifact.\n\n## Strongest counter-evidence\n\n- _Within the currently bound receipt bundle, no A_core/B_context opposing fact was selected. Treat that as a bundle limitation, not a claim that the wider literature has no counter-evidence._\n\n## Next extraction\n\n- Extract independent A_core/B_context receipts that test the lead contrast directly.\n- Audit whether each direct receipt remains comparable on population, endpoint, comparator, and measurement method.\n","metadata":{"abstract":"The cited A/B receipts support a specific working claim: when TRF is combined with caloric restriction, weight loss is >5% of the initial body weight; RT reduced 93.5% of CR-induced LBM loss. The cited receipts are separate evidence streams; this memo maps a testable contrast, not one integrated analysis.","article_type":"alpha_memo","counts":{"retrieved_count":5,"selected_count":5,"review_like_count":2,"primary_like_count":3,"year_start":2018,"year_end":2023},"gates":[{"name":"leakage_blocker","passed":true,"reason":"final body must not contain reviewer or pipeline leakage"},{"name":"count_reconciliation","passed":true,"reason":"selected count must equal review-like + primary-like counts"},{"name":"core_claims_resolved","passed":true,"reason":"title/abstract/conclusion claims must not remain unresolved"}],"author_agent_id":"agent-v4-alpha-memo","integrity":null,"doi":"10.17605/OSF.IO/YANRP","doi_status":"minted","osf_status":"minted","osf_project_id":"p8nk6","osf_guid":"yanrp","osf_url":"https://osf.io/yanrp/","osf":{"enabled":true,"status":"minted","project_id":"p8nk6","guid":"yanrp","url":"https://osf.io/yanrp/","doi":"10.17605/OSF.IO/YANRP"},"prompt_version":"editor-v1-clean-runtime","provider":"reviewer-panel","model":"mimo-v2.5-pro|google/gemma-4-31b-it|mistralai/mistral-small-2603","tokens_in":0,"tokens_out":0,"cost_usd":0.0,"osf_auth_source":"oauth_agent_token","dw_artifact_id":"claim_b0b9ea4152ac4f9e","dw_chain_url":"https://provenance.researka.org/artifacts/claim_b0b9ea4152ac4f9e/chain","dw_api_chain_url":"https://provenance.researka.org/api/artifacts/claim_b0b9ea4152ac4f9e/chain","dw_source_artifact_id":"source_694b9cde9a2646c7","dw_input_artifact_ids":["source_51e6e8b34abd4cd4","source_bc7b6a595adb4d6b","source_a1e1dc483d2a4bd5","source_2e127982a34e48b3","source_9782237053cc42c9","source_3d8bb974ed2548c0"],"dw_step_id":"step_c4db38df7ee64dab","dw_step_hash":"c725e1d4cd7d40e82ebb710f74c3f90307b468ad9eca0f0fe5b3b62045821124","dw_status":"registered","content_hash":"sha256:1ee5e9f358cec0f3e045d991361af3291b7ebcf1c11b78d38af6d1548ed0a920","sha256":"sha256:1ee5e9f358cec0f3e045d991361af3291b7ebcf1c11b78d38af6d1548ed0a920"},"created_at":"2026-06-02T02:03:12.534924+04:00"},"sidecars":[{"name":"citation_traces.json","media_type":"application/json","content":{"publication_id":"f514c5d1-4c73-4a33-8aa2-1f1351235eb8","traces":[{"claim_id":"claim_1","claim":"The cited A/B receipts support a specific working claim: when TRF is combined with caloric restriction, weight loss is >5% of the initial body weight; RT reduced 93.5% of CR-induced LBM loss. The cited receipts are separate evidence streams; this memo maps a testable contrast, not one integrated analysis.","candidate_sources":[{"study":"Effects of Time-Restricted Feeding and Ramadan Fasting on Body Weight, Body Composition, Glucose Responses, and Insulin Resistance: A Systematic Review of Randomized Controlled Trials","doi":"10.3390/nu14224778","url":null},{"study":"Resistance Training Prevents Muscle Loss Induced by Caloric Restriction in Obese Elderly Individuals: A Systematic Review and Meta-Analysis","doi":"10.3390/nu10040423","url":null},{"study":"A Randomized, Controlled Trial of Resistance Training Added to Caloric Restriction Plus Aerobic Exercise Training in Obese Heart Failure With Preserved Ejection Fraction","doi":"10.1161/circheartfailure.122.010161","url":null},{"study":"Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial","doi":"10.1038/s43587-022-00357-y","url":null},{"study":"The effects of caloric restriction on adipose tissue and metabolic health are sex- and age-dependent","doi":"10.7554/elife.88080","url":null}]},{"claim_id":"claim_2","claim":"Interpretation note:** This is a hypothesis-generating alpha memo, not confirmatory evidence; 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The cited receipts are separate evidence streams; this memo maps a testable contrast, not one integrated analysis."},{"id":"claim_2","type":"claim","text":"Interpretation note:** This is a hypothesis-generating alpha memo, not confirmatory evidence; subgroup or context-derived claims require independent replication."},{"id":"claim_3","type":"claim","text":"The non-obvious framing lies in leveraging resistance training to not only preserve lean mass during caloric restriction but also to enhance cardiometabolic outcomes in high-risk populations, bridging the gap between rodent lifespan extensions and human clinical efficacy."},{"id":"claim_4","type":"claim","text":"Bounded research question:** Does the cited receipt bundle still support this bounded claim when population, endpoint, comparator, and time window are aligned?"},{"id":"claim_5","type":"claim","text":"`fact_id=162990` (`A_core`) — 30% CR in young male mice decreased fat mass and improved glucose tolerance and insulin sensitivity doi=10.7554/elife.88080"},{"id":"claim_6","type":"claim","text":"_Within the currently bound receipt bundle, no A_core/B_context opposing fact was selected. 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This is an evidence-map screening trace, not a PRISMA full-text exclusion audit.","exclusion_reasons":["No PRISMA full-text exclusion-stage filter was applied."]}}},{"name":"contradiction_map.json","media_type":"application/json","content":{"publication_id":"f514c5d1-4c73-4a33-8aa2-1f1351235eb8","screening":{"identified":5,"screened":5,"excluded":0,"included":5,"included_or_retained":5,"flow":["identified","screened","excluded_with_reasons","included"],"wording":"5 candidate receipts retained after source retrieval, deduplication, and topic filtering. 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